Skip to main content
Log in

Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity

  • Letter to the Editor
  • Published:
Science China Life Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Frank-Kamenetsky, M., Zhang, X.M., Bottega, S., Guicherit, O., Wichterle, H., Dudek, H., Bumcrot, D., Wang, F.Y., Jones, S., Shulok, J., et al. (2002). Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol 1, 10.

    Article  Google Scholar 

  • Fuss, J.O., and Tainer, J.A. (2011). XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase. DNA Repair 10, 697–713.

    Article  CAS  Google Scholar 

  • Hidalgo, M. (2010). Pancreatic cancer. N Engl J Med 362, 1605–1617.

    Article  CAS  Google Scholar 

  • Junker, J.P., Peterson, K.A., Nishi, Y., Mao, J., McMahon, A.P., and van Oudenaarden, A. (2014). A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning. Dev Cell 31, 448–460.

    Article  CAS  Google Scholar 

  • Liu, Y., and Cui, Y.F. (2013). Synergism of cytotoxicity effects of triptolide and artesunate combination treatment in pancreatic cancer cell lines. Asian Pac J Cancer Prevent 14, 5243–5248.

    Article  Google Scholar 

  • Thayer, S.P., di Magliano, M.P., Heiser, P.W., Nielsen, C.M., Roberts, D.J., Lauwers, G.Y., Qi, Y.P., Gysin, S., Fernández-del Castillo, C., Yajnik, V., et al. (2003). Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425, 851–856.

    Article  CAS  Google Scholar 

  • Wu, V.M., Chen, S.C., Arkin, M.R., and Reiter, J.F. (2012). Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proc Natl Acad Sci USA 109, 13644–13649.

    Article  CAS  Google Scholar 

  • Zhou, Z.L., Yang, Y.X., Ding, J., Li, Y.C., and Miao, Z.H. (2012). Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep 29, 457–475.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (81872418), Shanghai Natural Science Foundation (18ZR1431700), Shanghai Municipal Health and Family Planning Commission Project (201540027, 20174Y0236, and 20184Y0104), the Seed Fund Program of Shanghai University of Medicine & Health Sciences (HSMF-17-22-031, SFP-18-21-15-003, and SPF-18-20-15-001), the Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ048), and Shanghai Fengxian District Science and Technology Project (20181601).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zhenliang Sun.

Ethics declarations

Compliance and ethics The author(s) declare that they have no conflict of interest. All animal experiments were administered according to the guidelines of the Institutional Animal Care and Use Committee and all the protocols were approved by the East China Normal University (Shanghai, China).

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Feng, J., Rao, M., Wang, M. et al. Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity. Sci. China Life Sci. 62, 1409–1412 (2019). https://doi.org/10.1007/s11427-018-9477-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11427-018-9477-3

Navigation