Abstract
This study aimed to evaluate if macular autofluorescence (MAF) is a valuable, non-invasive follow-up parameter for cystoid macular edema. A total of 71 eyes (71 cases) with cystoid macular edema (CME) were included in the study. Macular pigment (MP) was evaluated using HRA2 (infrared) IF and FA models. The density of MP was graded into three categories: without, partial, and normal amount of MP. A comparison was made between the baseline (before the first administration) level and at the fourth month, following three consecutive intravitreal lucentis injections every month. The morphology and distribution of MAF, and the density and distribution of MP were regarded as the main outcome measures. At the baseline visit, all eyes with CME had petaloid/irregular-shaped MAF in the macular area (100%). No MAF was detected in the control eyes (0). There was significant difference in MAF between the CME and normal groups (P=0.000). At the fourth monthly visit, normal levels of MP density without MAF was detected in 68 eyes (95.8%) with the best corrected spectacular visual acuity increasing to at least 1 line accordingly. We conclude that macular MAF can be used as a follow-up parameter for patients with CME. MP and MAF can indirectly reflect the fovea cone function.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Antcliff RJ, Stanford MR, Chauhan DS, Chauhan DS, Graham EM, Spalton DJ, Shilling JS, Ffytche TJ. Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis. Ophthalmology, 2000, 107: 593–599
Zhang X, Gillies M, Zhu X, Wang X, Xiao Y, Xu X. The correlation study of mauclar autofluorescence and macular pigment in cystoid macular edema. Ophthalmol CHN, 2010, 19: 357–360
Aizawa S, Mitamura Y, Hagiwara A, Sugawara T, Yamamoto S. Changes of fundus autofluorescence, photoreceptor inner and outer segment junction line, and visual function in patients with retinitis pigmentosa. Clin Experiment Ophthalmol, 2010, 38: 597–604
Bearelly S, Cousins SW. Fundus autofluorescence imaging in age-related macular degeneration and geographic atrophy. Adv Exp Med Biol, 2010, 664: 395–402
Jarc-Vidmar M, Kraut A, Hawlina M. Fundus autofluorescence imaging in Best's vitelliform dystrophy. Klin Monbl Augenheilkd, 2003, 220: 861–867
Zhang X, Hargitai J, Tammur J, Amy H, Rando A, Stanley C, Gouras P. Macular pigment and visual acuity in Stargardt macular dystrophy. Graefes Arch Clin Exp Ophthalmol, 2002, 240: 802–809
Zhang X, Zeng H, Bao S, Wang N, Gillies M. Diabetic macular edema: new concepts in patho-physiology and treatment. Cell Biosci, 2014, 4: 27
Rapp LM, Maple SS, Choi JH. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Invest Ophthalmol Vis Sci, 2000, 41: 1200–1209
Snodderly DM, Brown PK, Delori FC, Auran JD. The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas. Invest Ophthalmol Vis Sci, 1984, 25: 660–673
Snodderly DM, Auran JD, Delori FC. The macular pigment. II. Spatial distribution in primate retinas. Invest Ophthalmol Vis Sci, 1984, 25: 674–685
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is published with open access at link.springer.com
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Zhang, X., Gong, X., Wang, Y. et al. Macular auto-fluorescence is a follow-up parameter for cystoids macular edema. Sci. China Life Sci. 58, 773–777 (2015). https://doi.org/10.1007/s11427-015-4905-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-015-4905-5