References
Baker, K.D., and Thummel, C.S. (2007). Diabetic larvae and obese flies—Emerging studies of metabolism in Drosophila. Cell Metab 6, 257–266.
Baribault, H. (2016). Mouse models of type 2 diabetes mellitus in drug discovery. In: Proetzel, G., Wiles, M.V., eds. Mouse Models for Drug Discovery. Methods in Molecular Biology. New York: Humana Press, 153–175.
Honegger, B., Galic, M., Köhler, K., Wittwer, F., Brogiolo, W., Hafen, E., and Stocker, H. (2008). Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J Biol 7, 10.
Jia, W., Weng, J., Zhu, D., Ji, L., Lu, J., Zhou, Z., Zou, D., Guo, L., Ji, Q., Chen, L., et al. (2019). Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev 35, e3158.
Kleinert, M., Clemmensen, C., Hofmann, S.M., Moore, M.C., Renner, S., Woods, S.C., Huypens, P., Beckers, J., de Angelis, M.H., Schürmann, A., et al. (2018). Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol 14, 140–162.
Nässel, D.R., Kubrak, O.I., Liu, Y., Luo, J., and Lushchak, O.V. (2013). Factors that regulate insulin producing cells and their output in Drosophila. Front Physiol 4, 252.
Neuenschwander, M., Ballon, A., Weber, K.S., Norat, T., Aune, D., Schwingshackl, L., and Schlesinger, S. (2019). Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies. BMJ 366, 12368.
Rulifson, E.J., Kim, S.K., and Nusse, R. (2002). Ablation of insulin-producing neurons in flies: Growth and diabetic phenotypes. Science 296, 1118–1120.
Thong, E.P., Codner, E., Laven, J.S.E., and Teede, H. (2020). Diabetes: a metabolic and reproductive disorder in women. Lancet Diabetes Endocrinol 8, 134–149.
Zheng, Y., Ley, S.H., and Hu, F.B. (2018). Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 14, 88–98.
Acknowledgements
This work was supported by the National Key Research and Development Program of China (2019YFA0802400, 2019YFA0801900) and the National Natural Science Foundation of China (31522026). We thank all Wang Lab members for helpful discussions and technical assistance. We thank the Bloomington Drosophila stock center at Indiana University and the Tsinghua Fly Center for fly stocks and reagents. We thank Jianhua Huang for help with the fecundity analysis. We thank Ran Li, Guo Cheng, and Tingting Song for help with RNAseq data analysis. We thank Neuroscience Pioneer Club for insightful discussions throughout the course of this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The author(s) declare that they have no conflict of interest.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Chen, D., Yang, J., Xiao, Z. et al. A diet-induced type 2 diabetes model in Drosophila. Sci. China Life Sci. 64, 326–329 (2021). https://doi.org/10.1007/s11427-020-1774-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-020-1774-y