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A natural nanozyme in life is found: the iron core within ferritin shows superoxide dismutase catalytic activity

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Acknowledgements

This work was supported by Sanming Project of Medicine in Shenzhen (SZSM201612031), Chinese Academy of Sciences (YJKYYQ20180048), the National Natural Science Foundation of China (81722024, 81772736 and 81571728), the Basic Research Foundation for Shenzhen’s Science and Technology (20190726095103499), Project of CAS Laboratory for Nanozyme (KFJ-PTXM-013), the National Key Research and Development Program of China (2017YFA0205501, 2017YFA0205503), the Key Research Program of Frontier Sciences of Chinese Academy of Sciences (QYZDY-SSW-SMC013), and the Youth Innovation Promotion Association (2014078). We thank Dr. Chenhui Ju (Institute of Biophysics, Chinese Academy of Sciences) for critical reading of the manuscript. We thank Dr. Xiaotian Yu (Guangdong provincial people’s hospital), Dr. Yuan Liu (Joint Laboratory of Nanozymes in Zhengzhou University) and Dr. Yuqiang Xiang (Joint Laboratory of Nanozymes in Zhengzhou University) for advice on statistical analyses.

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  1. Contributed equally to this work

Authors and Affiliations

  1. CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China

    Jianlin Zhang, Shimin Li & Xiyun Yan

  2. Institute of Translational Medicine, Shenzhen Second People’s Hospital, The First Affiliation Hospital of Shenzhen University, Health Science Center, Shenzhen, 518035, China

    Jianlin Zhang, Ni Xie, Guohui Nie & Aifa Tang

  3. Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China

    Jianlin Zhang

  4. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China

    Jianlin Zhang, Shimin Li & Xian-En Zhang

  5. University of Chinese Academy of Sciences, Beijing, 100049, China

    Shimin Li

  6. Shenzhen Luohu Hospital Group, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, 518001, China

    Aifa Tang

  7. Experimental Center of Advanced Materials, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 100081, China

    Minmin Liang

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  1. Jianlin Zhang
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Corresponding authors

Correspondence to Aifa Tang, Xian-En Zhang, Minmin Liang or Xiyun Yan.

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Zhang, J., Li, S., Xie, N. et al. A natural nanozyme in life is found: the iron core within ferritin shows superoxide dismutase catalytic activity. Sci. China Life Sci. 64, 1375–1378 (2021). https://doi.org/10.1007/s11427-020-1865-2

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  • DOI: https://doi.org/10.1007/s11427-020-1865-2

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