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Methoxy poly(ethylene glycol)-b-poly(ethyl cyanoacrylate) copolymer nanoparticles as delivery vehicles for dexamethasone

  • Special Topic/Articles/Biomedical Materials
  • Published:
Chinese Science Bulletin

Abstract

Methoxy poly(ethylene oxide)-b-poly(ethyl cyanoacrylate) (mPEG-b-PECA), amphiphilic block copolymer, was synthesized via oxyanion-initiated polymerization with a sodium alcoholate-terminated monomethoxy poly(ethylene glycol) as the macroinitiator. mPEG-b-PECA was characterized by GPC, 1H-NMR and FTIR. The results indicate that the structure of mPEG-b-PECA is well controlled with narrow molecular weight distribution. The dexamethasone (DXM)-loaded mPEG-b-PECA nanoparticles (NPs) were prepared by the nanoprecipitation technique and characterized by LPSA, 1H-NMR and TEM. The DXM-loaded mPEG-b-PECA NPs are of spherical shape with the size of less than 100 nm. The drug-loaded amount (DL) and encapsulation efficiency (EE) of DXM-loaded NPs were investigated by HPLC. The results show that DXM can be effectively incorporated into mPEG-b-PECA NPs, which provides a potential delivery system for DXM and other hydrophobic drugs.

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    YingLei Zhai, LianDong Deng, XiaoNa Lin, Li Xiao, FengMin Jin & AnJie Dong

Authors
  1. YingLei Zhai
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  2. LianDong Deng
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  3. XiaoNa Lin
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  4. Li Xiao
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  5. FengMin Jin
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  6. AnJie Dong
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Corresponding author

Correspondence to AnJie Dong.

Additional information

Supported by the Key Project of Tianjin Municipal Natural Science Foundation (Grant No. 08JCZDJC17200), Tianjin Municipal Natural Science Foundation (Grant No. 08JCYBJC01800), and National Natural Science Foundation of China (Grant No. 30672554)

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Zhai, Y., Deng, L., Lin, X. et al. Methoxy poly(ethylene glycol)-b-poly(ethyl cyanoacrylate) copolymer nanoparticles as delivery vehicles for dexamethasone. Chin. Sci. Bull. 54, 2918–2924 (2009). https://doi.org/10.1007/s11434-009-0246-8

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  • DOI: https://doi.org/10.1007/s11434-009-0246-8

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