References
Frank-Kamenetsky, M., Zhang, X.M., Bottega, S., Guicherit, O., Wichterle, H., Dudek, H., Bumcrot, D., Wang, F.Y., Jones, S., Shulok, J., et al. (2002). Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol 1, 10.
Fuss, J.O., and Tainer, J.A. (2011). XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase. DNA Repair 10, 697–713.
Hidalgo, M. (2010). Pancreatic cancer. N Engl J Med 362, 1605–1617.
Junker, J.P., Peterson, K.A., Nishi, Y., Mao, J., McMahon, A.P., and van Oudenaarden, A. (2014). A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning. Dev Cell 31, 448–460.
Liu, Y., and Cui, Y.F. (2013). Synergism of cytotoxicity effects of triptolide and artesunate combination treatment in pancreatic cancer cell lines. Asian Pac J Cancer Prevent 14, 5243–5248.
Thayer, S.P., di Magliano, M.P., Heiser, P.W., Nielsen, C.M., Roberts, D.J., Lauwers, G.Y., Qi, Y.P., Gysin, S., Fernández-del Castillo, C., Yajnik, V., et al. (2003). Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425, 851–856.
Wu, V.M., Chen, S.C., Arkin, M.R., and Reiter, J.F. (2012). Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proc Natl Acad Sci USA 109, 13644–13649.
Zhou, Z.L., Yang, Y.X., Ding, J., Li, Y.C., and Miao, Z.H. (2012). Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep 29, 457–475.
Acknowledgements
This work was supported by the National Natural Science Foundation of China (81872418), Shanghai Natural Science Foundation (18ZR1431700), Shanghai Municipal Health and Family Planning Commission Project (201540027, 20174Y0236, and 20184Y0104), the Seed Fund Program of Shanghai University of Medicine & Health Sciences (HSMF-17-22-031, SFP-18-21-15-003, and SPF-18-20-15-001), the Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ048), and Shanghai Fengxian District Science and Technology Project (20181601).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Compliance and ethics The author(s) declare that they have no conflict of interest. All animal experiments were administered according to the guidelines of the Institutional Animal Care and Use Committee and all the protocols were approved by the East China Normal University (Shanghai, China).
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Feng, J., Rao, M., Wang, M. et al. Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity. Sci. China Life Sci. 62, 1409–1412 (2019). https://doi.org/10.1007/s11427-018-9477-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-018-9477-3