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Inducement of Sechenov inhibition by EtOH and NA in the Bufo toad

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  • Neurobiology
  • Published:
Chinese Science Bulletin

Abstract

Central inhibition, discovered by Sechenov in 1862, suggests that electrically stimulating the forebrain or medulla oblongata in frog generally suppresses reflexes. However, the underlying molecular mechanisms are still unclear. Using ethanol (EtOH), noradrenalin (NA), and other neurotransmitters in thalamic preparations, Sechenov inhibition was stimulated in Bufo toads in this study. The result showed that, similar to Sechenov inhibition, the acute application of EtOH or NA excited the thalamus and prolonged the latency of withdrawal reflex. Our study evidences the involvement of α-adrenoceptors in such central inhibition, and explains the role of acute EtOH application in the induction of reflex inhibition.

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Authors and Affiliations

  1. Department of Biological Sciences and Biotechnology, National State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing, 100084, China

    RuXin Li, YingZi Li, Yin Cao & ZuoPing Xie

  2. Department of Physiology, Weifang Medical University, Weifang, 261042, China

    ShanShan Jia & XiuZhen Cheng

Authors
  1. RuXin Li
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  2. ShanShan Jia
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  3. YingZi Li
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  4. Yin Cao
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  5. XiuZhen Cheng
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  6. ZuoPing Xie
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Corresponding authors

Correspondence to XiuZhen Cheng or ZuoPing Xie.

Additional information

Contributed equally to this work

Supported by the Major State Basic Research Development Program of China (973 Program) (Grant No. 2005CB522503)

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Li, R., Jia, S., Li, Y. et al. Inducement of Sechenov inhibition by EtOH and NA in the Bufo toad. Chin. Sci. Bull. 53, 1193–1196 (2008). https://doi.org/10.1007/s11434-008-0189-5

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  • DOI: https://doi.org/10.1007/s11434-008-0189-5

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