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YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock

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References

  • Beutler, B., and Rietschel, E.T. (2003). Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 3, 169–176.

    Article  CAS  Google Scholar 

  • Ding, S., Yan, W., Fang, J., Jiang, H., and Liu, G. (2021). Potential role of Lactobacillus plantarum in colitis induced by dextran sulfate sodium through altering gut microbiota and host metabolism in murine model. Sci China Life Sci doi: https://doi.org/10.1007/s11427-020-1835-4.

  • Guan, G., Ding, S., Yin, Y., Duraipandiyan, V., Al-Dhabi, N.A., and Liu, G. (2019). Macleaya cordata extract alleviated oxidative stress and altered innate immune response in mice challenged with enterotoxigenic Escherichia coli. Sci China Life Sci 62, 1019–1027.

    Article  CAS  Google Scholar 

  • Han, D., Liu, J., Chen, C., Dong, L., Liu, Y., Chang, R., Huang, X., Liu, Y., Wang, J., Dougherty, U., et al. (2019). Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature 566, 270–274.

    Article  CAS  Google Scholar 

  • Huang, H., Weng, H., and Chen, J. (2020). The biogenesis and precise control of RNA m6A methylation. Trends Genets 36, 44–52.

    Article  CAS  Google Scholar 

  • Kayagaki, N., Stowe, I.B., Lee, B.L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q.T., et al. (2015). Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666–671.

    Article  CAS  Google Scholar 

  • Mangan, M.S.J., Olhava, E.J., Roush, W.R., Seidel, H.M., Glick, G.D., and Latz, E. (2018). Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov 17, 588–606.

    Article  CAS  Google Scholar 

  • Munitz, A., McBride, M.L., Bernstein, J.S., and Rothenberg, M.E. (2008). A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils. Blood 111, 5694–5703.

    Article  CAS  Google Scholar 

  • Patil, D.P., Pickering, B.F., and Jaffrey, S.R. (2018). Reading m6A in the transcriptome: m6A-binding proteins. Trends Cell Biol 28, 113–127.

    Article  CAS  Google Scholar 

  • Shao, B.Z., Wang, S.L., Pan, P., Yao, J., Wu, K., Li, Z.S., Bai, Y., and Linghu, E.Q. (2019). Targeting NLRP3 inflammasome in inflammatory bowel disease: putting out the fire of inflammation. Inflammation 42, 1147–1159.

    Article  Google Scholar 

  • Shi, H., Zhang, X., Weng, Y.L., Lu, Z., Liu, Y., Lu, Z., Li, J., Hao, P., Zhang, Y., Zhang, F., et al. (2018). m6A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature 563, 249–253.

    Article  CAS  Google Scholar 

  • Shi, H., Wei, J., and He, C. (2019). Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers. Mol Cell 74, 640–650.

    Article  CAS  Google Scholar 

  • Shulman, Z., and Stern-Ginossar, N. (2020). The RNA modification N6-methyladenosine as a novel regulator of the immune system. Nat Immunol 21, 501–512.

    Article  CAS  Google Scholar 

  • Singer, M., Deutschman, C.S., Seymour, C.W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G.R., Chiche, J.D., Coopersmith, C.M., et al. (2016). The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315, 801–810.

    Article  CAS  Google Scholar 

  • Wang, X., Zhao, B.S., Roundtree, I.A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., and He, C. (2015). N6-methyladenosine modulates messenger RNA translation efficiency. Cell 161, 1388–1399.

    Article  CAS  Google Scholar 

  • Wu, C., Chen, W., He, J., Jin, S., Liu, Y., Yi, Y., Gao, Z., Yang, J., Yang, J., Cui, J., et al. (2020). Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection. Sci Adv 6, eaba0647.

    Article  CAS  Google Scholar 

  • Zhu, T., Roundtree, I.A., Wang, P., Wang, X., Wang, L., Sun, C., Tian, Y., Li, J., He, C., and Xu, Y. (2014). Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell Res 24, 1493–1496.

    Article  CAS  Google Scholar 

  • Zong, X., Zhao, J., Wang, H., Lu, Z., Wang, F., Du, H., and Wang, Y. (2019). Mettl3 deficiency sustains long-chain fatty acid absorption through suppressing Traf6-dependent inflammation response. J Immunol 202, 567–578.

    Article  CAS  Google Scholar 

  • Zong, X., Wang, H., Xiao, X., Zhang, Y., Hu, Y., Wang, F., Wang, Y., and Lu, Z. (2021). Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis. RNA Biol 18, 576–586.

    Article  CAS  Google Scholar 

  • Zou, L., Xiong, X., Yang, H., Wang, K., Zhou, J., Lv, D., and Yin, Y. (2019). Identification of microRNA transcriptome reveals that miR-100 is involved in the renewal of porcine intestinal epithelial cells. Sci China Life Sci 62, 816–828.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (32002185 and 31630075), Zhejiang Provincial Natural Science Foundation of China (LQ21C170002), and China Postdoctoral Science Foundation (2020M671741).

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Authors and Affiliations

  1. Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China

    Xin Zong, Xiao Xiao, Fu Jie, Yuanzhi Cheng, Mingliang Jin & Yizhen Wang

  2. Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410081, China

    Yulong Yin

  3. Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China

    Xin Zong, Xiao Xiao, Fu Jie, Yuanzhi Cheng, Mingliang Jin & Yizhen Wang

Authors
  1. Xin Zong
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  2. Xiao Xiao
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  3. Fu Jie
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  4. Yuanzhi Cheng
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  5. Mingliang Jin
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  6. Yulong Yin
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  7. Yizhen Wang
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Corresponding authors

Correspondence to Yulong Yin or Yizhen Wang.

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The author(s) declare that they have no conflict of interest.

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YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock, approximately 4.97 MB.

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Zong, X., Xiao, X., Jie, F. et al. YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock. Sci. China Life Sci. 64, 1988–1991 (2021). https://doi.org/10.1007/s11427-020-1909-6

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  • DOI: https://doi.org/10.1007/s11427-020-1909-6

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