Science China Life Sciences

, Volume 60, Issue 4, pp 345–347 | Cite as

Profile of Yi-Han Chen

Profile From CAS Members


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Selected publications

  1. Chen, Y.H., Xu, S., Bendahhou, S., Wang, X., Wang, Y., Xu, W., Jin, H., Sun, H., Su, X., Zhuang, Q., Yang, Y., Li, Y., Liu, Y., Xu, H., Li, X., Ma, N., Mou, C., Chen, Z., Barhanin, J., and Huang, W. (2003). KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299, 251–254.CrossRefPubMedGoogle Scholar
  2. Li, J., Li, C., Liang, D., Lv, F., Yuan, T., The, E., Ma, X., Wu, Y., Zhen, L., Xie, D., Wang, S., Liu, Y., Huang, J., Shi, J., Liu, Y., Shi, D., Xu, L., Lin, L., Peng, L., Cui, J., Zhu, W., and Chen, Y.H. (2016). LRP6 acts as a scaffold protein in cardiac gap junction assembly. Nat Commun 7, 11775.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Li, J., Li, C., Zhang, D., Shi, D., Qi, M., Feng, J., Yuan, T., Xu, X., Liang, D., Xu, L., Zhang, H., Liu, Y., Chen, J., Ye, J., Jiang, W., Cui, Y., Zhang, Y., Peng, L., Zhou, Z., and Chen, Y.H. (2014). SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain. Nat Commun 5, 5177.CrossRefPubMedGoogle Scholar
  4. Li, J., Qi, M., Li, C., Shi, D., Zhang, D., Xie, D., Yuan, T., Feng, J., Liu, Y., Liang, D., Xu, X., Chen, J., Xu, L., Zhang, H., Ye, J., Lv, F., Huang, J., Peng, L., and Chen, Y.H. (2014). Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Cell Res 24, 977–993.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Li, J., Xiao, J., Liang, D., Zhang, H., Zhang, G., Liu, Y., Zhang, Y., Liu, Y., Yu, Z., Yan, B., Jiang, B., Li, F., Peng, L., Zhou, Z., and Chen, Y.H. (2010). Inhibition of mitochondrial translocator protein prevents atrial fibrillation. Eur J Pharmacol 632, 60–64.CrossRefPubMedGoogle Scholar
  6. Li, J., Xie, D., Huang, J., Lv, F., Shi, D., Liu, Y., Lin, L., Geng, L., Wu, Y., Liang, D., and Chen, Y.H. (2015). Cold-inducible RNA-binding protein regulates cardiac repolarization by targeting transient outward potassium channels. Circ Res 116, 1655–1659.CrossRefPubMedGoogle Scholar
  7. Li, J., Xiao, J., Liu, Y., Zhang, G., Zhang, H., Liang, D., Liu, Y., Zhang, Y., Hu, Y., Yu, Z., Yan, B., Jiang, B., Peng, L., Zhou, Z., and Chen, Y.H. (2009). Mitochondrial benzodiazepine receptors mediate cardioprotection of estrogen against ischemic ventricular fibrillation. Pharmacol Res 60, 61–67.CrossRefPubMedGoogle Scholar
  8. Li, J., Zhang, D., Ye, J., Li, C., Qi, M., Liang, D., Xu, X., Xu, L., Liu, Y., Zhang, H., Zhang, Y., Deng, F., Feng, J., Shi, D., Chen, J., Li, L., Chen, G., Sun, Y., Peng, L., and Chen, Y.H. (2013). Dynamin-2 mediates heart failure by modulating Ca2+-dependent cardiomyocyte apoptosis. Int J Cardiol 168, 2109–2119.CrossRefPubMedGoogle Scholar
  9. Liang, X., Wang, G., Lin, L., Lowe, J., Zhang, Q., Bu, L., Chen, Y., Chen, J., Sun, Y., and Evans, S.M. (2013). HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res 113, 399–407.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Liang, X., Zhang, Q., Cattaneo, P., Zhuang, S., Gong, X., Spann, N.J., Jiang, C., Cao, X., Zhao, X., Zhang, X., Bu, L., Wang, G., Chen, H., Zhuang, T., Yan, J., Geng, P., Luo, L., Banerjee, I., Chen, Y., Glass, C.K., Zambon, A.C., Chen, J., Sun, Y., and Evans, S.M. (2015). Transcription factor ISL1 is essential for pacemaker development and function. J Clin Invest 125, 3256–3268.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Wo, D., Peng, J., Ren, D., Qiu, L., Chen, J., Zhu, Y., Yan, Y., Yan, H., Wu, J., Ma, E., Zhong, T., Chen, Y., Liu, Z., Liu, S., Ao, L., Liu, Z., Jiang, C., Peng, J., Zou, Y., Qian, Q., and Zhu, W. (2016). Opposing roles of wnt inhibitors IGFBP-4 and Dkk1 in cardiac ischemia by differential targeting of LRP5/6 and β-catenin. Circulation 134, 1991–2007.CrossRefPubMedGoogle Scholar
  12. Xiao, J., Liang, D., and Chen, Y.H. (2011). The genetics of atrial fibrillation: from the bench to the bedside. Annu Rev Genomics Hum Genet 12, 73–96.CrossRefPubMedGoogle Scholar
  13. Xu, L., Pan, L., Li, J., Huang, B., Feng, J., Li, C., Wang, S., The, E., Liu, Y., Yuan, T., Zhen, L., Liang, D., Liu, Y., Li, L., Cui, Y., Jiang, X., Peng, L., and Chen, Y.H. (2015). Nucleoporin 35 regulates cardiomyocyte pH homeostasis by controlling Na+-H+ exchanger-1 expression. J Mol Cell Biol 7, 476–485.CrossRefPubMedGoogle Scholar
  14. Yu, Z., Wang, L., Wang, C., Ju, X., Wang, M., Chen, K., Loro, E., Li, Z., Zhang, Y., Wu, K., Casimiro, M.C., Gormley, M., Ertel, A., Fortina, P., Chen, Y.H., Tozeren, A., Liu, Z., and Pestell, R.G. (2013). Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat Commun 4, 2812.PubMedPubMedCentralGoogle Scholar
  15. Zhou, T., Li, J., Zhao, P., Liu, H., Jia, D., Jia, H., He, L., Cang, Y., Boast, S., Chen, Y.H., Thibault, H., Scherrer-Crosbie, M., Goff, S.P., and Li, B. (2015). Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci USA 112, 15666–15671.PubMedPubMedCentralGoogle Scholar

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