Abstract
Pulsed electromagnetic field can affect the proliferation of osteoblasts, but the mechanism is obscure yet. The communication between osteoblasts, isolated from calvaria bone of newborn SD rats and stimulated with the rectangular electromagnetic field of 15 Hz and 4 mT, was studied. Our results showed that the osteoblasts radiated a kind of light after they were stimulated with the electromagnetic field and it is the light that promotes the proliferation of un-stimulated osteoblasts.
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References
Inoue N, Ohnishi I, Chen D, et al. Effect of pulsed electromagnetic fields on late-phase osteotomy gap healing in a canine tibial model. J Orthop Res, 2002, 20: 1106–1114
Funk R H, Monsees T K. Effects of electromagnetic fields on cells: Physiological and therapeutical approaches and molecular mechanisms of interaction. A review. Cells Tissues Organs. 2006, 182(2): 59–78
Repacholi M H, Greenebaum B. Interaction of static and extremely low frequency electric and magnetic fields with living system: Health effects and research needs. Bioelectromagnetics, 1999, 20: 133–160
Panagopoulos D J, Karabarbounis A, Margaritis L H. Mechanism for action of electromagnetic fields on cells. Biochem Biophys Res Commun, 2002, 298: 95–102
Goodman R, Blank M. Insights into electromagnetic interaction mechanisms. J Cell Physiol, 2002, 192: 16–22
Zhuang H M, Wang W, Seldes R M, et al. Electrical stimulation induces the level of TGF-betal mRNA in osteoblastic cells by a mechanism involving Calcium/Calmodulin pathway. Biochem Biophys Res Commun, 1997, 237: 225–229
Khatib L, Golan D E, Cho M. Physiologic electrical stimulation provokes intracellular calcium increase mediated by phospholipase C activation in human osteoblasts. FASEB J, 2004, 18: 1903–1905
Brighton C T, Wang W, Seldes R, et al. Signal Transduction in electrically stimulated bone cells. J Bone Joint Surgery, 2001, 83: 1514–1523
Blank M, Goodman R. Initial interactions in electromagnetic field-induced biosynthesis. J Cell Physiol, 2004, 199: 359–363
Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay. J Immunol Methods, 1983, 65: 55–63
Chang W H, Chen L, Sun J, et al. Effect of pulse-burst electromagnetic field stimulation on osteoblast cell activities. Bioelectromagnetics, 2004, 25: 457–465
Zhang X J, Zhang J B, Wen J, et al. Effects of PEMF on the proliferation and diffrenciation of osteoblasts. Chin J Physl Med Rehib, 2006, 28(2): 79–81
Shen X, Mei W, Xu X. Activation of neutrophils by a chemically separated but optically coupled neutrophil population undergoing respiratory burst. Experientia, 1994, 50: 963–968
Bo J G, Yang J, Zhu D W, et al. The multiple interactions between growth factors and microenvironment in vivo. Chin Sci Bull, 2006, 51: 761–769
Lavi R, Shainberg A, Friedmann H, et al. Low energy visible light induces reactive oxygen species generation and stimulates an increase of intracellular calcium concentration in cardiac cells. J Biol Chem, 2003, 278: 40917–40922
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Supported by the National Natural Science Foundation of China (Grant Nos. 60171030 & 10672132)
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Zhang, J., Zhang, X. Communication between osteoblasts stimulated by electromagnetic fields. CHINESE SCI BULL 52, 98–100 (2007). https://doi.org/10.1007/s11434-007-0027-1
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DOI: https://doi.org/10.1007/s11434-007-0027-1