Science China Life Sciences

, Volume 61, Issue 8, pp 978–981 | Cite as

Developmental engineering: design of clinically efficacious bioartificial tissues through developmental and systems biology

  • Petros LenasEmail author
  • Laertis Ikonomou


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This work was supported by the National Institute of Health (NIH) grants (R01 HL111574, R01 HL124280 to Laertis Ikonomou).


  1. Aristotle. (1924). Metaphysics. (Oxford: Clarendon Press). Translated by Ross WD.Google Scholar
  2. Bolker, J.A. (2000). Modularity in development and why it matters in Evo-Devo. Amer Zool 40, 770–776.Google Scholar
  3. Chuang Tzu. (1968). The Complete Works of Chuang Tzu. (New York: Columbia University Press). Translated by Burton W.Google Scholar
  4. Clevers, H. (2016). Modeling development and disease with organoids. Cell 165, 1586–1597.CrossRefPubMedGoogle Scholar
  5. Editorial. (1999). Complicated is not complex. Nat Biotechnol 17, 511.Google Scholar
  6. Editorial. (2005). In pursuit of systems. Nature 435, 1.Google Scholar
  7. Fung, Y.C., and Tong, P. (2001). Classical and computational solid mechanics. In: Advanced Series in Engineering Science (Singapore: World Scientific).CrossRefGoogle Scholar
  8. Jungermann, K., and Sasse, D. (1978). Heterogeneity of liver parenchymal cells. Trends Biochem Sci 3, 198–202.CrossRefGoogle Scholar
  9. Kaplan, D.L., Moon, R.T., and Vunjak-Novakovic, G. (2005). It takes a village to grow a tissue. Nat Biotechnol 23, 1237–1239.CrossRefPubMedGoogle Scholar
  10. Lao Tzu. (1963). Tao Te Ching. (Harmondsworth: Penguin Books). Translated by Lau DC.Google Scholar
  11. Lenas, P., Moos, M., and Luyten, F.P. (2009a). Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part I: from three-dimensional cell growth to biomimetics of in vivo development. Tissue Eng Part B Rev 15, 381–394.CrossRefPubMedGoogle Scholar
  12. Lenas, P., Moos, M., and Luyten, F.P. (2009b). Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part II: from genes to networks: tissue engineering from the viewpoint of systems biology and network science. Tissue Eng Part B Rev 15, 395–422.PubMedGoogle Scholar
  13. Martin, I. (2014). Engineered tissues as customized organ germs. Tissue Eng Part A 20, 1132–1133.CrossRefPubMedGoogle Scholar
  14. Scotti, C., Piccinini, E., Takizawa, H., Todorov, A., Bourgine, P., Papadimitropoulos, A., Barbero, A., Manz, M.G., and Martin, I. (2013). Engineering of a functional bone organ through endochondral ossification. Proc Natl Acad Sci USA 110, 3997–4002.CrossRefPubMedGoogle Scholar
  15. Viola, J., Lal, B., and Grad, O. (2003). The Emergence of Tissue Engineering as a Research Field. (National Science Foundation). Scholar
  16. Vacanti, J.P., Morse, M.A., Saltzman, W.M., Domb, A.J., Perez-Atayde, A., and Langer, R. (1988). Selective cell transplantation using bioabsorbable artificial polymers as matrices. J Pediatr Surg 23, 3–9.CrossRefPubMedGoogle Scholar
  17. von Dassow, G., Meir, E., Munro, E.M., and Odell, G.M. (2000). The segment polarity network is a robust developmental module. Nature 406, 188–192.CrossRefGoogle Scholar
  18. Zheng, H., Hutchins, A.P., Pan, G., Li, Y., Pei, D., and Pei, G. (2014). Where cell fate conversions meet Chinese philosophy. Cell Res 24, 1162–1163.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of ScienceHarbin Institute of Technology ShenzhenShenzhenChina
  2. 2.Center for Regenerative Medicine of Boston University and Boston Medical CenterBostonUSA

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