Article PDF
Avoid common mistakes on your manuscript.
References
Adham, M., Kurniawan, A.N,, Muhtadi, A.I., Roezin, A., Hermani, B., Gondhowiardjo, S., Tan, I.B., and Middeldorp, J.M. (2012). Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer 31, 185–196.
Bei, J.X., Li, Y., Jia, W.H., Feng, B.J., Zhou, G., Chen, L.Z., Feng, Q.S., Low, H.Q., Zhang, H., He, F., Tai, E.S., Kang, T., Liu, E.T., Liu, J., and Zeng, Y.X. (2010). A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet 42, 599–603.
Cao, S.M., Simons, M.J., and Qian, C.N. (2011). The prevalence and prevention of nasopharyngeal carcinoma in China. Chin J Cancer 30, 114–119.
Cao, Y., Zhang, Z.L., Zhou, M., Elson, P., Rini, B., Aydin, H., Feenstra, K., Tan, M.H., Berghuis, B., Tabbey, R., Resau, J.H., Zhou, F.J., Teh, B.T., and Qian, C.N. (2013). Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma. Cancer 119, 313–324.
Chen, Y.F., and Fu, L.W. (2011a). Mechanisms of acquired resistance to tyrosine kinase inhibitors. Acta Pharm Sin B 1, 197–207.
Chen, Z., and Zhou, G. (2011b). Translational medicine should translate medical science and technology into health care for everyone in China. Sci China Life Sci 54, 1074–1076.
Dai, C.L., Liang, Y.J., Chen, L.M., Zhang, X., Deng, W.J., Su, X.D., Shi, Z., Wu, C.P., Ashby, C.R. Jr., Akiyama, S., Ambudkar, S.V., Chen, Z.S., and Fu, L.W. (2008a). Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function. Biochem Pharmacol 78, 355–364.
Dai, C.L., Tiwari, A.K., Wu, C.P., Su, X.D., Wang, S.R., Liu, D.G., Ashby, C.R. Jr., Huang, Y., Robey, R.W., Liang, Y.J., Chen, L.M., Shi, C.J., Ambudkar, S.V., Chen, Z.S., and Fu, L.W. (2008b). Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res 68, 7905–7914.
Dardari, R., Hinderer, W., Lang, D., Benider, A., EI Gueddari, B., Joab, I., Benslimane, A., and Khyatti, M. (2001). Antibody responses to recombinant Epstein-Barr virus antigens in nasopharyngeal carcinoma patients: complementary test of ZEBRA protein and early antigens p54 and p138. J Clin Microbiol 39, 3164–3170.
Deng, R., Tang, J., Xia, L.P., Li, D.D., Zhou, W.J., Wang, L.L., Feng, G.K., Zeng, Y.X., Gao, Y.H., and Zhu, X.F. (2009). ExcisaninA induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. Mol Cancer Ther 8, 873–882.
Deng, R., Tang, J., Xie, B.F., Feng, G.K., Huang, Y.H., Liu, Z.C., and Zhu, X.F. (2010). SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway. Int J Cancer 127, 220–229.
Deng, R., Yang, F., Chang, S.H., Tang, J., Qin, J., Feng, G.K., Ding, K., and Zhu, X.F. (2012). DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth. Mol Pharmacol 82, 189–198.
Feng, B.J., Huang, W., Shugart, Y.Y., Lee, M.K., Zhang, F., Xia, J.C., Wang, H.Y., Huang, T.B., Jian, S.W., Huang, P., Feng, Q.S., Huang, L.X., Yu, X.J., Li, D., Chen, L.Z., Jia, W.H., Fang, Y., Huang, H.M., Zhu, J.L., Liu, X.M., Zhao, Y., Liu, W.Q., Deng, M.Q., Hu, W.H., Wu, S.X., Mo, H.Y., Hong, M.F., King, M.C., Chen, Z., and Zeng, Y.X. (2002). Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet 31, 395–399.
Gautschi, O., Heighway, J., Mack, P.C., Purnell, P.R., Lara, P.N. Jr., and Gandara, D.R. (2008). Aurora kinases as anticancer drug targets. Clin Cancer Res 14, 1639–1648.
Guan, Z., Wang, X.R., Zhu, X.F., Huang, X.F., Xu, J., Wang, L.H., Wan, X.B., Long, Z.J., Liu, J.N., Feng, G.K., Huang, W., Zeng, Y.X., Chen, F.J., and Liu, Q. (2007). Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res 67, 10436–10444.
Huang, B.J., Liu, R.Y., Huang, J.L., Liang, Z.H., Gao, G.F., Wu, J.X., and Huang, W. (2007). Long-term toxicity studies in Canine of E10A, an adenoviral vector for human endostatin gene. Hum Gene Ther 18, 207–221.
Kataki, A.C., Simons, M.J., Das, A.K., Sharma, K., and Mehra, N.K. (2011). Nasopharyngeal carcinoma in the Northeastern states of India. Chin J Cancer 30, 106–113.
Li, H.L., Li, S., Shao, J.Y., Lin, X.B., Cao, Y., Jiang, W.Q., Liu, R.Y., Zhao, P., Zhu, X.F., Zeng, M.S., Guan, Z.Z., and Huang, W. (2008). Pharmacokinetic and pharmacodynamic study of intratumoral injection of an adenovirus encoding endostatin in patients with advanced tumors. Gene Ther 15, 247–256.
