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Analysis of status and countermeasures of cancer incidence and mortality in China

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Abstract

Cancer is the leading cause of human deaths in the world and produces serious economic burdens. On September 12, 2018, the academic journal A Cancer Journal for Clinicians published an article about the latest statistics of cancers worldwide, which provided a status report on the global burden of 36 cancers in 185 countries worldwide. Cancer has also become a serious public health problem in China and caused more and more attention of the government and people in recent years. This review analyzes the incidence, mortality and prevalent trend of cancers in China, discusses the reasons behind this status, and reviews the potential countermeasures for cancer prevention and control in China.

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References

  • Abderrahman, B., and Jordan, V.C. (2018). Successful targeted therapies for breast cancer: the Worcester Foundation and future opportunities in women’s health. Endocrinology 159, 2980–2990.

    Article  PubMed  Google Scholar 

  • Allemani, C., Matsuda, T., Di Carlo, V., Harewood, R., Matz, M., Nikšić, M., Bonaventure, A., Valkov, M., Johnson, C.J., Estève, J., et al. (2018). Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet 391, 1023–1075.

    Article  PubMed  PubMed Central  Google Scholar 

  • Boér, K. (2016). Impact of palbociclib combinations on treatment of advanced estrogen receptor-positive/human epidermal growth factor 2-negative breast cancer. Onco Targets Ther 9, 6119–6125.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., and Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 1–31.

    Google Scholar 

  • Brufsky, A.M., and Dickler, M.N. (2018). Estrogen receptor-positive breast cancer: Exploiting signaling pathways implicated in endocrine resistance. Oncologist 23, 528–539.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cao, Z.F., Chen, W.C., Yang, P.P., Zhou, H.M., and Ou, W.B. (2017). Advances of succinate dehydrogenase mutation in cancers. Prog Biochem Biophys 44, 31–43.

    Google Scholar 

  • Chen, C., Sun, S., Yuan, J.P., Wang, Y.H., Cao, T.Z., Zheng, H.M., Jiang, X. Q., Gong, Y.P., Tu, Y., Yao, F., et al. (2016). Characteristics of breast cancer in Central China, literature review and comparison with USA. Breast 30, 208–213.

    Article  PubMed  Google Scholar 

  • Chen, W., Sun, K., Zheng, R., Zeng, H., Zhang, S., Xia, C., Yang, Z., Li, H., Zou, X., and He, J. (2018). Cancer incidence and mortality in China, 2014. Chin J Cancer Res 30, 1–12.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen, W., Zheng, R., Baade, P.D., Zhang, S., Zeng, H., Bray, F., Jemal, A., Yu, X.Q., and He, J. (2016). Cancer statistics in China, 2015. CA Cancer J Clin 66, 115–132.

    Article  PubMed  Google Scholar 

  • Chen, W., Zheng, R., Zeng, H., and Zhang, S. (2014). Trend analysis of the changes of male/female, urban/rural incidences and average age of cancer patients in China 1989–2008 (in Chinese). Zhonghua Zhong Liu Za Zhi 36, 796–800.

    PubMed  Google Scholar 

  • Chen, S., Zhu, J.H., Wang, F., Huang, S.Y., Xue, W.Q., Cui, Z., He, J., and Jia, W.H. (2015). Association of the Asp312Asn and Lys751Gln polymorphisms in the XPD gene with the risk of non-Hodgkin’s lymphoma: evidence from a meta-analysis. Chin J Cancer 34, 2–12.

    Article  CAS  PubMed Central  Google Scholar 

  • Chen, W., Zheng, R., Zhang, S., Zeng, H., Xia, C., Zuo, T., Yang, Z., Zou, X., and He, J. (2017). Cancer incidence and mortality in China, 2013. Cancer Lett 401, 63–71.

    Article  CAS  PubMed  Google Scholar 

  • Chen, W., Zheng, R., Zhang, S., Zhao, P., Zeng, H., Zou, X., and He, J. (2014). Annual report on status of cancer in China, 2010. Chin J Cancer Res 26, 48–58.

    PubMed  PubMed Central  Google Scholar 

  • Chen, X., Ye, G., Zhang, C., Li, X., and Shen, K. (2016). Nonanthracycline-containing docetaxel and cyclophosphamide regimen is associated with sustained worse outcome compared with docetaxel, anthracycline and cyclophosphamide in neoadjuvant treatment of triple negative and HER2-positive breast cancer patients: updated follow-up data from NATT study. Chin J Cancer Res 28, 561–569.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen, W.Q. (2016). Discussion on the clinical characteristics and trends of cancers in China according to cancer registry (in Chinese). Chin J Health Manage 10, 249–252.

