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Therapie des Typ-1-Diabetes

Kurzfassung der S3-Leitlinie (AWMF-Registernummer: 057‑013; 2. Auflage)

Treatment of type 1 diabetes

Brief summary of the S3 guidelines (AWMF register number: 057-013; 2nd edition)

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Die Diabetologie Aims and scope

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Notes

  1. Diese Klassifikation geht auf Empfehlungen der Amerikanischen Diabetes-Gesellschaft (ADA) zurück.

  2. Für das Vorliegen einer diabetischen Ketoazidose werden international unterschiedliche Blutglukosegrenzwerte definiert. Der Grenzwert von 250 mg/dl (13,9 mmol/l) basiert auf dem Konsens der Autorengruppe. Da die klinischen Auswirkungen von hohen Blutglukosewerten stark variieren können, sollten die Blutglukosewerte auf der Grundlage des klinischen Bildes beurteilt werden. Eine einmalige Blutzuckermessung von mehr als 250 mg/dl (13,9 mmol/l) ohne entsprechende Begleitparameter ist noch keine Ketoazidose.

Literatur

  1. American Diabetes Association (2017) 2. Classification and diagnosis of diabetes. Diabetes Care 40(Suppl. 01):S11–S24

    Google Scholar 

  2. Johnson DD, Palumbo PJ, Chu CP (1980) Diabetic ketoacidosis in a community-based population. Mayo Clin Proc 55:83–88 (EK III)

    CAS  PubMed  Google Scholar 

  3. Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2:1279–1283 (EK III)

    CAS  PubMed  Google Scholar 

  4. Palmer JP, Asplin CM, Clemons P et al (1983) Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222:1337–1339 (EK III)

    CAS  PubMed  Google Scholar 

  5. Wiest-Ladenburger U, Hartmann R, Hartmann U et al (1997) Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test. Diabetes 46:565–571 (EK III)

    CAS  PubMed  Google Scholar 

  6. Bingley PJ, Bonifacio E, Mueller PW (2003) Diabetes Antibody Standardization Program: first assay proficiency evaluation. Diabetes 52:1128–1136 (EK III)

    CAS  PubMed  Google Scholar 

  7. Törn C, Mueller PW, Schlosser M et al (2008) Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen‑2. Diabetologia 51:846–852 (EK III)

    PubMed  Google Scholar 

  8. Schlosser M, Mueller PW, Torn C et al (2010) Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies. Diabetologia 53:2611–2620 (EK III)

    CAS  PubMed  Google Scholar 

  9. Imagawa A, Hanafusa T, Miyagawa J et al (2000) A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. N Engl J Med 342:301–307 (EK III)

    CAS  PubMed  Google Scholar 

  10. National Institute for Health and Clinical Excellence (2015) Type 1 diabetes in adults: diagnosis and management (EK IV)

    Google Scholar 

  11. American Diabetes Association (2017) Standards of medical care in diabetes—2017. Diabetes Care 40:1 (EK IV)

    Google Scholar 

  12. DCCT Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329:977–986 (EK Ib)

    Google Scholar 

  13. Fanelli CG, Epifano L, Rambotti AM et al (1993) Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes 42:1683–1689 (EK IIb)

    CAS  PubMed  Google Scholar 

  14. Fritsche A, Stefan N, Häring H et al (2001) Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med 134:729–736 (EK IIb)

    CAS  PubMed  Google Scholar 

  15. Deutsche Diabetes Gesellschaft. S2k-Leitlinie Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Alter. Angemeldete Leitlinie in Entstehung. Im Internet:. http://www.awmf.org/leitlinien/detail/anmeldung/1/ll/057-017.html. EK IV

  16. Lipska KJ, Hirsch IB, Riddle MC (2017) Human insulin for type 2 diabetes: an effective, less-expensive option. JAMA 318:23–24 (EK IV/LoE 4)

    PubMed  Google Scholar 

  17. Lucidi P, Porcellati F, Marinelli Andreoli A et al (2015) Pharmacokinetics and pharmacodynamics of NPH insulin in type 1 diabetes: the importance of appropriate resuspension before subcutaneous injection. Diabetes Care 38:2204–2210 (EK IV)

    CAS  PubMed  Google Scholar 

  18. Wutte A, Plank J, Sinner F (2004) Dose-response relationship and within-subject variability of insulin detemir and NPH insulin in subjects with Type 1 diabetes. Diabetes 53(Suppl. 02):A152 (EK IV)

