References
Cai, B., Guo, M., Wang, Y., Zhang, Y., Yang, J., Guo, Y., Dai, H., Yu, C., Sun, Q., Qiao, J., Hu, K., Zuo, H., Dong, Z., Zhang, Z., Feng, M., Li, B., Sun, Y., Liu, T., Liu, Z., Wang, Y., Huang, Y., Yao, B., Han, W., and Ai, H. (2016). Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia. J Hematol Oncol 9, 131.
Dai, H., Wang, Y. Lu, X., and Han, W. (2016). Chimeric antigen receptors modified T-cells for cancer therapy. J Natl Cancer Inst 108, pii: djv439.
Eyquem, J., Mansilla-Soto, J., Giavridis, T., van der Stegen, S.J.C., Hamieh, M., Cunanan, K.M., Odak, A., Gönen, M., and Sadelain, M. (2017). Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature 543, 113–117.
Fedorov, V.D., Themeli, M., and Sadelain, M. (2013). PD-1-and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. Sci Transl Med 5, 215ra172–215ra172.
Feng, K., Guo, Y., Dai, H., Wang, Y., Li, X., Jia, H., and Han, W. (2016). Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer. Sci China Life Sci 59, 468–479.
Gilham, D.E., Debets, R., Pule, M., Hawkins, R.E., and Abken, H. (2012). CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe. Trends Mol Med 18, 377–384.
Grupp, S.A., Kalos, M., Barrett, D., Aplenc, R., Porter, D.L., Rheingold, S.R., Teachey, D.T., Chew, A., Hauck, B., Wright, J.F., Milone, M.C., Levine, B.L., and June, C.H. (2013). Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 368, 1509–1518.
Hartmann, J., Schüßler-Lenz, M., Bondanza, A., and Buchholz, C.J. (2017). Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts. EMBO Mol Med 9, 1183–1197.
Luo, C., Wei, J., and Han, W. (2016). Spotlight on chimeric antigen receptor engineered T cell research and clinical trials in China. Sci China Life Sci 59, 349–359.
Maude, S.L., Frey, N., Shaw, P.A., Aplenc, R., Barrett, D.M., Bunin, N.J., Chew, A., Gonzalez, V.E., Zheng, Z., Lacey, S.F., Mahnke, Y.D., Melenhorst, J.J., Rheingold, S.R., Shen, A., Teachey, D.T., Levine, B.L., June, C.H., Porter, D.L., and Grupp, S.A. (2014). Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 371, 1507–1517.
Sadelain, M. (2016). Chimeric antigen receptors: driving immunology towards synthetic biology. Curr Opin Immunol 41, 68–76.
Sell, S. (2017). Cancer immunotherapy: Breakthrough or “deja vu, all over again”? Tumour Biol 39, 101042831770776.
Wang, X., Popplewell, L.L., Wagner, J.R., Naranjo, A., Blanchard, M.S., Mott, M.R., Norris, A.P., Wong, C.L.W., Urak, R.Z., Chang, W.C., Khaled, S.K., Siddiqi, T., Budde, L.E., Xu, J., Chang, B., Gidwaney, N., Thomas, S.H., Cooper, L.J.N., Riddell, S.R., Brown, C.E., Jensen, M.C., and Forman, S.J. (2016). Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL. Blood 127, 2980–2990.
Wang, Z., Guo, Y., and Han, W. (2017). Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment. Protein Cell in press doi: 10.1007/s13238-017-0400-z.
Zhang, T., Cao, L., Xie, J., Shi, N., Zhang, Z., Luo, Z., Yue, D., Zhang, Z., Wang, L., Han, W., Xu, Z., Chen, H., and Zhang, Y. (2015). Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysis. Oncotarget 6, 33961–33971.
Acknowledgements
This work was supported by the Science and Technology Planning Project of Beijing City (Z151100003915076 to Weidong Han), the National Key Research and Development Program of China (2016YFC1303501, 2016YFC1303504 to Weidong Han) and the National Natural Science Foundation of China (81502679 to Can Luo).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wei, J., Han, W. CART trials are going ahead. Sci. China Life Sci. 60, 1276–1279 (2017). https://doi.org/10.1007/s11427-017-9198-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-017-9198-1