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Structural and functional insights into MCR-2 mediated colistin resistance

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Acknowledgements

We are grateful to Dr Gary Wong, Hao Song, Shuguang Tan and Lifeng Fu for helping prepare the figures and revise the manuscript. This work was supported by the Chinese Academy of Sciences (CAS) Strategic Priority Research Program (XDB08020100), the External Cooperation Program of Chinese Academy of Sciences (153211KYSB20160001) and the National Key Plan for Scientific Research and Development of China (2016YFD0500305). George Fu Gao is a leading principal investigator of the National Natural Science Foundation of China (NSFC) Innovative Research Group (81621091). The atomic coordinates and structure factors have been deposited in the Protein Data Bank with PDB ID code 6A7W. X-ray data were collected at beam line 17U of the Shanghai Synchrotron Radiation Facility (SSRF).

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  1. Contributed equally to this work

Authors and Affiliations

  1. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China

    Xudong Wang, Qiong Lu, Jianxun Qi, Yan Chai & George Fu Gao

  2. College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China

    Xudong Wang & George Fu Gao

  3. Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, Division of HIV/AIDS and Sexually Transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, 100050, China

    Qiong Lu & Youchun Wang

  4. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China

    George Fu Gao

  5. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China

    George Fu Gao

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  1. Xudong Wang
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  2. Qiong Lu
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Correspondence to George Fu Gao.

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Wang, X., Lu, Q., Qi, J. et al. Structural and functional insights into MCR-2 mediated colistin resistance. Sci. China Life Sci. 61, 1432–1436 (2018). https://doi.org/10.1007/s11427-018-9363-4

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