Abstract
Optical Doppler Tomography (ODT) provides a novel method to measure the blood flow velocity in vessels with the diameter at micrometer scale. Rats with cranial window are used as a model, and the changes in the blood flow velocity of cerebral arterioles in sensory cortex are measured in real time with an established ODT system, under electrical stimulation and drug administration. The results show significant differences in the blood flow velocity between experimental groups and control groups, demonstrating the feasibility of ODT in the cerebral microcirculation study. Compared with the conventional Doppler ultrasound, ODT provides much higher spatial resolution, and thus holds a promising future in the application of the cerebral microcirculation study, especially in the observation of the blood flow velocity in micrometer scale vessels.
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Supported by the National Hi-Tech Research and Development Program of China (863 Program)(Grant No. 2006AA02Z4E0), the National Natural Science Foundation of China (Grant Nos. 60378041, 60478040, 60878057 and 30770685), the Program for New Century Excellent Talents in University (Grant No. NCET-04-0528), and the Opening Project of MOE Key Laboratory of Laser Life Science, South China Normal University
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Meng, J., Ding, Z., Yang, Y. et al. Study on cerebral microcirculation by Optical Doppler Tomography. Sci. China Ser. G-Phys. Mech. Astron. 51, 1883–1891 (2008). https://doi.org/10.1007/s11433-008-0186-3
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DOI: https://doi.org/10.1007/s11433-008-0186-3