Abstract
Electro-deposition, electrical activation, thermal oxidation, and reactive ion sputtering are the four primary methods to fabricate iridium oxide film. Among these methods, reactive ion sputtering is a commonly used method in standard micro-fabrication processes. In different sputtering conditions, the component, texture, and electrochemistry character of iridium oxide varies considerably. To fabricate the iridium oxide film compatible with the wafer-level processing of neural electrodes, the quality of iridium oxide film must be able to withstand the mechanical and chemical impact of post-processing, and simultaneously achieve good performance as a neural electrode. In this study, parameters of sputtering were researched and developed to achieve a balance between mechanical stability and good electrochemical characteristics of iridium oxide film on electrode. Iridium oxide fabricating process combined with fabrication flow of silicon electrodes, at wafer-level, is introduced to produce silicon based planar iridium oxide neural electrodes. Compared with bare gold electrodes, iridium oxide electrodes fabricated with this method exhibit particularly good electrochemical stability, low impedance of 386 kΩ at 1 kHz, high safe charge storage capacity of 3.2 mC/cm2, and good impedance consistency of less than 25% fluctuation.
Similar content being viewed by others
References
Verzeano M, Negishi K. Neuronal activity in cortical and thalamic networks. J Gen Physiol, 1960, 43: 177–195
Hoogerwerf A C, Wise K D. A three-dimensional microelectrode array for chronic neural recording. IEEE T Bio-Med Eng, 1994, 41: 1136–1146
Kozai T D, Langhals N B, Patel P R, et al. Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces. Nat Mater, 2012, 11: 1065–1073
Kipke D R, Vetter R J, Williams J C, et al. Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex. IEEE T Neur Sys Reh, 2003, 11: 151–155
Vetter R J, Williams J C, Hetke J F, et al. Chronic neural recording using silicon-substrate microelectrode arrays implanted in cerebral cortex. IEEE T Bio-Med Eng, 2004, 51: 896–904
Fujishiro A, Kaneko H, Kawashima T, et al. In vivo neuronal action potential recordings via three-dimensional microscale needleelectrode arrays. Scientific Reports, 2014, 4: 4868
Foley C P, Nishimura N, Neeves K B, et al. Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection- enhanced neural drug delivery. Biomed Microdevices, 2009, 11: 915–924
Shin J H, Kim G B, Lee E J, et al. Carbon-nanotube-modified electrodes for highly efficient acute neural recording. Adv Health Mater, 2014, 3: 245–252
Keefer E W, Botterman B R, Romero M I, et al. Carbon nanotube coating improves neuronal recordings. Nature Nanotechnol, 2008, 3: 434–439
Song P A, Yang H T, Fu S Y, et al. Effect of carbon nanotubes on the mechanical properties of polypropylene/wood flour composites: reinforcement mechanism. J Macromol Sci, 2011, 50: 907–921
Zhu L, Sun Y, Hess D W, et al. Well-aligned open-ended carbon nanotube architectures: an approach for device assembly. Nano Lett, 2006, 6: 243–247
Ludwig K A, Uram J D, Yang J, et al. Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film. J Neural Eng, 2006, 3: 59–70
Venkatraman S, Hendricks J, King Z A, et al. In vitro and in vivo evaluation of PEDOT microelectrodes for neural stimulation and recording. IEEE T Neur Sys Reh, 2011, 19: 307–316
Ludwig K A, Langhals N B, Joseph M D, et al. Poly(3,4-ethylenedioxythiophene) (PEDOT) polymer coatings facilitate smaller neural recording electrodes. J Neural Eng, 2011, 8: 014001
Harris A R, Morgan S J, Chen J, et al. Conducting polymer coated neural recording electrodes. J Neural Eng, 2013, 10: 016004
Cui X, Wiler J, Dzaman M, et al. In vivo studies of polypyrrole/ peptide coated neural probes. Biomaterials, 2003, 24: 777–787
Cui X, Martin D C. Fuzzy gold electrodes for lowering impedance and improving adhesion with electrodeposited conducting polymer films. Sensor Actuat B-Chem, 2003, 103: 384–394
Guo L, Ma M, Zhang N, et al. Stretchable polymeric multielectrode array for conformal neural interfacing. Adv Mater, 2014, 26: 1427–1433
Meyer R D, Cogan S F, Nguyen T H, et al. Electrodeposited iridium oxide for neural stimulation and recording electrodes. IEEE T Neur Sys Reh, 2001, 9: 2–11
Lu Y, Wang T, Cai Z, et al. Anodically electrodeposited iridium oxide films microelectrodes for neural microstimulation and recording. Sensor Actuat B-Chem, 2009, 137: 334–339
Yao S, Wang M, Madou M. A pH electrode based on melt-oxidized iridium oxide. Journal of the electrochemical society 2001, 148: H29–H36
Robblee L S, Mangaudis M J, Lasinsky E D, et al. Charge injection properties of thermally-prepared iridium oxide films. Mater Res Soc Symp Proc, 1986, 55: 303–310
Lee S H, Jung J H, Chae Y M, et al. Fabrication and characterization of implantable and flexible nerve cuff electrodes with Pt, Ir and IrOx films deposited by RF sputtering. J Micromech Microeng, 2010, 20: 035015
Slavcheva E, Vitushinsky R, Mokwa W, et al. Sputtered iridium oxide films as charge injection material for functional electrostimulation. J Electrochem Soc, 2004, 151: e226
Kang X, Liu J, Tian H, et al. Sputtered iridium oxide modified flexible parylene microelectrodes array for electrical recording and stimulation of muscles. Sensor Actuat B-Chem, 2016, 225: 267–278
Slavcheva E, Schnakenberg U, Mokwa W. Deposition of sputtered iridium oxide—Influence of oxygen flow in the reactor on the film properties. Appl Surf Sci, 2006, 253: 1964–1969
Negi S, Bhandari R, Rieth L, et al. Effect of sputtering pressure on pulsed-DC sputtered iridium oxide films. Sensor Actuat B-Chem, 2009, 137: 370–378
Pei W, Zhu L, Wang S, et al. Multi-channel micro neural probe fabricated with SOI. Sci China Ser-E Tech Sci, 2008, 52: 1187–1190
Jain A, Kim Y T, Mc Keon R J, et al. In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. Biomaterials, 2006, 27: 497–504
Lee I S, Park J M, Son H J, et al. Iridium oxide as a stimulating neural electrode formed by reactive magnetron sputtering. Key Eng Mater, 2005, 288: 307–310
Collier N, Callens D, Campistron P, et al. Ultrasonic adhesion measurement of whey protein fouling. Heat Transfer Eng, 2015, 36: 771–779
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zhang, H., Pei, W., Zhao, S. et al. Fabrication of iridium oxide neural electrodes at the wafer level. Sci. China Technol. Sci. 59, 1399–1406 (2016). https://doi.org/10.1007/s11431-016-6099-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11431-016-6099-x