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A tRF oligomerizes Nucleolin to stabilize metastasis-favoring transcripts

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References

  • Chen, J., Guo, K., and Kastan, M.B. (2012). Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. J Biol Chem 287, 16467–16476.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ivanov, P., Emara, M.M., Villen, J., Gygi, S.P., and Anderson, P. (2011). Angiogenin-induced tRNA fragments inhibit translation initiation. Mol Cell 43, 613–623.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li, J., Zhu, L., Cheng, J., and Peng, Y. (2021). Transfer RNA-derived small RNA: a rising star in oncology. Semin Cancer Biol 75, 29–37.

    Article  CAS  PubMed  Google Scholar 

  • Li, Y., Luo, J., Zhou, H., Liao, J.Y., Ma, L.M., Chen, Y.Q., and Qu, L.H. (2008). Stress-induced tRNA-derived RNAs: a novel class of small RNAs in the primitive eukaryote Giardia lamblia. Nucl Acids Res 36, 6048–6055.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu, X., Mei, W., Padmanaban, V., Alwaseem, H., Molina, H., Passarelli, M.C., Tavora, B., and Tavazoie, S.F. (2022). A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs. Mol Cell 82, 2604–2617.e8.

    Article  CAS  PubMed  Google Scholar 

  • Maute, R.L., Schneider, C., Sumazin, P., Holmes, A., Califano, A., Basso, K., and Dalla-Favera, R. (2013). tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proc Natl Acad Sci USA 110, 1404–1409.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mongelard, F., and Bouvet, P. (2007). Nucleolin: a multiFACeTed protein. Trends Cell Biol 17, 80–86.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, X., He, X., Liu, C., Liu, J., Hu, Q., Pan, T., Duan, X., Liu, B., Zhang, Y., Chen, J., et al. (2016). IL-4 inhibits the biogenesis of an epigenetically suppressive PIWI-interacting RNA to upregulate CD1a molecules on monocytes/dendritic cells. J Immunol 196, 1591–1603.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (82273168), the Science and Technology Foundation of Sichuan Province, China (2022YFS0046) and the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYGD20008).

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Authors and Affiliations

  1. Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China

    Jiawei Guo & Yong Peng

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  1. Jiawei Guo
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  2. Yong Peng
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Correspondence to Yong Peng.

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Guo, J., Peng, Y. A tRF oligomerizes Nucleolin to stabilize metastasis-favoring transcripts. Sci. China Life Sci. 66, 646–648 (2023). https://doi.org/10.1007/s11427-022-2234-7

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  • DOI: https://doi.org/10.1007/s11427-022-2234-7

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