    Google Scholar 

  • Chen, W.Q., Sun, K.X., and Zheng, R.S. (2018). Report of cancer incidence and mortality in different areas of China, 2014. China Cancer.

    Google Scholar 

  • Chen, W.Q., Zheng, R.S., Zeng, H.M., Zhang, S.W., Zhao, P., and He, J. (2012). Trend analysis and projection of cancer incidence in China between 1989 and 2008 (in Chinese). Zhonghua Zhong Liu Za Zhi 34, 517–524.

    PubMed  Google Scholar 

  • Coleman, M., Forman, D., Bryant, H., Butler, J., Rachet, B., Maringe, C., Nur, U., Tracey, E., Coory, M., Hatcher, J., et al. (2011). Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995–2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data. Lancet 377, 127–138.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cronin, K.A., Lake, A.J., Scott, S., Sherman, R.L., Noone, A.M., Howlader, N., Henley, S.J., Anderson, R.N., Firth, A.U., Ma, J., et al. (2018). Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics. Cancer 124, 2785–2800.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dong, H., Duan, S., Bogg, L., Wu, Y., You, H., Chen, J., Ye, X., Seccombe, K., and Yu, H. (2016). The impact of expanded health system reform on governmental contributions and individual copayments in the new Chinese rural cooperative medical system. Int J Health Plann Manage 31, 36–48.

    Article  PubMed  Google Scholar 

  • Dwyer-Lindgren, L., Mokdad, A.H., Srebotnjak, T., Flaxman, A.D., Hansen, G.M., and Murray, C.J. (2014). Cigarette smoking prevalence in US counties: 1996–2012. Popul Health Metrics 12, 5.

    Article  Google Scholar 

  • Fan, C., Tang, Y., Wang, J., Wang, Y., Xiong, F., Zhang, S., Li, X., Xiang, B., Wu, X., Guo, C., et al. (2018). Long non-coding RNA LOC284454 promotes migration and invasion of nasopharyngeal carcinoma via modulating the Rho/Rac signaling pathway. Carcinogenesis 91.

    Google Scholar 

  • Fan, L., Strasser-Weippl, K., Li, J.J., St Louis, J., Finkelstein, D.M., Yu, K. D., Chen, W.Q., Shao, Z.M., and Goss, P.E. (2014). Breast cancer in China. Lancet Oncol 15, e279–e289.

    Article  Google Scholar 

  • Goss, P.E., Strasser-Weippl, K., Lee-Bychkovsky, B.L., Fan, L., Li, J., Chavarri-Guerra, Y., Liedke, P.E.R., Pramesh, C.S., Badovinac-Crnjevic, T., Sheikine, Y., et al. (2014). Challenges to effective cancer control in China, India, and Russia. Lancet Oncol 15, 489–538.

    Article  PubMed  Google Scholar 

  • He, Y.T., Zheng, R.S., and Sun, X.B. (2013). The difference of cancer incidence between male and female in China. China Cancer 22.

    Google Scholar 

  • Islami, F., Goding Sauer, A., Miller, K.D., Siegel, R.L., Fedewa, S.A., Jacobs, E.J., McCullough, M.L., Patel, A.V., Ma, J., Soerjomataram, I., et al. (2018). Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin 68, 31–54.

    Article  Google Scholar 

  • Ju, J., Zhu, A.J., and Yuan, P. (2018). Progress in targeted therapy for breast cancer. Chronic Dis Transl Med 4, 164–175.

    Article  PubMed  PubMed Central  Google Scholar 

  • Katoh, H., Wang, D., Daikoku, T., Sun, H., Dey, S.K., and Dubois, R.N. (2013). CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell 24, 631–644.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Klages-Mundt, N.L., and Li, L. (2017). Formation and repair of DNAprotein crosslink damage. Sci China Life Sci 60, 1065–1076.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Levine, A.S., Sun, L., Tan, R., Gao, Y., Yang, L., Chen, H., Teng, Y., and Lan, L. (2017). The oxidative DNA damage response: A review of research undertaken with Tsinghua and Xiangya students at the University of Pittsburgh. Sci China Life Sci 60, 1077–1080.

