This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price includes VAT (USA)
Tax calculation will be finalised during checkout.
Band, P.R., Maroun, J., Pritchard, K., Stewart, D., Coppin, C.M., Wilson, K., and Eisenhauer, E.A. (1986). Phase II study of lonidamine in patients with metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group Study. Cancer Treat Rep 70, 1305–1310.
Chao, M., Wu, H., Jin, K., Li, B., Wu, J., Zhang, G., Yang, G., and Hu, X. (2016). A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis. eLife 5, e15691.
DeAngelo, A.B., Daniel, F.B., Stober, J.A., and Olson, G.R. (1991). The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse. Fundam Appl Toxicol 16, 337–347.
Dorff, T.B., Groshen, S., Garcia, A., Shah, M., Tsao-Wei, D., Pham, H., Cheng, C.W., Brandhorst, S., Cohen, P., Wei, M., Longo, V., and Quinn, D.I. (2016). Safety and feasibility of fasting in combination with platinum- based chemotherapy. BMC Cancer 16, 360.
Ganapathy-Kanniappan, S., and Geschwind, J.F.H. (2013). Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer 12, 152.
He, Q., Lu, W.S., Liu, Y., Guan, Y.S., and Kuang, A.R. (2013). 131I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma. World J Gastroenterol 19, 9104–9110.
Marchiq, I., and Pouysségur, J. (2016). Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters. J Mol Med 94, 155–171.
Qorraj, M., Bruns, H., Böttcher, M., Weigand, L., Saul, D., Mackensen, A., Jitschin, R., and Mougiakakos, D. (2016). The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia. Leukemia in press doi: 10.1038/leu.2016.214.
Schwartz, K., Chang, H.T., Nikolai, M., Pernicone, J., Rhee, S., Olson, K., Kurniali, P.C., Hord, N.G., and Noel, M. (2015). Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature. Cancer Metab 3, 3.
Wu, H., Ding, Z., Hu, D., Sun, F., Dai, C., Xie, J., and Hu, X. (2012). Central role of lactic acidosis in cancer cell resistance to glucose deprivationinduced cell death. J Pathol 227, 189–199.
This work was supported by the Breast Cancer Research Foundation and the National Institutes of Health to Mark I. Greene (R01CA089481, R01CA149425), and the Department of Defense Lung Cancer Research Program Idea Development Award grant to Sunil Singhal (W81XWH-15-1-0362). Mr. Cameron Jeffers kindly read the manuscript and provided discussions and suggestions.
About this article
Cite this article
Zhang, H. Will cancer cells be defeated by sodium bicarbonate?. Sci. China Life Sci. 60, 326–328 (2017). https://doi.org/10.1007/s11427-016-0373-3