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Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study

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Abstract

We conducted a retrospective cohort study of 9,552 women experiencing their second delivery between 2014 and 2016 at the International Peace Maternity and Child Health Hospital to investigate the association between the interpregnancy interval (IPI) and adverse perinatal outcomes. With the 12–23-mon IPI as the reference category, logistic regression analyzes were used to examine associations between different IPIs (<12, 12–23, 24–59, 60–119, and ≥120 mon) and perinatal outcomes (gestational diabetes mellitus, premature membrane rupture, gestational hypertension, preterm birth, low birth weight, and macrosomia). Compared with the 12–23-mon IPI category, women with longer IPIs had a higher risk of adverse perinatal outcomes, and those with an IPI ≥120 mon had the highest risk of gestational diabetes mellitus and premature membrane rupture (adjusted odds ratio (OR) 1.76, 95% confidence interval (CI) 1.32–2.35 and adjusted OR 2.03, 95% CI 1.53–2.67, respectively). These results indicate that a longer IPI is associated with a higher risk of adverse perinatal outcomes and an IPI of ≥120 mon appears to be independently associated with a higher risk of gestational diabetes mellitus and premature membrane rupture.

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Acknowledgements

This work was supported by the Major Program of National Natural Science Foundation of China (81490742, 31471405, 81771593 and 81671456), the National Key Research and Development Program of China (2017YFC1001303 and 2018YFC1003200), the International Cooperation Project of China and Canada NSFC (81661128010), the Interdisciplinary Key Program of Shanghai Jiao Tong University (YG2014ZD08), and the Shen Kang Three-Year Action Plan (16CR3003A).

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  1. Contributed equally to this work.

Authors and Affiliations

  1. International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China

    Jing Lin, Han Liu, Dan-Dan Wu, Hong-Tao Hu, Hui-Hui Wang, Cheng-Liang Zhou, Xin-Mei Liu, Xiao-Jun Chen & He-Feng Huang

  2. Institute of Embryo-Fetal Original Adult Disease, Shanghai Key Laboratory for Reproductive Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China

    Jing Lin, Han Liu, Dan-Dan Wu, Hong-Tao Hu, Hui-Hui Wang, Cheng-Liang Zhou, Xin-Mei Liu & He-Feng Huang

  3. Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China

    Jing Lin, Han Liu, Dan-Dan Wu, Hong-Tao Hu, Hui-Hui Wang, Cheng-Liang Zhou, Xin-Mei Liu & He-Feng Huang

  4. Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, 310058, China

    Jian-Zhong Sheng

Authors
  1. Jing Lin
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  2. Han Liu
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  3. Dan-Dan Wu
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  9. Jian-Zhong Sheng
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  10. He-Feng Huang
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Corresponding author

Correspondence to He-Feng Huang.

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Compliance and ethics The author(s) declare that they have no conflict of interest. The study was approved by the Ethics Committee of the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University. Written informed consent was obtained from all participants.

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Lin, J., Liu, H., Wu, DD. et al. Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study. Sci. China Life Sci. 63, 898–904 (2020). https://doi.org/10.1007/s11427-018-9593-8

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  • DOI: https://doi.org/10.1007/s11427-018-9593-8

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