References
Deb, D., Mackey, D., Opiyo, S.O., and McDowell, J.M. (2018). Application of alignment-free bioinformatics methods to identify an oomycete protein with structural and functional similarity to the bacterial AvrE effector protein. PLoS ONE 13, e0195559.
He, J., Ye, W., Choi, D.S., Wu, B., Zhai, Y., Guo, B., Duan, S., Wang, Y., Gan, J., Ma, W., et al. (2019). Structural analysis of Phytophthora suppressor of RNA silencing 2 (PSR2) reveals a conserved modular fold contributing to virulence. Proc Natl Acad Sci USA 116, 8054–8059.
Jin, L., Ham, J.H., Hage, R., Zhao, W., Soto-Hernández, J., Lee, S.Y., Paek, S.M., Kim, M.G., Boone, C., Coplin, D.L., et al. (2016). Direct and indirect targeting of PP2A by conserved bacterial type-III effector proteins. PLoS Pathog 12, e1005609.
Jiang, R.H.Y., Tripathy, S., Govers, F., and Tyler, B.M. (2008). RXLR effector reservoir in two Phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members. Proc Natl Acad Sci USA 105, 4874–4879.
Kamoun, S., Furzer, O., Jones, J.D.G., Judelson, H.S., Ali, G.S., Dalio, R.J. D., Roy, S.G., Schena, L., Zambounis, A., Panabières, F., et al. (2015). The top 10 oomycete pathogens in molecular plant pathology. Mol Plant Pathol 16, 413–434.
Li, H., Wang, J., Kuan, T.A., Tang, B., Feng, L., Wang, J., Cheng, Z., Skłenar, J., Derbyshire, P., Hulin, M., et al. (2023). Pathogen protein modularity enables elaborate mimicry of a host phosphatase. Cell 186, 3196–3207.e17.
Máthé, C., Freytag, C., Kelemen, A., M-Hamvas, M., and Garda, T. (2023). “B” regulatory subunits of PP2A: their roles in plant development and stress reactions. Int J Mol Sci 24, 5147.
O’Connor, C.M., Perl, A., Leonard, D., Sangodkar, J., and Narla, G. (2018). Therapeutic targeting of PP2A. Int J Biochem Cell Biol 96, 182–193.
Perez-Quintero, A.L., and Szurek, B. (2019). A decade decoded: spies and hackers in the history of TAL effectors research. Annu Rev Phytopathol 57, 459–481.
Qiao, Y., Liu, L., Xiong, Q., Flores, C., Wong, J., Shi, J., Wang, X., Liu, X., Xiang, Q., Jiang, S., et al. (2013). Oomycete pathogens encode RNA silencing suppressors. Nat Genet 45, 330–333.
Shi, Y. (2009). Serine/threonine phosphatases: mechanism through structure. Cell 139, 468–484.
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This work was supported by the National Key Research and Development Program of China (2021YFA1300700).
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Bi, G., Zhou, JM. Effector modularity promotes functional diversification and evolutionary processes. Sci. China Life Sci. 66, 2955–2957 (2023). https://doi.org/10.1007/s11427-023-2424-9
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DOI: https://doi.org/10.1007/s11427-023-2424-9