Skip to main content
SpringerLink
Log in

Neues zur Endokrinologe

Für die Diabetologie interessante Aspekte

New developments in endocrinology

Aspects relevant to diabetology

  • Leitthema
  • Published:
Der Diabetologe Aims and scope

Zusammenfassung

Hintergrund

Neue Daten bzw. Leitlinien in der Endokrinologie werden dargestellt und diskutiert.

Themenbereiche

Insbesondere die Diagnosestellung und Therapie der subklinischen/latenten Hypothyreose, Neuigkeiten zum Thema Schilddrüse und Schwangerschaft, Empfehlungen zur Abklärung von Schilddrüsenknoten, eine neue Leitlinie zum Inzidentalom der Nebennieren, eine neue Leitlinie zur Diagnostik und Therapie des primären Hyperaldosteronismus, eine neue Leitlinie zur Behandlung der Nebennierenrindeninsuffizienz, neue Medikamente zur Behandlung der Osteoporose und Empfehlungen zur Prophylaxe von Kiefernekrosen durch Bisphosphonate und Denosumab werden abgehandelt.

Empfehlungen für die Praxis

Zu all den oben genannten Themenbereichen wurden jeweils Empfehlungen für die Praxis formuliert.

Abstract

Background

This article presents and discusses new data and guidelines in endocrinology.

Topics

The article deals in particular with the diagnosis and treatment of subclinical/latent hypothyroidism; new developments regarding the thyroid gland and pregnancy; recommendations on the evaluation and diagnosis of thyroid nodules; a new guideline on adrenal gland neoplasms; the diagnosis and treatment of primary hyperaldosteronism; a new guideline on the treatment of adrenocortical insufficiency; new drugs to treat osteoporosis; as well as recommendations on the prevention of osteonecrosis of the jaw when using bisphosphonates or denosumab.

Practical recommendations

Practical recommendations have been formulated for each of the above-mentioned topics.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2

Literatur

  1. Stott DJ, Rodondi N, Kearney PM et al (2017) Thyroid hormone therapy for older adults with subclinical hypothyroidism. N Engl J Med. doi:10.1056/NEJMoa1603825

    PubMed  Google Scholar 

  2. Tunbridge WMG, Evered DC, Hall R et al (1977) The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7(6):481–493

    Article  CAS  Google Scholar 

  3. Vanderpump M, Tunbridge W, French J et al (1995) The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol 43:55–68

    Article  CAS  Google Scholar 

  4. Canaris GJ, Mabowitz NR, Mayor G et al (2000) The colorado disease prevalence study. Arch Intern Med 160(4):526–534

    Article  CAS  PubMed  Google Scholar 

  5. Joffe R, Pearce E, Hennessey J et al (2013) Subclinical hypothyroidism, mood, and cognition in older adults: a review. Int J Geriatr Psychiatry 28:111–118

    Article  PubMed  Google Scholar 

  6. Rodondi N, den Elzen WP, Bauer DC et al (2010) Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 304:1365–1374

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ehrenkranz J, Bach PR, Snow GL et al (2015) Circadian and circannual rhythms in thyroid hormones: determining the TSH and free T4 reference intervals based upon time of day, age, and sex. Thyroid 25:954–961

    Article  CAS  PubMed  Google Scholar 

  8. Mirjanic-Azaric B, Stojakovic-Jelisavac T, Vukovic B et al (2015) The impact of time of sample collection on the measurement of thyroid stimulating hormone values in the serum. Clin Biochem 48:1347–1349

    Article  CAS  PubMed  Google Scholar 

  9. Pearce S, Brabant G, Duntas L (2013) 2013 ETA guideline: management of subclinical hypothyroidism. Eur Thyroid J 2:215–228

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Somwaru LL, Rariy C, Arnold A et al (2012) The natural history of subclinical hypothyroidism in the elderly: the Cardiovascular Health Study. J Clin Endocrinol Metab 97:1962–1969

