Skip to main content
Log in

Enrichment of AT-TA transversion at 5′-CAG-3′ motif is not a unique mutational signature of aristolochic acid

  • Insight
  • Published:
Science China Life Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Bolt, H.M., Peter, H., and Föst, U. (1988). Analysis of macromolecular ethylene oxide adducts. Int Arch Occup Environ Health 60, 141–144.

    Article  CAS  PubMed  Google Scholar 

  • Connor, F., Rayner, T.F., Aitken, S.J., Feig, C., Lukk, M., Santoyo-Lopez, J., and Odom, D.T. (2018). Mutational landscape of a chemically-induced mouse model of liver cancer. J Hepatology 69, 840–850.

    Article  Google Scholar 

  • Fedeles, B.I., Singh, V., Delaney, J.C., Li, D., and Essigmann, J.M. (2015). The AlkB family of Fe(II)/α-ketoglutarate-dependent dioxygenases: repairing nucleic acid alkylation damage and beyond. J Biol Chem 290, 20734–20742.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garaycoechea, J.I., Crossan, G.P., Langevin, F., Mulderrig, L., Louzada, S., Yang, F., Guilbaud, G., Park, N., Roerink, S., Nik-Zainal, S., et al. (2018). Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature 553, 171–177.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grollman, A.P., Shibutani, S., Moriya, M., Miller, F., Wu, L., Moll, U., Suzuki, N., Fernandes, A., Rosenquist, T., Medverec, Z., et al. (2007). Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA 104, 12129–12134.

    Article  CAS  PubMed  Google Scholar 

  • Hawkins, W.E., Walker, W.W., Overstreet, R.M., Lytle, J.S., and Lytle, T.F. (1990). Carcinogenic effects of some polycyclic aromatic hydrocarbons on the Japanese medaka and guppy in waterborne exposures. Sci Total Environ 94, 155–167.

    Article  CAS  PubMed  Google Scholar 

  • Huang, M.N., Yu, W., Teoh, W.W., Ardin, M., Jusakul, A., Ng, A.W.T., Boot, A., Abedi-Ardekani, B., Villar, S., Myint, S.S., et al. (2017). Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. Genome Res 27, 1475–1486.

    Article  CAS  Google Scholar 

  • Kao, H.J., Cheng, C.F., Chen, Y.H., Hung, S.I., Huang, C.C., Millington, D., Kikuchi, T., Wu, J.Y., and Chen, Y.T. (2006). ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein β-subunit. Human Mol Genets 15, 3569–3577.

    Article  CAS  Google Scholar 

  • Liao, D.J., Blanck, A., Eneroth, P., Gustafsson, J.A., and Hällström, I.P. (2001). Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat. Environ Health Perspect 109, 943–947.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lv, G., Tan, Y., Lv, H., Fang, T., Wang, C., Li, T., Yu, Y., Hu, C., Wen, W., Wang, H., et al. (2017). MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition. Sci China Life Sci 60, 1203–1213.

    Article  CAS  PubMed  Google Scholar 

  • McCreery, M.Q., Halliwill, K.D., Chin, D., Delrosario, R., Hirst, G., Vuong, P., Jen, K.Y., Hewinson, J., Adams, D.J., and Balmain, A. (2015). Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. Nat Med 21, 1514–1520.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Minko, I.G., Rizzo, C.J., and Lloyd, R.S. (2017). Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer. J Biol Chem 292, 18790–18799.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mutlu, E., Jeong, Y.C., Collins, L.B., Ham, A.J.L., Upton, P.B., Hatch, G., Winsett, D., Evansky, P., and Swenberg, J.A. (2012). A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-Oxoethyl)guanine in sprague-dawley rats. Chem Res Toxicol 25, 391–399.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nassar, D., Latil, M., Boeckx, B., Lambrechts, D., and Blanpain, C. (2015). Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma. Nat Med 21, 946–954.

    Article  CAS  PubMed  Google Scholar 

  • Ng, A.W.T., Poon, S.L., Huang, M.N., Lim, J.Q., Boot, A., Yu, W., Suzuki, Y., Thangaraju, S., Ng, C.C.Y., Tan, P., et al. (2017). Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. Sci Transl Med 9, eaan6446.

    Article  CAS  PubMed  Google Scholar 

  • Sidorenko, V.S., Yeo, J.E., Bonala, R.R., Johnson, F., Schärer, O.D., and Grollman, A.P. (2012). Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts. Nucleic Acids Res 40, 2494–2505.

    Article  CAS  PubMed  Google Scholar 

  • Tong, S. (2005). Mechanism of HBV genome variability and replication of HBV mutants. J Clin Virol 34, S134–S138.

    Article  CAS  PubMed  Google Scholar 

  • Wu, K.Y., Chiang, S.Y., Shih, W.C., Huang, C.C.J., Chen, M.F., and Swenberg, J.A. (2011). The application of mass spectrometry in molecular dosimetry: ethylene oxide as an example. Mass Spectrom Rev 63, 733–756.

    Google Scholar 

  • Yu, L.X., Ling, Y., and Wang, H.Y. (2018). Role of nonresolving inflammation in hepatocellular carcinoma development and progression. NPJ Precis Oncol 2, 6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhu, J., Yu, H., Chen, S., Yang, P., Dong, Z., Ling, Y., Tang, H., Bai, S., Yang, W., Tang, L., et al. (2018). Prognostic significance of combining high mobility group Box-1 and OV-6 expression in hepatocellular carcinoma. Sci China Life Sci 61, 912–923.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by grants from the National Science and Technology Major Project (2018ZX09101002-002).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jin Ren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, X., Qi, X. & Ren, J. Enrichment of AT-TA transversion at 5′-CAG-3′ motif is not a unique mutational signature of aristolochic acid. Sci. China Life Sci. 62, 974–977 (2019). https://doi.org/10.1007/s11427-019-9566-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11427-019-9566-7

Navigation