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Development of a hybrid scaffold and a bioreactor for cartilage regeneration

  • Articles/Bionic Engineering
  • Published:
Chinese Science Bulletin

Abstract

We developed a hybrid scaffold and a bioreactor for cartilage regeneration. The hybrid scaffold was developed as combination of two components: a biodegradable framework and hydrogel-containing chondrocytes. We performed the MTT cell proliferation assay to compare the proliferation and viability of chondrocytes on three types of scaffolds: an alginate gel, the hybrid scaffold, and an alginate sponge. Cells were encapsulated in 2% agarose gel. The bioreactor consisted of a circulation system and a compression system. We performed dynamic cell culture on these agarose gels in the bioreactor for 3 days.

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Author information

Authors and Affiliations

  1. BK21 Mechatronics Group at Chungnam National University, Daejeon, 305-764, Korea

    Seung-Jae Lee

  2. School of Mechanical Engineering, Chungbuk National University, Cheongju, 361-763, Korea

    In Hwan Lee & Jeong Hun Park

  3. DDS Research Lab., CKD Research Institute, CKD Pharmaceutical Corp., Cheonan, 330-831, Korea

    So-Jung Gwak

  4. Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Korea

    Jong-Won Rhie

  5. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 790-784, Korea

    Dong-Woo Cho

  6. School of Mechanical Engineering, Yeungnam University, Gyeungsan, 712-749, Korea

    Tae Jo Ko

  7. School of Mechanical Engineering, Chung-Ang University, Seoul, 156-756, Korea

    Dong Sung Kim

Authors
  1. Seung-Jae Lee
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  2. In Hwan Lee
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  3. Jeong Hun Park
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  4. So-Jung Gwak
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  5. Jong-Won Rhie
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  6. Dong-Woo Cho
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  7. Tae Jo Ko
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  8. Dong Sung Kim
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Corresponding author

Correspondence to In Hwan Lee.

Additional information

Supported by the Korea Science and Engineering Foundation (Grant No. R01-2008-000-20568-0), Center for Nanoscale Mechatronics & Manufacturing, and 21st Century Frontier Research Programs of Ministry of Education, Science and Technology, Korea.

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Lee, SJ., Lee, I.H., Park, J.H. et al. Development of a hybrid scaffold and a bioreactor for cartilage regeneration. Chin. Sci. Bull. 54, 3608–3612 (2009). https://doi.org/10.1007/s11434-009-0602-8

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  • DOI: https://doi.org/10.1007/s11434-009-0602-8

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