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Diez J, Iglesias P (2004) Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure. J Clin Endocrinol Metab 89:4890–4897

    Article  CAS  PubMed  Google Scholar 

  12. Javed Z, Sathyapalam T (2016) Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Ther Adv Endocrinol Metab 7:12–23

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Helfand M, U.S. Preventative Services Task Force (2014) Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventative Services Task Force. Ann Intern Med 140:128–141

    Article  Google Scholar 

  14. Fatourechi V (2009) Subclinical hypothyroidism: an update for primary care physicians. Mayo Clin Proc 84:65–71

    Article  PubMed  PubMed Central  Google Scholar 

  15. Lee RH, Spencer C, Mestman JH et al (2009) Free T4 immunoassays are flawed during pregnancy. Am J Obstet Gynecol 200:260.e1–260.e6

    Article  Google Scholar 

  16. Anckaert E, Poppe K, Van Uyfanghe K et al (2010) Immunoassays may display a pattern during pregnancy similar to the equilibrium dialysis IDLC/tandem MS candidate reference measurement procedure in spite of susceptibility towards binding protein alterations. Clin Chim Acta 411:1348–1353

    Article  CAS  PubMed  Google Scholar 

  17. Alexander EK, Pearce EN, Brent GA et al (2016) 2016 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. doi:10.1089/thy.2016.0457

    Google Scholar 

  18. Tudela CM, Casey BM, McIntire DD et al (2012) Relationship of subclinical thyroid disease and the incidence of gestational diabetes. Obstet Gynecol 119:983–988

    Article  CAS  PubMed  Google Scholar 

  19. Allan WC, Haddow JE, Polomaki GR et al (2000) Maternal thyroid deficiency and pregnancy complications: implications for population screening. J Med Screen 7:127–130

    Article  CAS  PubMed  Google Scholar 

  20. Haddow JE, Polomaki GE, Allan WC et al (1999) Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549–555

    Article  CAS  PubMed  Google Scholar 

  21. Maraka S, Ospina NMS, O’Keeffe DT et al (2017) Subclinical hypothyroidism in pregnancy: A systematic review and meta-analysis. Thyroid 26(4):580–590

    Article  Google Scholar 

  22. Blatt AJ, Nakamoto JM, Kaufman HW et al (2012) National status of testing for hypothyroidism during pregnancy and postpartum. J Clin Endocrinol Metab 97:777–784

    Article  CAS  PubMed  Google Scholar 

  23. Li C, Shan Z, Mao J et al (2014) Assessment of thyroid function during first trimester pregnancy: what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women? J Clin Endocrinol Metab 99:73–79

    Article  CAS  PubMed  Google Scholar 

  24. Korevaar TI, Medici M, Peeters RP (2015) Subclinical hypothyroidism overdiagnosis in pregnant women. JAMA Intern Med 175:1872–1873

    Article  PubMed  Google Scholar 

  25. Casey BM, Thom EA, Peaceman AM et al (2017) Treatment of subclinical hypothyroidism or hypothyroxinemia in pregnancy. N Engl J Med 376:815–825

    Article  PubMed  Google Scholar 

  26. Cooper DS, Pearce EN (2017) Subclinical hypothyroidism and hypothyroxemia in pregnancy – still no answers. N Engl J Med 376(9):876–877

    Article  PubMed  Google Scholar 

  27. Nazarpour S, Ramezani Tehrani F, Simbar M et al (2017) Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease. Eur J Endocrinol 176:253–265

    Article  CAS  PubMed  Google Scholar 

  28. Tan S, Dieterle S, Pechlavanis S et al (2014) Thyroid autoantibodies per se do not impair intracytoplasmic sperm injection outcome in euthyroid healthy women. Eur J Endocrinol 170(4):495–500

    Article  CAS  PubMed  Google Scholar 

  29. Andersen SL, Olsen J, Laurberg P (2016) Antithyroid drug side effects in the population and in pregnancy. J Clin Endocrinol Metab 101(4):1606–1614