    Google Scholar 

  19. Becker RHA, Frick AD (2008) Clinical pharmacokinetics and pharmacodynamics of insulin glulisine. Clin Pharmacokinet 47:7–20 (EK III)

    CAS  PubMed  Google Scholar 

  20. Weyer C, Heise T, Heinemann L (1997) Insulin aspart in a 30/70 premixed formulation. Pharmacodynamic properties of a rapid-acting insulin analog in stable mixture. Diabetes Care 20:1612–1614 (EK III)

    CAS  PubMed  Google Scholar 

  21. Woodworth JR, Howey DC, Bowsher RR et al (1994) Comparative pharmacokinetics and glucodynamics of two human insulin mixtures. 70/30 and 50/50 insulin mixtures. Diabetes Care 17:366–371 (EK II)

    CAS  PubMed  Google Scholar 

  22. Heise T, Hövelmann U, Nosek L et al (2015) Comparison of the pharmacokinetic and pharmacodynamic profiles of insulin degludec and insulin glargine. Expert Opin Drug Metab Toxicol 11:1193–1201 (EK III)

    CAS  PubMed  Google Scholar 

  23. Haahr H, Heise T (2014) A review of the pharmacological properties of insulin degludec and their clinical relevance. Clin Pharmacokinet 53:787–800 (EK I)

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Nosek L, Coester HV, Roepstorff C et al (2014) Glucose-lowering effect of insulin degludec is independent of subcutaneous injection region. Clin Drug Investig 34:673–679 (EK II)

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Koehler G, Treiber G, Wutte A et al (2014) Pharmacodynamics of the long-acting insulin analogues detemir and glargine following single-doses and under steady-state conditions in patients with type 1 diabetes. Diabetes Obes Metab 16:57–62 (EK II)

    CAS  PubMed  Google Scholar 

  26. Heise T, Pieber TR (2007) Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies. Diabetes Obes Metab 9:648–659 (EK I)

    CAS  PubMed  Google Scholar 

  27. Becker RHA, Dahmen R, Bergmann K et al (2015) New insulin glargine 300 Units · mL‑1 provides a more even activity profile and prolonged glycemic control at steady state compared with insulin glargine 100 Units · mL-1: The ELEMENT 1 study. Diabetes Care 38:637–643 (EK II)

    CAS  PubMed  Google Scholar 

  28. Shiramoto M, Eto T, Irie S et al (2015) Single-dose new insulin glargine 300 U/ml provides prolonged, stable glycaemic control in Japanese and European people with type 1 diabetes. Diabetes Obes Metab 17:254–260 (EK II)

    CAS  PubMed  Google Scholar 

  29. Heise T, Pieber TR, Danne T et al (2017) A pooled analysis of clinical pharmacology trials investigating the pharmacokinetic and pharmacodynamic characteristics of fast-acting insulin Aspart in adults with type 1 diabetes. Clin Pharmacokinet 56:551–559 (EK II)

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Heise T, Eckers U, Kanc K et al (2008) The pharmacokinetic and pharmacodynamic properties of different formulations of biphasic insulin aspart: A randomized, glucose clamp, crossover study. Diabetes Technol Ther 10:479–485 (EK II)

    CAS  PubMed  Google Scholar 

  31. Famulla S, Hovelmann U, Fischer A et al (2016) Insulin injection into lipohypertrophic tissue: blunted and more variable insulin absorption and action and impaired postprandial glucose control. Diabetes Care 39:1486–1492 (EK II/LoE)

    CAS  PubMed  Google Scholar 

  32. Heise T, Weyer C, Serwas A et al (1998) Time-action profiles of novel premixed preparations of insulin Lispro and NPL insulin. Diabetes Care 21:800–803 (EK III)

    CAS  PubMed  Google Scholar 

  33. Rave K, Heinemann L, Puhl L et al (1999) Premixed formulations of insulin lispro. Activity profiles in type 1 diabetic patients. Diabetes Care 22:865–866 (EK III)

    CAS  PubMed  Google Scholar 

  34. Brunner M, Pieber T, Korsatko S et al (2015) The distinct prandial and basal pharmacodynamics of IDegasp observed in younger adults are preserved in elderly subjects with type 1 diabetes. Drugs Aging 32:583–590 (EK II)

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Heise T, Nosek L, Roepstorff C et al (2014) Distinct prandial and basal glucose-lowering effects of insulin degludec/insulin aspart (IDegasp) at steady state in subjects with type 1 diabetes mellitus. Diabetes Ther 5:255–265 (EK II)

