Skip to main content
Log in

Wearable wireless real-time cerebral oximeter for measuring regional cerebral oxygen saturation

  • Research Paper
  • Published:
Science China Information Sciences Aims and scope Submit manuscript

Abstract

Monitoring regional cerebral oxygen saturation throughout the perioperative clinical process is important for successful patient outcomes. Cerebral oximeters based on near-infrared spectroscopy (NIRS) have already been used for monitoring brain oxygenation and hemodynamics to avoid intraoperative ischemic stroke and reduce postoperative cognitive dysfunction. The current devices are all designed to be used as a bedside monitor, limiting their use to situations that center around a hospital bed. There is a current lack of wearable, miniaturized, wireless equipment that can extend brain oxygenation monitoring to motion tasks or tight spaces. We design a head-mounted wearable wireless oxygen saturation monitoring on head (WORTH) band based on NIRS for monitoring regional cerebral oxygen saturation. The band is embedded with a highly integrated central block, which comprises an optical module, a microprocessor unit, a wireless communication module, and a power management module. The performance of the WORTH band is evaluated by a controlled hypoxia experiment and a squat-to-stand experiment. The results confirm that the WORTH band can record cerebral oxygen saturation with an accuracy comparable to that of a clinical monitor and demonstrate that it is also effective during motion tasks.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Raichle M E, Gusnard D A. Appraising the brain’s energy budget. Proc Natl Acad Sci USA, 2002, 99: 10237–10239

    Article  Google Scholar 

  2. Yücel M A, Selb J J, Huppert T J, et al. Functional near infrared spectroscopy: enabling routine functional brain imaging. Curr Opin Biomed Eng, 2017, 4: 78–86

    Article  Google Scholar 

  3. Jobsis F F. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science, 1977, 198: 1264–1267

    Article  Google Scholar 

  4. Pinti P, Tachtsidis I, Hamilton A, et al. The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience. Ann NY Acad Sci, 2020, 1464: 5–29

    Article  Google Scholar 

  5. Ferrari M, Quaresima V. A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application. Neuroimage, 2012, 63: 921–935

    Article  Google Scholar 

  6. Sanfilippo F, Serena G, Corredor C, et al. Cerebral oximetry and return of spontaneous circulation after cardiac arrest: a systematic review and meta-analysis. Resuscitation, 2015, 94: 67–72

    Article  Google Scholar 

  7. Steppan J, Hogue J C W. Cerebral and tissue oximetry. Best Practice Res Clin Anaesthesiol, 2014, 28: 429–439

    Article  Google Scholar 

  8. Koyama Y, Wada T, Lohman B D, et al. A new method to detect cerebral blood flow waveform in synchrony with chest compression by near-infrared spectroscopy during CPR. Am J Emergency Med, 2013, 31: 1504–1508

    Article  Google Scholar 

  9. Moerman A, de Hert S. Cerebral oximetrythe standard monitor of the future? Curr Opin Anaesthesiol, 2015, 28: 703–709

    Article  Google Scholar 

  10. Vranken N P A, Weerwind P W, Sutedja N A, et al. Cerebral oximetry and autoregulation during cardiopulmonary bypass: a review. J Extra-Corporeal Technol, 2017, 49: 182–191

    Google Scholar 

  11. Smith B, Vu E, Kibler K, et al. Does hypothermia impair cerebrovascular autoregulation in neonates during cardiopulmonary bypass? Pediatr Anaesth, 2017, 27: 905–910

    Article  Google Scholar 

  12. Tsai H I, Chung P C H, Lee C W, et al. Cerebral perfusion monitoring in acute care surgery: current and perspective use. Expert Rev Med Dev, 2016, 13: 865–875

    Article  Google Scholar 

  13. Zheng F, Sheinberg R, Yee M S, et al. Cerebral near-infrared spectroscopy monitoring and neurologic outcomes in adult cardiac surgery patients. Anesthesia Analgesia, 2013, 116: 663–676

    Article  Google Scholar 

  14. Parnia S, Yang J, Nguyen R, et al. Cerebral oximetry during cardiac arrest. Critical Care Med, 2016, 44: 1663–1674

    Article  Google Scholar 

  15. Mailhot T, Cossette S, Lambert J, et al. Cerebral oximetry as a biomarker of postoperative delirium in cardiac surgery patients. J Critical Care, 2016, 34: 17–23