    Article  CAS  PubMed  Google Scholar 

  • Li, S., Bao, X., Wang, D., You, L., Li, X., Yang, H., Bian, J., Wang, Y., and Yang, Y. (2017). APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells. Sci China Life Sci 60, 617–626.

    Article  CAS  PubMed  Google Scholar 

  • Lian, Y., Xiong, F., Yang, L., Bo, H., Gong, Z., Wang, Y., Wei, F., Tang, Y., Li, X., Liao, Q., et al. (2018). Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway. J Exp Clin Cancer Res 37, 253.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu, X., Wong, H., and Liu, K. (2015). Outcome-based health equity across different social health insurance schemes for the elderly in China. BMC Health Serv Res 16, 9.

    Article  Google Scholar 

  • Liu, Y., Zhao, R., Wang, H., Luo, Y., Wang, X., Niu, W., Zhou, Y., Wen, Q., Fan, S., Li, X., et al. (2016). miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma. Cell Death Dis 7, e2156.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu, Y., Zhao, R., Wei, Y., Li, M., Wang, H., Niu, W., Zhou, Y., Qiu, Y., Fan, S., Zhan, Y., et al. (2018). BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141. J Exp Clin Cancer Res 37, 64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lu, Y.F., Liu, Z.C., Li, Z.H., Ma, W.H., Wang, F.R., Zhang, Y.B., and Lu, J. B. (2014). Esophageal/gastric cancer screening in high-risk populations in Henan Province, China. Asian Pac J Cancer Prev 15, 1419–1422.

    Article  PubMed  Google Scholar 

  • Niu, W., Luo, Y., Wang, X., Zhou, Y., Li, H., Wang, H., Fu, Y., Liu, S., Yin, S., Li, J., et al. (2018). BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer. Cell Death Dis 9, 519.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rugo, H.S., Olopade, O.I., DeMichele, A., Yau, C., van 't Veer, L.J., Buxton, M.B., Hogarth, M., Hylton, N.M., Paoloni, M., Perlmutter, J., et al. (2016). Adaptive randomization of Veliparib-Carboplatin treatment in breast cancer. N Engl J Med 375, 23–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanmamed, M.F., and Chen, L. (2018). A paradigm shift in cancer immunotherapy: from enhancement to normalization. Cell 175, 313–326.

    Article  CAS  PubMed  Google Scholar 

  • Shi, Q., and Chen, Y.G. (2017). Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development. Sci China Life Sci 60, 1133–1141.

    Article  CAS  PubMed  Google Scholar 

  • Siegel, R.L., Miller, K.D., and Jemal, A. (2018). Cancer statistics, 2018. CA Cancer J Clin 68, 7–30.

    Article  Google Scholar 

  • Stagg, J., Loi, S., Divisekera, U., Foong Ngiow, S., Duret, H., Yagita, H., Teng, M.W., and Smyth, M.J. (2011). Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy. Proc Natl Acad Sci USA 108, 7142–7147.

    Article  CAS  PubMed  Google Scholar 

  • Tryfonidis, K., Zardavas, D., Katzenellenbogen, B.S., and Piccart, M. (2016). Endocrine treatment in breast cancer: Cure, resistance and beyond. Cancer Treat Rev 50, 68–81.

    Article  PubMed  Google Scholar 

  • Wang, K., Ren, Y., Li, H., Zheng, K., Jiang, J., Zou, T., Ma, B., Li, H., Liu, Q., Ou, J., et al. (2016). Comparison of clinicopathological features and treatments between young (≤40 Years) and older (>40 Years) female breast cancer patients in West China: A retrospective, epidemiological, multicenter, case only study. PLoS ONE 11, e0152312.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang, Y.A., Li, X.L., Mo, Y.Z., Fan, C.M., Tang, L., Xiong, F., Guo, C., Xiang, B., Zhou, M., Ma, J., et al. (2018). Effects of tumor metabolic microenvironment on regulatory T cells. Mol Cancer 17, 168.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wei, W.Q., Chen, Z.F., He, Y.T., Feng, H., Hou, J., Lin, D.M., Li, X.Q., Guo, C.L., Li, S.S., Wang, G.Q., et al. (2015). Long-term follow-up of a community assignment, one-time endoscopic screening study of esophageal cancer in China. J Clin Oncol 33, 1951–1957.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wilson, L.F., Antonsson, A., Green, A.C., Jordan, S.J., Kendall, B.J., Nagle, C.M., Neale, R.E., Olsen, C.M., Webb, P.M., and Whiteman, D. C. (2018). How many cancer cases and deaths are potentially preventable? Estimates for Australia in 2013. Int J Cancer 142, 691–701.

