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Fish TNF and TNF receptors

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Abstract

Tumor necrosis factors (TNFs) are a group of cytokines that play critical roles in regulating a diverse range of physiological processes in vertebrates. TNFs function by activating a large number of structurally related receptors, leading to TNF mediated biological processes which are evolutionarily conserved. Fish have a much diversified TNF family, partly due to the whole genome duplication events which have occurred in this lineage, providing an excellent model to investigate the neo- and sub-functionalised properties of TNF superfamily. Fish possess most of the TNFs and receptors found in mammals and also some homologues exclusively present in fish. It seems that TNFSF4 (OX40), TNFSF7 (CD27) and TNFSF8 (CD30) and their cognate receptors are absent in teleosts. It has been shown that fish viruses are able to produce TNFR homologues to establish infection by manipulating the host immune system. Understanding the roles of TNFSFs in fish immune defence and the pathogenesis of fish diseases will provide insights into the functions of TNFSFs from an evolutionary perspective and better strategies for improving fish health and welfare in aquaculture. This review summarises recent advances in the study offish TNF biology and focuses on the molecular properties and immunological functions of the TNF and TNFR superfamily.

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Acknowledgements

This work is funded by the National Key R&D Program of China (2018YFD0900302), National Natural Science Foundation of China (31802288, 31572615), and China Postdoctoral Science Foundation (2017M612560, 2018T110833).

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Authors and Affiliations

  1. Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha, 410128, China

    Yaoguo Li, Tiaoyi Xiao & Jun Zou

  2. Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, China

    Jun Zou

  3. Ministry of Science and Technology, International Research Center for Marine Biosciences at Shanghai Ocean University, Shanghai, 201306, China

    Jun Zou

  4. Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China

    Jun Zou

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  1. Yaoguo Li
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Li, Y., Xiao, T. & Zou, J. Fish TNF and TNF receptors. Sci. China Life Sci. 64, 196–220 (2021). https://doi.org/10.1007/s11427-020-1712-4

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