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Fabrication and characterization of 3D scaffold using 3D plotting system

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  • Bionic Engineering
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Chinese Science Bulletin

Abstract

In this paper, we design and fabricate a 3D scaffold using rapid prototyping (RP) technology for tissue engineering. The scaffold should have a three-dimensional interconnected pore network. We fabricate a polycaprolactone (PCL) scaffold with interconnecting pores and uniform porosity for cell ingrowth using a 3D plotting system. In order to keep the three dimensional shape under mechanical loading while implanted, we design an oscillating nozzle system to increase elastic modulus and yield strength of PCL strand. We characterize the influence of pore geometry, compressive modulus of the scaffold, elastic modulus and yield strength of the strand using SEM, dynamical mechanical analysis (DMA) and Nano-UTM. Finally the cell responses on scaffolds are observed.

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Correspondence to Jun-Hee Lee.

Additional information

We would like to thank Mr. JoonGon Son for his assistance with the experiments. This work was supported by the Basic Research Program of the Korea Institute of Machinery & Materials (KIMM) of Korea (Grant No. 1350013267).

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Lee, JH., Park, SA., Park, K. et al. Fabrication and characterization of 3D scaffold using 3D plotting system. Chin. Sci. Bull. 55, 94–98 (2010). https://doi.org/10.1007/s11434-009-0271-7

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  • DOI: https://doi.org/10.1007/s11434-009-0271-7

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