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (2007) Kurzwirksame Insulinanaloga zur Behandlung des Diabetes mellitus Typ 1. Abschlussbericht. Auftrag A05-02. Version 1.0 (EK Ia)

    Google Scholar 

  37. Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (2010) Langwirksame Insulinanaloga zur Behandlung des Diabetes mellitus Typ 1. Abschlussbericht. Auftrag A05-01. Version 1.0 (EK Ia)

    Google Scholar 

  38. Singh SR, Ahmad F, Lal A et al (2009) Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis. CMAJ 180:385–397 (EK Ia)

    PubMed  PubMed Central  Google Scholar 

  39. Monami M, Marchionni N, Mannucci E (2009) Long-acting insulin analogues vs. NPH human insulin in type 1 diabetes. A meta-analysis. Diabetes Obes Metab 11:372–378 (EK Ia)

    CAS  PubMed  Google Scholar 

  40. Mullins P, Sharplin P, Yki-Jarvinen H et al (2007) Negative binomial meta-regression analysis of combined glycosylated hemoglobin and hypoglycemia outcomes across eleven Phase III and IV studies of insulin glargine compared with neutral protamine Hagedorn insulin in type 1 and type 2 diabetes mellitus. Clin Ther 29:1607–1619 (EK Ia)

    CAS  PubMed  Google Scholar 

  41. Ashwell SG, Bradley C, Stephens JW et al (2008) Treatment satisfaction and quality of life with insulin glargine plus insulin lispro compared with NPH insulin plus unmodified human insulin in individuals with type 1 diabetes. Diabetes Care 31:1112–1117 (EK Ib)

    CAS  PubMed  Google Scholar 

  42. Hermansen K, Fontaine P, Kukolja KK et al (2004) Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with type 1 diabetes. Diabetologia 47:622–629 (EK Ib)

    CAS  PubMed  Google Scholar 

  43. Bühn S, Breuing J, Mathes T et al (2016) Evidenzbericht zu ausgewählten Rechercheaufträgen im Rahmen der S3-Leitlinie „Therapie des Typ-1-Diabetes“. IFOM – Institut für Forschung in der Operativen Medizin (Universität Witten/Herdecke), Witten/Herdecke

    Google Scholar 

  44. Fullerton B, Siebenhofer A, Jeitler K et al (2016) Short-acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD012161 (EK Ia/LoE 1++)

    Article  PubMed  PubMed Central  Google Scholar 

  45. Vardi M, Jacobson E, Nini A et al (2008) Intermediate acting versus long acting insulin for type 1 diabetes mellitus. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD006297.pub2 (EK Ia/LoE 1+)

    Article  PubMed  PubMed Central  Google Scholar 

  46. Retnakaran R, Hochman J, DeVries JH et al (2004) Continuous subcutaneous insulin infusion versus multiple daily injections: the impact of baseline A1c. Diabetes Care 27:2590–2596 (EK Ia)

    CAS  PubMed  Google Scholar 

  47. Fatourechi MM, Kudva YC, Murad MH et al (2009) Clinical review: Hypoglycemia with intensive insulin therapy: a systematic review and meta-analyses of randomized trials of continuous subcutaneous insulin infusion versus multiple daily injections. J Clin Endocrinol Metab 94:729–740 (EK Ia)

    CAS  PubMed  Google Scholar 

  48. Jeitler K, Horvath K, Berghold A et al (2008) Continuous subcutaneous insulin infusion versus multiple daily insulin injections in patients with diabetes mellitus: systematic review and meta-analysis. Diabetologia 51:941–951 (EK Ia)

    CAS  PubMed  Google Scholar 

  49. Pickup JC, Sutton AJ (2008) Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. Diabet Med 25:765–774 (EK IIb)

    CAS  PubMed  Google Scholar 

  50. Bolli GB, Kerr D, Thomas R et al (2009) Comparison of a multiple daily insulin injection regimen (basal once-daily glargine plus mealtime lispro) and continuous subcutaneous insulin infusion (lispro) in type 1 diabetes: a randomized open parallel multicenter study. Diabetes Care 32:1170–1176 (EK Ib)

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Steineck I, Cederholm J, Eliasson B et al (2015) Insulin pump therapy, multiple daily injections, and cardiovascular mortality in 18168 people with type 1 diabetes: observational study. BMJ 350:h3234 (EK IIb)

