Large-area gold nanohole arrays fabricated by one-step method for surface plasmon resonance biochemical sensing
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Surface plasmon resonance (SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale arrays is essential for the development of SPR nanosensors. In this work, we report a one-step method to fabricate nanohole arrays by thermal nanoimprinting in the matrix of IPS (Intermediate Polymer Stamp). No additional etching process or supporting substrate is required. The preparation process is simple, time-saving and compatible for roll-to-roll process, potentially allowing mass production. Moreover, the nanohole arrays were integrated into detection platform as SPR sensors to investigate different types of biological binding interactions. The results demonstrate that our one-step method can be used to efficiently fabricate large-area and uniform nanohole arrays for biochemical sensing.
Keywordsgold nanohole arrays one-step method nanoimprinting nanosensor biomolecular binding
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This work was financially supported by the National Natural Science Foundation of China (31430061, 61401149, and U1604177), Ministry of Agriculture of China (2016ZX08009-003) and the Program of China’s 1000-talents Plan.
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