    Article  CAS  PubMed  Google Scholar 

  • Xie, Z., Liu, H., and Geng, M. (2017). Targeting sphingosine-1-phosphate signaling for cancer therapy. Sci China Life Sci 60, 585–600.

    Article  CAS  PubMed  Google Scholar 

  • Xu, D.H., Cui, Q.J., Xu, Y.J., Liu, D.X., and Kong, G.Y. (2017). Plasma medicine and the application in tumor therapy (in Chinese). Prog Biochem Biophys 44, 279–292.

    Google Scholar 

  • Yang, B.W., Chen, Y., and Shi, J.L. (2018). Nanozymes in catalytic cancer theranostics (in Chinese). Prog Biochem Biophys 45, 237–255.

    Google Scholar 

  • Yang, G., Wang, Y., Zeng, Y., Gao, G.F., Liang, X., Zhou, M., Wan, X., Yu, S., Jiang, Y., Naghavi, M., et al. (2013). Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010. Lancet 381, 1987–2015.

    Article  PubMed  Google Scholar 

  • Yang, R., and Hung, M.C. (2017). The role of T-cell immunoglobulin mucin-3 and its ligand galectin-9 in antitumor immunity and cancer immunotherapy. Sci China Life Sci 60, 1058–1064.

    Article  CAS  PubMed  Google Scholar 

  • Yuan, F.W., and Tong, T.J. (2018). Cellular senescence and tumor therapy (in Chinese). Prog Biochem Biophys 45, 494–500.

    Google Scholar 

  • Zeng, H., Chen, W., Zheng, R., Zhang, S., Ji, J.S., Zou, X., Xia, C., Sun, K., Yang, Z., Li, H., et al. (2018). Changing cancer survival in China during 2003–2015: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health 6, e555–e567.

    Article  PubMed  Google Scholar 

  • Zeng, H., Zheng, R., Guo, Y., Zhang, S., Zou, X., Wang, N., Zhang, L., Tang, J., Chen, J., Wei, K., et al. (2015). Cancer survival in China, 2003–2005: a population-based study. Int J Cancer 136, 1921–1930.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, B.H., Fei, X., Ren, H.J., and Bo, L. (2017). Regulation of HSP27 on cell migration (in Chinese). Prog Biochem Biophys 44, 110–116.

    CAS  Google Scholar 

  • Zhao, Q.F., Chen, S.J., Xiao, B.X., and Guo, J.M. (2018). The biological functions of circular RNAs and their roles in the occurrence of gastrointestinal tumors (in Chinese). Prog Biochem Biophys 45, 601–612.

    Google Scholar 

  • Zhao, R., Liu, Y., Wang, H., Yang, J., Niu, W., Fan, S., Xiong, W., Ma, J., Li, X., Phillips, J.B., et al. (2017). BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NFkB signaling pathway. Cell Mol Immunol 14, 830–841.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, M., Wang, H., Zhu, J., Chen, W., Wang, L., Liu, S., Li, Y., Wang, L., Liu, Y., Yin, P., et al. (2016). Cause-specific mortality for 240 causes in China during 1990–2013: a systematic subnational analysis for the Global Burden of Disease Study 2013. Lancet 387, 251–272.

    Article  PubMed  Google Scholar 

  • Zhou, Q.H., Fan, Y.G., Bu, H., Wang, Y., Wu, N., Huang, Y.C., Wang, G., Wang, X.Y., and Qiao, Y.L. (2015). China national lung cancer screening guideline with low-dose computed tomography (2015 version). Thoracic Cancer 6, 812–818.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhou, X., and Jiang, Z. (2017). STING-mediated DNA sensing in cancer immunotherapy. Sci China Life Sci 60, 563–574.

    Article  CAS  PubMed  Google Scholar 

  • Zou, X.N. (2017). Epidemic trend, screening, and early detection and treatment of cancer in Chinese population. Cancer Biol Med 14, 50–59.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by the grants from the National Natural Science Foundation of China (81772990 and 81572748) and the “111” Project (111-2-12).

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Correspondence to Ming Zhou.

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Wu, C., Li, M., Meng, H. et al. Analysis of status and countermeasures of cancer incidence and mortality in China. Sci. China Life Sci. 62, 640–647 (2019). https://doi.org/10.1007/s11427-018-9461-5

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