Science China Life Sciences

, Volume 61, Issue 5, pp 504–514 | Cite as

Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults: the China-PAR project

  • Chao Han
  • Fangchao Liu
  • Xueli Yang
  • Jichun Chen
  • Jianxin Li
  • Jie Cao
  • Ying Li
  • Chong Shen
  • Ling Yu
  • Zhendong Liu
  • Xianping Wu
  • Liancheng Zhao
  • Dongshen Hu
  • Xiangfeng Lu
  • Xigui Wu
  • Dongfeng Gu
Cover Article From CAS & CAE Members
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Abstract

Existing evidence on the relationship between cardiovascular health (CVH) metrics and cardiovascular disease (CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD (ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project (Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease (CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage (PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs (95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83 (0.74–0.93), 0.66 (0.59–0.74), 0.55 (0.48–0.61), 0.44 (0.38–0.50) and 0.24 (0.18–0.31), respectively (P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure (BP) implied the largest public health gains against various ASCVD events (PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD.

Keywords

cardiovascular health ASCVD cohort China 

Notes

Acknowledgements

The authors thank the staffs and participants of the China-PAR project for their important participation and contribution. This work was supported by grants from the CAMS Innovation Fund for Medical Sciences (2017-12M-1-004), Ministry of Science and Technology of China (2017YFC0211700), and National Natural Science Foundation of China (91643208).

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Chao Han
    • 1
  • Fangchao Liu
    • 1
  • Xueli Yang
    • 1
  • Jichun Chen
    • 1
  • Jianxin Li
    • 1
  • Jie Cao
    • 1
  • Ying Li
    • 1
  • Chong Shen
    • 2
  • Ling Yu
    • 3
  • Zhendong Liu
    • 4
  • Xianping Wu
    • 5
  • Liancheng Zhao
    • 1
  • Dongshen Hu
    • 6
  • Xiangfeng Lu
    • 1
  • Xigui Wu
    • 1
  • Dongfeng Gu
    • 1
  1. 1.Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Department of Epidemiology and Biostatistics, School of Public HealthNanjing Medical UniversityNanjingChina
  3. 3.Department of CardiologyFujian Provincial People’s HospitalFuzhouChina
  4. 4.Cardio-Cerebrovascular Control and Research Center, Institute of Basic MedicineShandong Academy of Medical SciencesJinanChina
  5. 5.Sichuan Center for Disease Control and PreventionChengduChina
  6. 6.Department of Prevention MedicineShenzhen University School of MedicineShenzhenChina

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