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Local field potentials, spiking activity, and receptive fields in human visual cortex

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Abstract

The concept of receptive field (RF) is central to sensory neuroscience. Neuronal RF properties have been substantially studied in animals, while those in humans remain nearly unexplored. Here, we measured neuronal RFs with intracranial local field potentials (LFPs) and spiking activity in human visual cortex (V1/V2/V3). We recorded LFPs via macro-contacts and discovered that RF sizes estimated from low-frequency activity (LFA, 0.5–30 Hz) were larger than those estimated from low-gamma activity (LGA, 30–60 Hz) and high-gamma activity (HGA, 60–150 Hz). We then took a rare opportunity to record LFPs and spiking activity via microwires in V1 simultaneously. We found that RF sizes and temporal profiles measured from LGA and HGA closely matched those from spiking activity. In sum, this study reveals that spiking activity of neurons in human visual cortex could be well approximated by LGA and HGA in RF estimation and temporal profile measurement, implying the pivotal functions of LGA and HGA in early visual information processing.

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Acknowledgement

This work was supported by the National Science and Technology Innovation 2030 Major Program (2022ZD0204802, 2022ZD0204804), the National Natural Science Foundation of China (31930053, 32171039), and Beijing Academy of Artificial Intelligence (BAAI).

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Authors and Affiliations

  1. School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China

    Lu Luo, Junshi Lu, Guanpeng Chen, Qian Wang & Fang Fang

  2. School of Psychology, Beijing Sport University, Beijing, 100084, China

    Lu Luo

  3. Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, China

    Xiongfei Wang & Guoming Luan

  4. Beijing Key Laboratory of Epilepsy, Epilepsy Center, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, China

    Xiongfei Wang & Guoming Luan

  5. IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China

    Junshi Lu, Guanpeng Chen, Qian Wang & Fang Fang

  6. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China

    Guanpeng Chen & Fang Fang

  7. Beijing Institute for Brain Disorders, Beijing, 100069, China

    Guoming Luan

  8. State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China

    Wu Li

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Luo, L., Wang, X., Lu, J. et al. Local field potentials, spiking activity, and receptive fields in human visual cortex. Sci. China Life Sci. 67, 543–554 (2024). https://doi.org/10.1007/s11427-023-2436-x

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