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The shadows hang over immunotherapy-neutrophil extracellular traps in cancer

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References

  • Castanheira, F.V.S., and Kubes, P. (2019). Neutrophils and NETs in modulating acute and chronic inflammation. Blood 133, 2178–2185.

    Article  CAS  PubMed  Google Scholar 

  • Kaltenmeier, C., Yazdani, H.O., Morder, K., Geller, D.A., Simmons, R.L., and Tohme, S. (2021). Neutrophil extracellular traps promote T cell exhaustion in the tumor microenvironment. Front Immunol 12, 785222.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McDowell, S.A.C., Luo, R.B.E., Arabzadeh, A., Doré, S., Bennett, N.C., Breton, V., Karimi, E., Rezanejad, M., Yang, R.R., Lach, K.D., et al. (2021). Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration. Nat Cancer 2, 545–562.

    Article  CAS  PubMed  Google Scholar 

  • Miller-Ocuin, J.L., Liang, X., Boone, B.A., Doerfler, W.R., Singhi, A.D., Tang, D., Kang, R., Lotze, M.T., and Zeh Iii, H.J. (2019). DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth. Oncoimmunology 8, e1605822.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ng, M.S.F., Tan, L., Wang, Q., Mackay, C.R., and Ng, L.G. (2021). Neutrophils in cancer—unresolved questions. Sci China Life Sci 64, 1829–1841.

    Article  CAS  PubMed  Google Scholar 

  • Park, J., Wysocki, R.W., Amoozgar, Z., Maiorino, L., Fein, M.R., Jorns, J., Schott, A.F., Kinugasa-Katayama, Y., Lee, Y., Won, N.H., et al. (2016). Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med 8.

  • Ren, J., He, J., Zhang, H., Xia, Y., Hu, Z., Loughran, P., Billiar, T., Huang, H., and Tsung, A. (2021). Platelet TLR4-ERK5 axis facilitates NET-mediated capturing of circulating tumor cells and distant metastasis after surgical stress. Cancer Res 81, 2373–2385.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stehr, A.M., Wang, G., Demmler, R., Stemmler, M.P., Krug, J., Tripal, P., Schmid, B., Geppert, C.I., Hartmann, A., Muñoz, L.E., et al. (2022). Neutrophil extracellular traps drive epithelial-mesenchymal transition of human colon cancer. J Pathol 256, 455–467.

    Article  CAS  PubMed  Google Scholar 

  • Teijeira, Á., Garasa, S., Gato, M., Alfaro, C., Migueliz, I., Cirella, A., de Andrea, C., Ochoa, M.C., Otano, I., Etxeberria, I., et al. (2020). CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity. Immunity 52, 856–871.e8.

    Article  CAS  PubMed  Google Scholar 

  • Wang, H., Zhang, H., Wang, Y., Brown, Z.J., Xia, Y., Huang, Z., Shen, C., Hu, Z., Beane, J., Ansa-Addo, E.A., et al. (2021). Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis. J Hepatol 75, 1271–1283.

    Article  CAS  PubMed  Google Scholar 

  • Wang, Z., Yang, C., Li, L., Jin, X., Zhang, Z., Zheng, H., Pan, J., Shi, L., Jiang, Z., Su, K., et al. (2020). Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer. Oncogenesis 9, 82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xia, Y., He, J., Zhang, H., Wang, H., Tetz, G., Maguire, C.A., Wang, Y., Onuma, A., Genkin, D., Tetz, V., et al. (2020). AAV-mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response. Mol Oncol 14, 2920–2935.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xiao, Y., Cong, M., Li, J., He, D., Wu, Q., Tian, P., Wang, Y., Yang, S., Liang, C., Liang, Y., et al. (2021). Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell 39, 423–437.e7.

    Article  CAS  PubMed  Google Scholar 

  • Yazdani, H.O., Roy, E., Comerci, A.J., van der Windt, D.J., Zhang, H., Huang, H., Loughran, P., Shiva, S., Geller, D.A., Bartlett, D.L., et al. (2019). Neutrophil extracellular traps drive mitochondrial homeostasis in tumors to augment growth. Cancer Res 79, 5626–5639.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang, Y., Chandra, V., Riquelme Sanchez, E., Dutta, P., Quesada, P.R., Rakoski, A., Zoltan, M., Arora, N., Baydogan, S., Horne, W., et al. (2020). Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med 217.

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Acknowledgements

This work was supported by the 1-3-5 Project for Disciplines of Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University (2020HXFH046), Regional Innovation Cooperation Project of Sichuan Science and Technology Program (2021YFQ0029), and the National Natural Science Foundation of China (82103413).

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  1. Contributed equally to this work

Authors and Affiliations

  1. Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, 610000, China

    Dan Pu, Liyuan Yin, Xiaoqian Zhai, Lin Huang, Qiang Wu, Lingling Zhu, Qinghua Zhou & Lu Li

  2. Uro-Oncology Research, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA

    Ruoxiang Wang

  3. Oncology Department, West China Hospital, Sichuan University, Chengdu, 610000, China

    Yuwen Zhou

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  1. Dan Pu
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  2. Liyuan Yin
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  10. Lu Li
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Correspondence to Lu Li.

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Pu, D., Yin, L., Zhai, X. et al. The shadows hang over immunotherapy-neutrophil extracellular traps in cancer. Sci. China Life Sci. 66, 1196–1199 (2023). https://doi.org/10.1007/s11427-022-2243-4

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  • DOI: https://doi.org/10.1007/s11427-022-2243-4

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