Skip to main content

May early intervention with intravenous immunoglobulin pose a potentially successful treatment for Ebola virus infection?

References

  1. Towner JS, Sealy TK, Khristova ML, Albariño CG, Conlan S, Reeder SA, Quan PL, Lipkin WI, Downing R, Tappero JW, Okware S, Lutwama J, Bakamutumaho B, Kayiwa J, Comer JA, Rollin PE, Ksiazek TG, Nichol ST. Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS Pathog, 2008, 4: e100212

    Article  Google Scholar 

  2. Smith LM, Hensley LE, Geisbert TW, Johnson J, Stossel A, Honko A, Yen JY, Geisbert J, Paragas J, Fritz E, Olinger G, Young HA, Rubins KH, Karp CL. Interferon-ß therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. J Infect Dis, 2013, 208: 310–318

    PubMed  CAS  PubMed Central  Article  Google Scholar 

  3. Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ. Development of a preventive vaccine for Ebola virus infection in primates. Nature, 2000, 408: 605–609

    PubMed  CAS  Article  Google Scholar 

  4. Elshabrawy HA, Fan J, Haddad CS, Ratia K, Broder CC, Caffrey M, Prabhakar BS. Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay. J Virol, 2014, 88: 4353e65

    Article  Google Scholar 

  5. Mahanty S, Bray M. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect Dis, 2004, 4: 487–498

    PubMed  CAS  Article  Google Scholar 

  6. Xie J, Jiao Y, Qiu ZF, Li Q, Li TS. Significant elevation of B cells at acute stage in enterovirus 71-infected children with central nervous system involvement. Scand J Infect Dis, 2010, 42: 931–935

    PubMed  CAS  Article  Google Scholar 

  7. Mori I, Parizot C, Dorgham K, Demeret S, Amoura Z, Bolgert F, Gorochov G. Prominent plasmacytosis following intravenous immunoglobulin correlates with clinical improvement in Guillain-barre syndrome. PLoS One, 2008, 3: e2109–2118

    PubMed  PubMed Central  Article  Google Scholar 

  8. Sundblad A, Marcos MA, Malanchere E, Castro A, Haury M, Huetz F, Nobrega A, Freitas A, Coutinho A. Observations on the mode of action of normal immunoglobulin at high doses. Immunol Rev, 1994, 139: 125–158

    PubMed  CAS  Article  Google Scholar 

  9. Makhoul B, Braun E, Herskovitz M, Ramadan R, Hadad S, Norberto K. Hyperimmune gammaglobulin for the treatment of West Nile virus encephalitis. Isr Med Assoc J, 2009, 11: 151–153

    PubMed  Google Scholar 

  10. Shen X, Tomaras GD. Alterations of the B-cell response by HIV-1 replication. Curr HIV/aids Rep, 2011, 8: 23–30

    PubMed  CAS  PubMed Central  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to TaiSheng Li.

Additional information

This article is published with open access at link.springer.com

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ge, Y., Li, T. May early intervention with intravenous immunoglobulin pose a potentially successful treatment for Ebola virus infection?. Sci. China Life Sci. 58, 108–110 (2015). https://doi.org/10.1007/s11427-014-4794-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11427-014-4794-z

Keywords

  • Severe Acute Respiratory Syndrome
  • Capillary Leak Syndrome
  • Central Nervous System Complication
  • Severe Acute Respiratory Syndrome Coronavirus
  • Convalescent Plasma