Abstract
The relationships between the morphological characteristics and the vulnerability of atherosclerotic plaque were analyzed theoretically and several suggestions were proposed to evaluate the plaque vulnerability. Validated by animal experiments and clinical studies, the theoretical results were confirmed.
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Christopher P C. Management of Acute Coronary Syndromes. New Jersey: Humana Press Inc, 1999
Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation, 2001, 104: 365–372
Ge J, Chirillo F, Schwedtmann J, et al. Screening of ruptured plaques in patients with coronary artery disease by intravascular ultrasound. Heart, 1999, 81: 621–627
Chen W Q, Zhang Y, Zhang M, et al. Establishing an animal model of unstable atherosclerotic plaques. Chin Med J, 2004, 117: 1293–1298
Richardson P D. Biomechanics of plaque rupture: Progress, problems, and new frontiers. Ann Biomed Eng, 2002, 30(4): 524–536
Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient—A call for new definitions and risk assessment strategies: Part I. Circulation, 2003, 108(14): 1664–1672
Zhang P F, Zhang Y. Current status on the progress in detection of arteriosclerotic vulnerable plaque with imaging techniques. Chin Med J (in Chinese), 2004, 84(13): 1140–1142
Pasterkamp G, Falk E. Atherosclerotic plaque rupture: An overview. J Clin Basic Cardiol, 2000, 3: 81–86
Su H J, Zhang M, Zhang Y. Mechanical model of vulnerable atherosclerotic plaque rupture. Sci China Ser G-Phys Mech Astron, 2004, 47(4): 452–462
Su H J, Zhang P F, Zhang M, et al. Higher-ordered dynamics of simplified mechanical model for vulnerable atherosclerosis plaque rupture. Chin J Biomed Eng, 2006, 25(3): 322–327
Chen W Q, Zhang Y, Zhang M, et al. Establishing an animal model of unstable atherosclerotic plaques. Chin Med J, 2004, 117(9): 1293–1298
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Supported by the National Natural Science Foundation of China (Grant Nos. 10302016 and 60402023), the National Basic Research Program of China (973 Program)(Grant No. 2006CB503803), and the National Hi-Tech Research and Development Program of China (863 Program) (Grant No. 2007AA02Z448)
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Su, H., Zhang, P., Chen, W. et al. Morphological study of atherosclerotic plaque and its application in vulnerability evaluation. Sci. China Ser. G-Phys. Mech. Astron. 51, 867–872 (2008). https://doi.org/10.1007/s11433-008-0079-5
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DOI: https://doi.org/10.1007/s11433-008-0079-5