Skip to main content
Log in

Fabrication technology of integrated fiber microfluidic electrophoresis chip

  • Articles
  • Analytical Chemistry
  • Published:
Chinese Science Bulletin

Abstract

The technology of PCB was used to fabricate the chip mould, and the microfluidic electrophoresis chip was fabricated with PDMS material. The fiber integrated on the chip was used as the transmission medium, so the light spot size was near the depth of microchannel. The detection sensitivity was improved, and the optical focusing system was spared. The fabrication process, sealing methods and structure characteristic of PDMS microfluidic electrophoresis chips were discussed. The experiment was achieved by using the fabricated chip to separate FITC fluorescein and FITC-labeled amino acid mixture reagent, and the feasibility of the chip was validated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Chabinyc M L, Chiu D T, McDonald J C, et al. An integrated fluorescence detection system in poly (dimethylsiloxane) for microfluidic applications. Anal Chem, 2001, 73(18): 4491–4498

    Article  Google Scholar 

  2. Camous S, Gouy J-P, Fujita H, et al. Integrated 2-D optical lenses in PDMS layer to improve fluorescence spectroscopy using optical fibers. Sens Proc IEEE, 2002, 1: 187–191

    Article  Google Scholar 

  3. Fu L M, Yang R J, Lin C H, et al. Electrokinetically driven micro flow cytometers with integrated Fiber optics for on-line cell/particle detection. Anal Chem, 2003, 78(17): 4491–4498

    Google Scholar 

  4. Merkel T, Pagel L, Glock H-W. Electric fields in fluidic channels and sensor applications with capacitance. Sensor Actuat A Phys, 2000, 80(1): 1–7

    Article  Google Scholar 

  5. Sanders J C, Breadmore M C, Mitchell P S, et al. A simple PDMS-based electro-fluidic interface for microchip electrophoretic separations. Analyst, 2001, 127(12): 1558–1563

    Article  Google Scholar 

  6. Chabinyc M L, Chiu D T, McDonald J C, et al. An integrated fluorescence detection system in poly(dimethylsiloxane) for microfluidic applications. Anal Chem, 2001, 73(18): 4491–4498

    Article  Google Scholar 

  7. Zhang C X, Manz A. Narrow sample channel injectors for capillary electrophoresis on microchips. Anal Chem, 2001, 73(11): 2656–2662

    Article  Google Scholar 

  8. Cui S L. Principle and Applied Technology of Optical Fiber Sensors (in Chinese). Harbin: Harbin Engineering University Press, 1995. 13–20

    Google Scholar 

  9. Wu D M. Optical Fiber Communication Principle and Technology (in Chinese). Beijing: Science Press, 2004. 8–15

    Google Scholar 

  10. Li H F, Lin J M, Su R G, et al. A compactly integrated laser-induced fluorescence detector for microchip electrophoresis. Electrophoresis, 2004, 25(12): 1907–1915

    Article  Google Scholar 

  11. Xiong S X, Li J J, Cheng J K. Engineering research of high-efficiency capillary electrophoresis-charge coupled device detector. Anal Sci J (in Chinese), 1995, 11(3): 12–15

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Supported by the key Technology R&D Program of Shanxi Province (Grant No. 052022)

About this article

Cite this article

Li, M. Fabrication technology of integrated fiber microfluidic electrophoresis chip. Chin. Sci. Bull. 52, 1925–1928 (2007). https://doi.org/10.1007/s11434-007-0235-8

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11434-007-0235-8

Keywords

Navigation