Article PDF
Avoid common mistakes on your manuscript.
References
Burchill, L.J., Velkoska, E., Dean, R.G., Griggs, K., Patel, S.K., and Burrell, L.M. (2012). Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions. Clin Sci 123, 649–658.
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395, 507–513.
Fang, L., Karakiulakis, G., and Roth, M. (2020). Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med 8, e21.
Fu, Y., Cheng, Y., and Wu, Y. (2020). Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol Sin 35, 266–271.
Jiang, F., Yang, J., Zhang, Y., Dong, M., Wang, S., Zhang, Q., Liu, F.F., Zhang, K., and Zhang, C. (2014). Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets. Nat Rev Cardiol 11, 413–426.
Liu, Y., Yang, Y., Zhang, C., Huang, F., Wang, F., Yuan, J., Wang, Z., Li, J., Li, J., Feng, C., et al. (2020). Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci 63, 364–374.
Lopez Santi, R.G., Valeff, E.C., Duymovich, C.R., Mazziotta, D., Mijailovsky, N.E., Filippa, G.C., Maltez, R., Hernandez, V.A., Monroy, A.G., Borzi, J.G., et al. (2005). Effects of an angiotensinconverting enzyme inhibitor (ramipril) on inflammatory markers in secondary prevention patients: RAICES Study. Coronary Artery Dis 16, 423–429.
Ruan, Q., Yang, K., Wang, W., Jiang, L., and Song, J. (2020). Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med 46, 846–848.
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 323, 1061–1069.
Yang, J.M., Meng, X., Xue, F., Zhang, Y., and Zhang, C. (2020). ACE2 in the context of 2019-nCoV infection: friend or foe? Zhonghua Xin Xue Guan Bing Za Zhi 48, 527–531.
Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Zhu, Y., Li, B., Huang, C.L., et al. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270–273.
Acknowledgements
We thank all patients involved in this study. This study was supported by the Program of Introducing Talents of Discipline to Universities (BP 0719033), the State Key Program of the National Natural Science Foundation of China (81530014) and the International Collaboration and Exchange Program of China (81920108003).
Author information
Authors and Affiliations
Corresponding authors
Additional information
Compliance and ethics
The author(s) declare that they have no conflict of interest.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Meng, X., Liu, Y., Wei, C. et al. Angiotensin converting enzyme inhibitors and angiotensin receptor blockers improved the outcome of patients with severe COVID-19 and hypertension. Sci. China Life Sci. 64, 836–839 (2021). https://doi.org/10.1007/s11427-020-1813-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-020-1813-0