Skip to main content
SpringerLink
Log in

Cuproptosis: copper-induced regulated cell death

  • Research Highlight
  • Published:
Science China Life Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Gou, D.H., Huang, T.T., Li, W., Gao, X.D., Haikal, C., Wang, X.H., Song, D.Y., Liang, X., Zhu, L., Tang, Y., et al. (2021). Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson’s disease. Redox Biol 38, 101795.

    Article  CAS  Google Scholar 

  • Rowland, E.A., Snowden, C.K., and Cristea, I.M. (2018). Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease. Curr Opin Chem Biol 42, 76–85.

    Article  CAS  Google Scholar 

  • Sun, W.Y., Tyurin, V.A., Mikulska-Ruminska, K., Shrivastava, I.H., Anthonymuthu, T.S., Zhai, Y.J., Pan, M.H., Gong, H.B., Lu, D.H., Sun, J., et al. (2021). Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal. Nat Chem Biol 17, 465–476.

    Article  CAS  Google Scholar 

  • Tajima, K., Ikeda, K., Chang, H.Y., Chang, C.H., Yoneshiro, T., Oguri, Y., Jun, H., Wu, J., Ishihama, Y., and Kajimura, S. (2019). Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nat Metab 1, 886–898.

    Article  CAS  Google Scholar 

  • Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R.D., et al. (2022). Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375, 1254–1261.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou, 510632, China

    Wen-Jun Duan & Rong-Rong He

  2. Jinan University, Guangzhou, 510632, China

    Wen-Jun Duan & Rong-Rong He

  3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

    Wen-Jun Duan & Rong-Rong He

  4. School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China

    Wen-Jun Duan & Rong-Rong He

Authors
  1. Wen-Jun Duan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rong-Rong He
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rong-Rong He.

Ethics declarations

Compliance and ethics The author(s) declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Duan, WJ., He, RR. Cuproptosis: copper-induced regulated cell death. Sci. China Life Sci. 65, 1680–1682 (2022). https://doi.org/10.1007/s11427-022-2106-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11427-022-2106-6

Search

Navigation