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Two-dimensional copper metal-organic frameworks as antibacterial agents for biofilm treatment

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Abstract

Metal-organic frameworks (MOFs) composed of functional metal ions/clusters and suitable bridging ligands are highly designable, which have shown excellent catalytic activity as nanozymes and are promising for antibacterial therapy. Herein, two-dimensional (2D) copper MOF nanosheets (Cu-MOF NSs) as effective antibacterial agents were prepared through a simple one-step method. The 2D Cu-MOF NSs displayed a peroxidase-like activity toward H2O2 decomposition into highly cytotoxic hydroxyl radicals (•OH). Notably, the 2D morphology of Cu-MOF NSs provides a high density of Cu2+/Cu+ surface active sites, which could efficiently oxidize the proteins and lipids on the bacterial surface and induce the death of bacteria. It is found that the as-prepared 2D Cu-MOF NSs exhibited antibacterial properties against Staphylococcus aureus (S. aureus) and could efficiently eradicate the biofilm of S. aureus. Up to 99.9% bacteria were killed at a Cu-MOF concentration of 4 µg/mL. This study opens a new avenue for the design of MOF-based antibacterial agents to combat pathogenic bacterial infections.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China

    ZhengYuan Wang, Wei Guo, Kai Zhang, YingMin Ye, YanMin Wang, DanDan Sui, NaNa Zhao & Fu-Jian Xu

  2. College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China

    ZhengYuan Wang, Wei Guo, Kai Zhang, YingMin Ye, YanMin Wang, DanDan Sui, NaNa Zhao & Fu-Jian Xu

Authors
  1. ZhengYuan Wang
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  2. Wei Guo
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  3. Kai Zhang
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  4. YingMin Ye
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  5. YanMin Wang
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  6. DanDan Sui
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  7. NaNa Zhao
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Corresponding authors

Correspondence to Kai Zhang or NaNa Zhao.

Additional information

This work was supported by the National Natural Science Foundation of China (Grant Nos. 52173271, 51922022 and 51773013), the Beijing Outstanding Young Scientist Program (Grant No. BJJWZYJH0120191001-0024), the China Postdoctoral Science Foundation (Grant Nos. 2021T140044 and 2020M670110), the Beijing Municipal Natural Science Foundation (Grant No. 2214074), the Beijing Municipal Science and Technology Project (Grant No. Z191100006619099), and the Fundamental Research Funds for the Central Universities (Grant Nos. BHYC1705A and XK1802-2).

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Wang, Z., Guo, W., Zhang, K. et al. Two-dimensional copper metal-organic frameworks as antibacterial agents for biofilm treatment. Sci. China Technol. Sci. 65, 1052–1058 (2022). https://doi.org/10.1007/s11431-021-1963-3

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  • DOI: https://doi.org/10.1007/s11431-021-1963-3

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