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A rational consideration of the genomic instability of human-induced pluripotent stem cells for clinical applications

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References

  • Guo, R., Ye, X., Yang, J., Zhou, Z., Tian, C., Wang, H., Wang, H., Fu, H., Liu, C., Zeng, M., et al. (2018). Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells. Nat Commun 9, 2620.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jin, Z.B., Gao, M.L., Deng, W.L., Wu, K.C., Sugita, S., Mandai, M., and Takahashi, M. (2019). Stemming retinal regeneration with pluripotent stem cells. Prog Retin Eye Res 69, 38–56.

    Article  CAS  PubMed  Google Scholar 

  • Keller, A., and Spits, C. (2021). The impact of acquired genetic abnormalities on the clinical translation of human pluripotent stem cells. Cells 10, 3246.

    Article  PubMed  PubMed Central  Google Scholar 

  • Liuyang, S., Wang, G., Wang, Y., He, H., Lyu, Y., Cheng, L., Yang, Z., Guan, J., Fu, Y., Zhu, J., et al. (2023). Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming. Cell Stem Cell 30, 450–459.e9.

    Article  CAS  PubMed  Google Scholar 

  • Martins-Taylor, K., Nisler, B.S., Taapken, S.M., Compton, T., Crandall, L., Montgomery, K.D., Lalande, M., and Xu, R.H. (2011). Recurrent copy number variations in human induced pluripotent stem cells. Nat Biotechnol 29, 488–491.

    Article  CAS  PubMed  Google Scholar 

  • Martins-Taylor, K., and Xu, R.H. (2012). Concise review: genomic stability of human induced pluripotent stem cells. Stem Cells 30, 22–27.

    Article  CAS  PubMed  Google Scholar 

  • Moradi, S., Mahdizadeh, H., Šarić, T., Kim, J., Harati, J., Shahsavarani, H., Greber, B., and Moore IV, J.B. (2019). Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations. Stem Cell Res Ther 10, 341.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rouhani, F.J., Zou, X., Danecek, P., Badja, C., Amarante, T.D., Koh, G., Wu, Q., Memari, Y., Durbin, R., Martincorena, I., et al. (2022). Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells. Nat Genet 54, 1406–1416.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Thompson, O., von Meyenn, F., Hewitt, Z., Alexander, J., Wood, A., Weightman, R., Gregory, S., Krueger, F., Andrews, S., Barbaric, I., et al. (2020). Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions. Nat Commun 11, 1528.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao, T., Zhang, Z., Westenskow, P.D., Todorova, D., Hu, Z., Lin, T., Rong, Z., Kim, J., He, J., Wang, M., et al. (2015). Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells. Cell Stem Cell 17, 353–359.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China

    Hang Zhang & Zi-Bing Jin

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  1. Hang Zhang
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  2. Zi-Bing Jin
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Correspondence to Zi-Bing Jin.

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Compliance and ethics The author(s) declare that they have no conflict of interest. The figure was created with https://biorender.com.

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Zhang, H., Jin, ZB. A rational consideration of the genomic instability of human-induced pluripotent stem cells for clinical applications. Sci. China Life Sci. 66, 2198–2200 (2023). https://doi.org/10.1007/s11427-023-2354-6

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  • DOI: https://doi.org/10.1007/s11427-023-2354-6

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