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Comparative study of microstructural remodification to porous β-TCP and HA in rabbits

  • Special Topic/Articles/Biomedical Materials
  • Published:
Chinese Science Bulletin

Abstract

To assess the remolding ability of repaired bone in hydroxyapatite (HA) and β-calcium phosphate (β-TCP) scaffold, two 75% porosity bioceramics with the same three-dimensional geometry were implanted into femoral condyles of rabbits. Histological and micro-computed tomography (micro-CT) results demonstrated abundant new bone formation in the porous HA scaffold along with indistinctive scaffold degradation. Results also indicated that scaffold resorption in the β-TCP group, which was followed by a replacement with newly formed bone, was significantly higher than that in the HA group. The crosslinking trabeculae remodeled from the mixtures of the newly formed bone and β-TCP scaffold remnants might be helpful to promoting even loading and reducing stress. The bone remodeling pattern resulted from bone formation and scaffold resorption was significantly different for the two bioceramics. The results demonstrated that the 75% porous β-TCP was more suitable for new bone remodification than HA scaffold.

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Authors and Affiliations

  1. Ninth People’s Hospital, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Biomaterials Research & Test Center, Shanghai Jiaotong University, Shanghai, 200023, China

    Jiao Sun, QingYi Shen & JianXi Lu

Authors
  1. Jiao Sun
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  2. QingYi Shen
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  3. JianXi Lu
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Corresponding author

Correspondence to Jiao Sun.

Additional information

Supported by the Shanghai Sci-Tech Committee Foundation (Grant No. 08DZ2291600) and Shanghai Leading Academic Discipline Project (Grant No. S30206)

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Sun, J., Shen, Q. & Lu, J. Comparative study of microstructural remodification to porous β-TCP and HA in rabbits. Chin. Sci. Bull. 54, 2962–2967 (2009). https://doi.org/10.1007/s11434-009-0332-y

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  • DOI: https://doi.org/10.1007/s11434-009-0332-y

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