References
Calin, G.A., Dumitru, C.D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., Rassenti, L., Kipps, T., Negrini, M., Bullrich, F., and Croce, C.M. (2002). Nonlinear partial differential equations and applications: frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99, 15524–15529.
Croce, C.M. (2009). Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 10, 704–714.
Lu, J., Getz, G., Miska, E.A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B.L., Mak, R.H., Ferrando, A.A., Downing, J.R., Jacks, T., Horvitz, H.R., and Golub, T.R. (2005). MicroRNA expression profiles classify human cancers. Nature 435, 834–838.
Melo, S.A., Moutinho, C., Ropero, S., Calin, G.A., Rossi, S., Spizzo, R., Fernandez, A.F., Davalos, V., Villanueva, A., Montoya, G., Yamamoto, H., Schwartz, S., and Esteller, M. (2010). A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 18, 303–315.
Peng, Y., and Croce, C.M. (2016). The role of microRNAs in human cancer. Sig Transduct Target Ther 1, 15004.
Sun, H.L., Cui, R., Zhou, J.K., Teng, K.Y., Hsiao, Y.H., Nakanishi, K., Fassan, M., Luo, Z., Shi, G., Tili, E., Kutay, H., Lovat, F., Vicentini, C., Huang, H.L., Wang, S.W., Kim, T., Zanesi, N., Jeon, Y.J., Lee, T.J., Guh, J.H., Hung, M.C., Ghoshal, K., Teng, C.M., Peng, Y., and Croce, C.M. (2016). ERK activation globally downregulates miRNAs through phosphorylating exportin-5. Cancer Cell 30, 723–736.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wei, YQ. Impaired XPO5 function leads to transportation failure of microRNA precursor. Sci. China Life Sci. 60, 677–679 (2017). https://doi.org/10.1007/s11427-016-0365-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-016-0365-3