Skip to main content
Log in

A diet-induced type 2 diabetes model in Drosophila

  • Letter to the Editor
  • Published:
Science China Life Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Baker, K.D., and Thummel, C.S. (2007). Diabetic larvae and obese flies—Emerging studies of metabolism in Drosophila. Cell Metab 6, 257–266.

    Article  CAS  Google Scholar 

  • Baribault, H. (2016). Mouse models of type 2 diabetes mellitus in drug discovery. In: Proetzel, G., Wiles, M.V., eds. Mouse Models for Drug Discovery. Methods in Molecular Biology. New York: Humana Press, 153–175.

    Chapter  Google Scholar 

  • Honegger, B., Galic, M., Köhler, K., Wittwer, F., Brogiolo, W., Hafen, E., and Stocker, H. (2008). Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J Biol 7, 10.

    Article  Google Scholar 

  • Jia, W., Weng, J., Zhu, D., Ji, L., Lu, J., Zhou, Z., Zou, D., Guo, L., Ji, Q., Chen, L., et al. (2019). Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev 35, e3158.

    Article  Google Scholar 

  • Kleinert, M., Clemmensen, C., Hofmann, S.M., Moore, M.C., Renner, S., Woods, S.C., Huypens, P., Beckers, J., de Angelis, M.H., Schürmann, A., et al. (2018). Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol 14, 140–162.

    Article  Google Scholar 

  • Nässel, D.R., Kubrak, O.I., Liu, Y., Luo, J., and Lushchak, O.V. (2013). Factors that regulate insulin producing cells and their output in Drosophila. Front Physiol 4, 252.

    Article  Google Scholar 

  • Neuenschwander, M., Ballon, A., Weber, K.S., Norat, T., Aune, D., Schwingshackl, L., and Schlesinger, S. (2019). Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies. BMJ 366, 12368.

    Google Scholar 

  • Rulifson, E.J., Kim, S.K., and Nusse, R. (2002). Ablation of insulin-producing neurons in flies: Growth and diabetic phenotypes. Science 296, 1118–1120.

    Article  CAS  Google Scholar 

  • Thong, E.P., Codner, E., Laven, J.S.E., and Teede, H. (2020). Diabetes: a metabolic and reproductive disorder in women. Lancet Diabetes Endocrinol 8, 134–149.

    Article  CAS  Google Scholar 

  • Zheng, Y., Ley, S.H., and Hu, F.B. (2018). Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 14, 88–98.

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Key Research and Development Program of China (2019YFA0802400, 2019YFA0801900) and the National Natural Science Foundation of China (31522026). We thank all Wang Lab members for helpful discussions and technical assistance. We thank the Bloomington Drosophila stock center at Indiana University and the Tsinghua Fly Center for fly stocks and reagents. We thank Jianhua Huang for help with the fecundity analysis. We thank Ran Li, Guo Cheng, and Tingting Song for help with RNAseq data analysis. We thank Neuroscience Pioneer Club for insightful discussions throughout the course of this study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Liming Wang.

Ethics declarations

The author(s) declare that they have no conflict of interest.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, D., Yang, J., Xiao, Z. et al. A diet-induced type 2 diabetes model in Drosophila. Sci. China Life Sci. 64, 326–329 (2021). https://doi.org/10.1007/s11427-020-1774-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11427-020-1774-y

Navigation