    Article  PubMed  Google Scholar 

  30. Haugen BR, Alexander EK, Bible KC et al (2016) 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26(1):1–133

    Article  PubMed  PubMed Central  Google Scholar 

  31. Feldkamp J, Führer D, Luster M et al (2016) Fine needle aspiration in the investigation of thyroid nodules. Indications, procedures, and interpretation. Dtsch Arztebl Int 113(20):353–359

    PubMed  PubMed Central  Google Scholar 

  32. Fagin J, Wells S (2016) Biological and clinical perspectives on thyroid cancer. N Engl J Med 375:1054–1067

    Article  CAS  PubMed  Google Scholar 

  33. Fassnacht M, Arlt W, Bancos I et al (2016) Management of adrenal icidentalomas: European Society of Endocrinology Clinical Practice Guidelines in collaboration with the European Network for the Study of Adrenal Tumors. Eur J Endocrinol 175(2):G1–G34

    Article  PubMed  Google Scholar 

  34. Funder JW, Carey RM, Mantero F et al (2016) The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 101(5):1889–1916

    Article  CAS  PubMed  Google Scholar 

  35. Bornstein SR, Allolio B, Arlt W et al (2016) Management of primary adrenal insufficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 101:364–389

    Article  CAS  PubMed  Google Scholar 

  36. Broersen LH, Pereira AM, Jorgenen JO et al (2015) Adrenal insufficiency in corticosteroids use: systematic review and meta–analysis. J Clin Endocrinol Metab 100:2171–2180

    Article  CAS  PubMed  Google Scholar 

  37. Miller PD (2016) Underdiagnosis and undertreatment of osteoporosis. The battle to be won. J Clin Endocrinol Metab 101(3):852–859

    Article  CAS  PubMed  Google Scholar 

  38. Khan A, Morrison A, Cheung A et al (2016) Osteonecosis of the jaw (ONJ): diagnosis and management in 2015. Osteoporos Int 27(3):853–859

    Article  CAS  PubMed  Google Scholar 

  39. Sim IW, Sanders KM, Borromeo GL et al (2015) Declining incidence of medication-related osteonecrosis of the jaw in patients with cancer. J Clin Endocrinol Metab 100(10):3887–3893

    Article  CAS  PubMed  Google Scholar 

  40. Tsai JN, Uihlein AV, Lee H et al (2013) Teripatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial. Lancet 382:50–56

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Tsai JN, UIhlein AV, Burnett-Bowie SM et al (2016) Effects of two years of Teripatide, Denosumab, or both on bone microarchitecture and strength (DATA-HRpQCT study). J Clin Endocrinol Metab 101(5):2023–2030

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Leder BZ, Tsai JN, Uihlein AV et al (2015) Denosumab and teriparatide transitions in postmenopausal oseoporosis (the DATA-Switch study): extension of a randomised controlled trial. Lancet 386(9999):1147–1155

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Cosman F, Crittenden DB, Aachi JD et al (2016) Romosozumab treatment in postmenopausal women with osteoporosis. N Engl J Med 375:1532–1543

    Article  CAS  PubMed  Google Scholar 

  44. Miller PD, Hattersley G, Riis BJ et al (2016) ACTIVE Study Investigators. Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: A randomized clinical trial. JAMA 316(7):722–733

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Endokrinologie & Stoffwechselerkrankungen und Zentrallabor (Forschung und Lehre), Universitätsklinikum Essen, Essen, Deutschland

    D. Führer

  2. Universitätsklinikum, Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland

    W. A. Scherbaum

Authors
  1. D. Führer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. A. Scherbaum
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to W. A. Scherbaum.

Ethics declarations

Interessenkonflikt

D. Führer und W.A. Scherbaum geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Führer, D., Scherbaum, W.A. Neues zur Endokrinologe. Diabetologe 13, 342–354 (2017). https://doi.org/10.1007/s11428-017-0235-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11428-017-0235-5

Schlüsselwörter

Keywords

Search

Navigation