Abstract
Avian influenza A viruses could get across the species barrier and be fatal to humans. Highly pathogenic avian influenza H5N1 virus was an example. The mechanism of interspecies transmission is not clear as yet. In this research, the protein sequences of 237 influenza A viruses with different subtypes were transformed into pseudo-signals. The energy features were extracted by the method of wavelet packet decomposition and used for virus classification by the method of hierarchical clustering. The clustering results showed that five patterns existed in avian influenza A viruses, which associated with the phenotype of interspecies transmission, and that avian viruses with patterns C and E could across species barrier and those with patterns A, B and D might not have the abilities. The results could be used to construct an early warning system to predict the transmissibility of avian influenza A viruses to humans.
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Supported by the Special Basic Research Funds of China (Grant No. 2007FY210700), Major Program of National Natural Science Foundation of China (Grant No. 90608020), the National Basic Research Program of China (Grant Nos. 2005CB523007 and 2005CB523004) Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20050487037), the Knowledge Innovation Project of the Chinese Academy of Sciences (Grant No. KSCX2-YW-N-065) and the Sixth Framework Program in European (Grant Nos. SP5B-CT-2006-044161 and SP5B-CT-2006-044405)
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Kou, Z., Lei, F., Wang, S. et al. Molecular patterns of avian influenza A viruses. Chin. Sci. Bull. 53, 2002–2007 (2008). https://doi.org/10.1007/s11434-008-0236-2
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DOI: https://doi.org/10.1007/s11434-008-0236-2