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Advancements in endometrial epithelial stem cell research

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References

  • Cao, Y., Sun, H., Zhu, H., Zhu, X., Tang, X., Yan, G., Wang, J., Bai, D., Wang, J., Wang, L., et al. (2018). Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther 9, 192.

    Article  Google Scholar 

  • Fayazi, M., Salehnia, M., and Ziaei, S. (2017). In-vitro construction of endometrial-like epithelium using CD146+ mesenchymal cells derived from human endometrium. Reprod Biomed Online 35, 241–252.

    Article  CAS  Google Scholar 

  • Jiang, P., Tang, X., Wang, H., Dai, C., Su, J., Zhu, H., Song, M., Liu, J., Nan, Z., Ru, T., et al. (2019). Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study. Sci China Life Sci 62, 1617–1629.

    Article  CAS  Google Scholar 

  • Jin, S. (2019). Bipotent stem cells support the cyclical regeneration of endometrial epithelium of the murine uterus. Proc Natl Acad Sci USA 116, 6848–6857.

    Article  CAS  Google Scholar 

  • Nguyen, H.P.T., Xiao, L., Deane, J.A., Tan, K.S., Cousins, F.L., Masuda, H., Sprung, C.N., Rosamilia, A., and Gargett, C.E. (2017). N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays. Hum Reprod 32, 2254–2268.

    Article  CAS  Google Scholar 

  • Ong, Y.R., Cousins, F.L., Yang, X., Mushafi, A.A.A.A., Breault, D.T., Gargett, C.E., and Deane, J.A. (2018). Bone marrow stem cells do not contribute to endometrial cell lineages in chimeric mouse models. Stem Cells 36, 91–102.

    Article  CAS  Google Scholar 

  • Seishima, R., Leung, C., Yada, S., Murad, K.B.A., Tan, L.T., Hajamohideen, A., Tan, S.H., Itoh, H., Murakami, K., Ishida, Y., et al. (2019). Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development. Nat Commun 10, 5378.

    Article  Google Scholar 

  • Syed, S.M., Kumar, M., Ghosh, A., Tomasetig, F., Ali, A., Whan, R.M., Alterman, D., and Tanwar, P.S. (2020). Endometrial Axin2+ cells drive epithelial homeostasis, regeneration, and cancer following oncogenic transformation. Cell Stem Cell 26, 64–80.e13.

    Article  CAS  Google Scholar 

  • Tal, R., Shaikh, S., Pallavi, P., Tal, A., López-Giráldez, F., Lyu, F., Fang, Y. Y., Chinchanikar, S., Liu, Y., Kliman, H.J., et al. (2019). Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLoS Biol 17, e3000421.

    Article  CAS  Google Scholar 

  • Tempest, N., Baker, A.M., Wright, N.A., and Hapangama, D.K. (2018). Does human endometrial LGR5 gene expression suggest the existence of another hormonally regulated epithelial stem cell niche? Hum Reprod 33, 1052–1062.

    Article  CAS  Google Scholar 

  • Tempest, N., Jansen, M., Baker, A.M., Hill, C.J., Hale, M., Magee, D., Treanor, D., Wright, N.A., and Hapangama, D.K. (2020). Histological3D reconstruction and in vivo lineage tracing of the human endometrium. J Pathol 251, 440–451.

    Article  CAS  Google Scholar 

  • Yin, M., Zhou, H.J., Lin, C., Long, L., Yang, X., Zhang, H., Taylor, H., and Min, W. (2019). CD34+KLF4+ stromal stem cells contribute to endometrial regeneration and repair. Cell Rep 27, 2709–2724.e3.

    Article  CAS  Google Scholar 

  • Zhao, G., Cao, Y., Zhu, X., Tang, X., Ding, L., Sun, H., Li, J., Li, X., Dai, C., Ru, T., et al. (2017). Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman’s syndrome. Sci China Life Sci 60, 404–416.

    Article  CAS  Google Scholar 

  • Zhao, G., Li, R., Cao, Y., Song, M., Jiang, P., Wu, Q., Zhou, Z., Zhu, H., Wang, H., Dai, C., et al. (2020). ΔNp63α-induced DUSP4/GSK3β/SNAI1 pathway in epithelial cells drives endometrial fibrosis. Cell Death Dis 11, 449.

    Article  CAS  Google Scholar 

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Acknowledgements

We are grateful to SERVIER MEDICAL ART for kindly providing the single-cell pattern diagrams in Figure 1. This research and the APC were funded by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16040302) and the National Natural Science Foundation of China (81971336).

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Authors and Affiliations

  1. Nanjing University Medical School, Nanjing, 210008, China

    Xiwen Zhang

  2. Department of Obstetrics and Gynecology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China

    Guangfeng Zhao & Yali Hu

Authors
  1. Xiwen Zhang
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  2. Guangfeng Zhao
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  3. Yali Hu
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Correspondence to Yali Hu.

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The author(s) declare that they have no conflict of interest.

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Zhang, X., Zhao, G. & Hu, Y. Advancements in endometrial epithelial stem cell research. Sci. China Life Sci. 65, 215–218 (2022). https://doi.org/10.1007/s11427-021-1988-1

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  • DOI: https://doi.org/10.1007/s11427-021-1988-1

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