    PubMed  PubMed Central  Google Scholar 

  52. Barnard KD, Lloyd CE, Skinner TC (2007) Systematic literature review: quality of life associated with insulin pump use in type 1 diabetes. Diabet Med 24:607–617 (EK Ia)

    CAS  PubMed  Google Scholar 

  53. Hoogma RP, Hammond PJ, Gomis R et al (2006) Comparison of the effects of continuous subcutaneous insulin infusion (CSII) and NPH-based multiple daily insulin injections (MDI) on glycaemic control and quality of life: results of the 5‑nations trial. Diabet Med 23:141–147 (EK Ib)

    CAS  PubMed  Google Scholar 

  54. Mukhopadhyay A, Farrell T, Fraser RB et al (2007) Continuous subcutaneous insulin infusion vs intensive conventional insulin therapy in pregnant diabetic women: a systematic review and metaanalysis of randomized, controlled trials. Am J Obstet Gynecol 197:447–456 (EK Ia)

    CAS  PubMed  Google Scholar 

  55. Farrar D, Tuffnell DJ, West J (2007) Continuous subcutaneous insulin infusion versus multiple daily injections of insulin for pregnant women with diabetes. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD005542.pub3 (EK Ia)

    Article  PubMed  Google Scholar 

  56. Chen R, Ben-Haroush A, Weismann-Brenner A et al (2007) Level of glycemic control and pregnancy outcome in type 1 diabetes: a comparison between multiple daily insulin injections and continuous subcutaneous insulin infusions. Am J Obstet Gynecol 197:404–405 (EK IIb)

    Google Scholar 

  57. Cypryk K, Kosinski M, Kaminska P et al (2008) Diabetes control and pregnancy outcomes in women with type 1 diabetes treated during pregnancy with continuous subcutaneous insulin infusion or multiple daily insulin injections. Pol Arch Med Wewn 118:339–344 (EK IIb)

    CAS  PubMed  Google Scholar 

  58. Gimenez M, Conget I, Nicolau J et al (2007) Outcome of pregnancy in women with type 1 diabetes intensively treated with continuous subcutaneous insulin infusion or conventional therapy. A case-control study. Acta Diabetol 44:34–37 (EK III)

    CAS  PubMed  Google Scholar 

  59. Alto WA, Meyer D, Schneid J et al (2002) Assuring the accuracy of home glucose monitoring. J Am Board Fam Pract 15:1–6 (EK III)

    PubMed  Google Scholar 

  60. Saudek CD, Derr RL, Kalyani RR (2006) Assessing glycemia in diabetes using self-monitoring blood glucose and hemoglobin A1c. JAMA 295:1688–1697 (EK IV)

    CAS  PubMed  Google Scholar 

  61. Bundesärztekammer, Kassenärztliche Bundesvereinigung, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften Nationale VersorgungsLeitlinie Diabetes – Strukturierte Schulungsprogramme – Langfassung, 1. Auflage. Version 4. EK IV. http://www.dm-schulung.versorgungsleitlinien.de. Zugegriffen: 4. Nov. 2017

  62. Kulzer B, Albus C, Herpertz S et al (2013) Psychosoziales und Diabetes (Teil 1). Diabetologie 8:198–242 (EK IV)

    Google Scholar 

  63. Kulzer B, Albus C, Herpertz S et al (2013) Psychosoziales und Diabetes (Teil 2). Diabetologie 8:292–324 (EK IV)

    Google Scholar 

  64. Hermanns N, Kulzer B, Krichbaum M (2008) Problemspezifische Patientenschulung. Übersicht zu einem wesentlichen Bestandteil der Diabetestherapie. Diabetologe 4:361–367 (EK III)

    Google Scholar 

  65. American Diabetes Association (2017) 14. Diabetes Care in the Hospital. Diabetes Care 40(Suppl. 1):S120–S127 (EK IV)

    Google Scholar 

  66. Chen HS, Wu TE, Jap TS et al (2008) Effects of health education on glycemic control during holiday time in patients with type 2 diabetes mellitus. Am J Manag Care 14:45–51 (EK Ib/LoE)

    PubMed  Google Scholar 

  67. Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. http://guidelines.diabetes.ca/app_themes/cdacpg/resources/cpg_2013_full_en.pdf. Zugegriffen: 23. Juli 2017 (EK IV)