    Article  Google Scholar 

  16. Denault A Y, Shaaban-Ali M, Cournoyer A, et al. Chapter 7 — Near-Infrared Spectroscopy in Neuromonitoring Techniques. Pittsburgh: Academic Press, 2018. 179–233

    Google Scholar 

  17. Hirose T, Shiozaki T, Nomura J, et al. Pre-hospital portable monitoring of cerebral regional oxygen saturation (rSO2) in seven patients with out-of-hospital cardiac arrest. BMC Res Notes, 2016, 9: 428

    Article  Google Scholar 

  18. Everdell N L, Airantzis D, Kolvya C, et al. A portable wireless near-infrared spatially resolved spectroscopy system for use on brain and muscle. Med Eng Phys, 2013, 35: 1692–1697

    Article  Google Scholar 

  19. Strangman G E, Ivkovic V, Zhang Q. Wearable brain imaging with multimodal physiological monitoring. J Appl Physiol, 2018, 124: 564–572

    Article  Google Scholar 

  20. Di H, Zhang X. Deception detection by hybrid-pair wireless fNIRS system. Int J Digital Crime Forensics, 2017, 9: 15–24

    Article  Google Scholar 

  21. Zhang X, Jiang T. Wearable wireless cerebral oximeter (conference presentation). In: Proceedings of SPIE, 2016. 9690

  22. Suzuki S, Takasaki S, Ozaki T, et al. Tissue oxygenation monitor using NIR spatially resolved spectroscopy. In: Proceedings of SPIE, 1999. 3597

  23. Williams I M, Picton A, Farrell A, et al. Light-reflective cerebral oximetry and jugular bulb venous oxygen saturation during carotid endarterectomy. Br J Surg, 1994, 81: 1291–1295

    Article  Google Scholar 

  24. Mccormick P W, Stewart M, Goetting M G, et al. Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and hemodynamics. Critical Care Med, 1991, 19: 89–97

    Article  Google Scholar 

  25. Ferrari M, Mottola L, Quaresima V. Principles, techniques, and limitations of near infrared spectroscopy. Can J Appl Physiol, 2004, 29: 463–487

    Article  Google Scholar 

  26. Wray S, Cope M, Delpy D T, et al. Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation. Biochim Biophysica Acta, 1988, 933: 184–192

    Article  Google Scholar 

  27. McCormick P W, Stewart M, Goetting M G, et al. Regional cerebrovascular oxygen saturation measured by optical spectroscopy in humans. Stroke, 1991, 22: 596–602

    Article  Google Scholar 

  28. Watzman H M, Kurth C D, Montenegro L M, et al. Arterial and venous contributions to near-infrared cerebral oximetry. Anesthesiology, 2000, 93: 947–953

    Article  Google Scholar 

  29. Benni P B, MacLeod D, Ikeda K, et al. A validation method for near-infrared spectroscopy based tissue oximeters for cerebral and somatic tissue oxygen saturation measurements. J Clin Monit Comput, 2018, 32: 269–284

    Article  Google Scholar 

  30. Kussman B D, Laussen P C, Benni P B, et al. Cerebral oxygen saturation in children with congenital heart disease and chronic hypoxemia. Anesthesia Analgesia, 2017, 125: 234–240

    Article  Google Scholar 

  31. Vretzakis G, Georgopoulou S, Stamoulis K, et al. Monitoring of brain oxygen saturation (INVOS) in a protocol to direct blood transfusions during cardiac surgery: a prospective randomized clinical trial. J Cardiothorac Surg, 2013, 8: 145

    Article  Google Scholar 

Download references

Acknowledgements

This work was partially supported by National Key Research and Development Program of China (Grant No. 2017YFB1002502), National Natural Science Foundation of China (Grant Nos. 31571003, U1636121), Key Programs of Science and Technology Commission Foundation of Beijing (Grant No. Z181100003818004), Supplementary and Supportive Project for Teachers at Beijing Information Science and Technology University (2018–2020) (Grant No. 5029011103), Beijing Municipal Education Commission Science and Technology Program (Grant Nos. KM202011232008, KM201911232019). We appreciate the English editing assistance of Drs. Rhoda E. and Edmund F. Perozzi.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Lianqing Zhu or Tianzi Jiang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Si, J., Zhang, X., Li, M. et al. Wearable wireless real-time cerebral oximeter for measuring regional cerebral oxygen saturation. Sci. China Inf. Sci. 64, 112203 (2021). https://doi.org/10.1007/s11432-020-2995-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11432-020-2995-5

Keywords

Navigation