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Science China Life Sciences

, Volume 59, Issue 4, pp 436–437 | Cite as

Functional spermatid-like cells derived from the ground-state embryonic stem cells in vitro

  • Yan Zhang
  • Yixun Liu
Open Access
Research Highlight

Keywords

Germ Cell Methylation Level Testicular Cell Haploid Cell Cell Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Daley, G.Q., (2007). Gametes from embryonic stem cells: a cup half empty or half full Science 316, 409–410.CrossRefPubMedGoogle Scholar
  2. Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S., and Saitou M. (2011). Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell 146, 519–532.CrossRefPubMedGoogle Scholar
  3. Hunter, D., Anand-Ivell, R., Danner, S., and Ivell, R. (2012). Models of in vitro spermatogenesis. Spermatogenesis 2, 32–43.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Shen, L., Inoue, A., He, J., Liu, Y., Lu, F., and Zhang, Y. (2014). Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes. Cell Stem Cell 15, 459–470.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Ying, Q.L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., and Smith, A. (2008). The ground state of embryonic stem cell self-renewal. Nature 453, 519–523.CrossRefPubMedGoogle Scholar
  6. Zhou, Q., Wang, M., Yuan, Y., Wang, X., Fu, R., Wan, H., Xie, M., Liu, M., Guo, X., Zheng, Y., Feng, G., Shi, Q., Zhao, X.Y., Sha, J., and Zhou, Q. (2016). Complete meiosis from embryonic stem cell-derived germ cells in vitro. Cell Stem Cell 18, 330–340CrossRefPubMedGoogle Scholar

Copyright information

© The Author(s) 2016

Authors and Affiliations

  1. 1.State Key Laboratory of Stem Cell and Reproductive Biology, Institute of ZoologyChinese Academy of SciencesBeijingChina

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