  68. Graveling AJ, Frier BM (2009) Hypoglycaemia: an overview. Prim Care Diabetes 3:131–139 (EK III)

    PubMed  Google Scholar 

  69. Cryer PE (2008) The barrier of hypoglycemia in diabetes. Diabetes 57:3169–3176 (EK III)

    CAS  PubMed  PubMed Central  Google Scholar 

  70. Deary IJ, Hepburn DA, MacLeod KM et al (1993) Partitioning the symptoms of hypoglycaemia using multi-sample confirmatory factor analysis. Diabetologia 36:771–777 (EK III/LoE 3)

    CAS  PubMed  Google Scholar 

  71. McAulay V, Deary IJ, Frier BM (2001) Symptoms of hypoglycaemia in people with diabetes. Diabet Med 18:690–705 (EK III)

    CAS  PubMed  Google Scholar 

  72. Haak T, Kellerer M, Deutsche Diabetes Gesellschaft (2009) Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Kindes- und Jugendalter. Kirchheim, Mainz (EK IV)

    Google Scholar 

  73. Kitabchi AE, Umpierrez GE, Murphy MB et al (2006) Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association. Diabetes Care 29:2739–2748 (EK IV)

    CAS  PubMed  Google Scholar 

  74. Kitabchi AE, Umpierrez GE, Miles JM et al (2009) Hyperglycemic crises in adult patients with diabetes. Diabetes Care 32:1335–1343 (EK IV)

    CAS  PubMed  PubMed Central  Google Scholar 

  75. Bull SV, Douglas IS, Foster M et al (2007) Mandatory protocol for treating adult patients with diabetic ketoacidosis decreases intensive care unit and hospital lengths of stay: results of a nonrandomized trial. Crit Care Med 35:41–46 (EK IIb)

    PubMed  Google Scholar 

  76. Joint British Diabetes Societies for inpatient care The management of diabetic ketoacidosis in adults. Second edition update: September 2013. http://www.diabetologists-abcd.org.uk/JBDS/JBDS_IP_DKA_Adults_Revised.pdf. Zugegriffen: 23. Sept. 2017 (EK IV)

  77. Bundesärztekammer, Kassenärztliche Bundesvereinigung, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (2010) Nationale VersorgungsLeitlinie Typ-2-Diabetes – Nierenerkrankungen bei Diabetes im Erwachsenenalter. Version Konsultation 1.0 (EK IV)

    Google Scholar 

  78. Bundesärztekammer, Kassenärztliche Bundesvereinigung, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften Nationale VersorgungsLeitlinie Prävention und Therapie von Netzhautkomplikationen bei Diabetes – Langfassung, 2. Auflage. Version 2. EK IV. http://www.netzhautkomplikationen.versorgungsleitlinien.de. Zugegriffen: 19. Okt. 2017

  79. Bundesärztekammer, Kassenärztliche Bundesvereinigung, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (2010) Nationale VersorgungsLeitlinie Neuropathie bei Diabetes im Erwachsenenalter (EK IV)

    Google Scholar 

  80. Bundesärztekammer, Kassenärztliche Bundesvereinigung, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (2006) Nationale VersorgungsLeitlinie Typ-2-Diabetes – Präventions- und Behandlungsstrategien für Fuβkomplikationen. Version 2.8 (EK IV)

    Google Scholar 

  81. Bundesärztekammer, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, Kassenärztliche Bundesvereinigung (2010) Nationale VersorgungsLeitlinie Nierenerkrankungen bei Diabetes im Erwachsenenalter (EK IV)

    Google Scholar 

  82. Linnebjerg H, Zhang Q, LaBell E et al (2020) Pharmacokinetics and glucodynamics of ultra rapid Lispro (URLi) versus humalog (Lispro) in younger adults and elderly patients with type 1 diabetes mellitus: a Randomised controlled trial. Clin Pharmacokinet 59:1589–1599

    CAS  PubMed  PubMed Central  Google Scholar 

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Dieser Beitrag wurde erstpubliziert in Diabetologie und Stoffwechsel (2022) 17(Suppl 2):S133–144, https://doi.org/10.1055/a-1916-2101. Nachdruck mit freundl. Genehmigung von Georg Thieme Verlag KG. Die Urheberrechte liegen bei den Autorinnen und Autoren.

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Haak, T., Gölz, S., Fritsche, A. et al. Therapie des Typ-1-Diabetes. Diabetologie 19, 647–657 (2023). https://doi.org/10.1007/s11428-023-01046-z

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