Li, G.P., Wang, H., Lai, Y.K., Chen, S.C., Lin, M.C., Lu, G., Zhang, J.F., He, X.G., Qian, C.N., and Kung, H.F. (2011a). Proteomic profiling between CNE-2 and its strongly metastatic subclone S-18 and functional characterization of HSP27 in metastasis of nasopharyngeal carcinoma. Proteomics 11, 2911–2920.
Li, X.J., Ong, C.K., Cao, Y., Xiang, Y.Q., Shao, J.Y., Ooi, A., Peng, L.X., Lu, W.H., Zhang, Z., Petillo, D., Qin, L., Bao, Y.N., Zheng, F.J., Chia, C.S., Iyer, N.G., Kang, T.B., Zeng, Y.X., Soo, K.C., Trent, J.M., The, B.T., and Qian, C.N. (2011b). Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Res 71, 3162–3172.
Li, X.J., Peng, L.X., Shao, J.Y., Lu, W.H., Zhang, J.X., Chen, S., Chen, Z.Y., Xiang, Y.Q., Bao, Y.N., Zheng, F.J., Zeng, M.S., Kang, T.B., Zeng, Y.X., Teh, B.T., and Qian, C.N. (2012). As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. Carcinogenesis 33, 1302–1309.
Lin, X., Huang, H., Li, S., Li, H., Li, Y., Cao, Y., Zhang, D., Xia, Y., Guo, Y., Huang, W., and Jiang, W. (2007). A phase I clinical trial of an adenovirus- mediated endostatin gene (E10A) in patients with solid tumors. Cancer Biol Ther 6, 648–653.
Liu, N., Chen, N.Y., Cui, R.X., Li, W.F., Li, Y., Wei, R.R., Zhang, M.Y., Sun, Y., Huang, B.J., Chen, M., He, Q.M., Jiang, N., Chen, L., Cho, W.C., Yun, J.P., Zeng, J., Liu, L.Z., Li, L., Guo, Y., Wang, H.Y., and Ma, J. (2012). Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol 13, 633–641.
Liu, Q., Zhang, X., and Zeng, Y. (2011). Targeted and personalized therapy for cancer: theory and practice in China. Sci China Life Sci 54, 1081–1084.
Lu, J.J., Cooper, J.S., and Lee, A.W.M. (2010). Nasopharyngeal Cancer: Multidisciplinary Management (Berlin & Heidelberg: Springer-Verlag).
Mi, Y.J., Liang, Y.J., Huang, H.B., Zhao, H.Y., Wu, C.P., Wang, F., Tao, L.Y., Zhang, C.Z., Dai, C.L., Tiwari, A.K., Ma, X.X., To, K.K., Ambudkar, S.V., Chen, Z.S., and Fu, L.W. (2010). Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res 70, 7981–7991.
Qian, C.N. (2010). Exploration of the postponing mechanism that delays carcinoma onset. Cancer Cell Int 10, 38.
Qian, C.N., Berghuis, B., Tsarfaty, G., Bruch, M., Kort, E.J., Ditlev, J., Tsarfaty, I., Hudson, E., Jackson, D.G., Petillo, D., Chen, J., Resau, J.H., and Teh, B.T. (2006). Preparing the “soil”: the primary tumor in duces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells. Cancer Res 66, 10365–10376.
Qian, C.N., Huang, D., Wondergem, B., and Teh, B.T. (2009). Complexity of tumor vasculature in clear cell renal cell carcinoma. Cancer 115, 2282–2289.
Qian, C.N., Resau, J.H., and Teh, B.T. (2007). Prospects for vasculature reorganization in sentinel lymph nodes. Cell Cycle 6, 514–517.
Qin, H.D., Shugart, Y.Y., Bei, J.X., Pan, Q.H., Chen, L., Feng, Q.S., Chen, L.Z., Huang, W., Liu, J.J., Jorgensen, T.J., Zeng, Y.X., and Jia, W.H. (2011). Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinoma. Cancer Res 71, 3000–3008.
Qin, L., Bromberg-White, J.L., and Qian, C.N. (2012). Opportunities and challenges in tumor angiogenesis research: back and forth between bench and bed. Adv Cancer Res 113, 191–239.
Shugart, Y.Y., Wang, Y., Jia, W.H., and Zeng, Y. (2011). GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases. Chin J Cancer 30, 226–230.
Simons, M.J. (2011). Nasopharyngeal carcinoma as a paradigm of cancer genetics. Chin J Cancer 30, 79–84.
Wan, X.B., Long, Z.J., Yan, M., Xu, J., Xia, L.P., Liu, L., Zhao, Y., Huang, X.F., Wang, X.R., Zhu, X.F., Hong, M.H., and Liu, Q. (2008). Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. Carcinogenesis 29, 1930–1937.
Wang, H.Y., Sun, B.Y., Zhu, Z.H., Chang, E.T., To, K.F., Hwang, J.S., Jiang, H., Kam, M.K., Chen, G., Cheah, S.L., Lee, M., Liu, Z.W., Chen, J., Zhang, J.X., Zhang, H.Z., He, J.H., Chen, F.L., Zhu, X.D., Huang, M.Y., Liao, D.Z., Fu, J., Shao, Q., Cai, M.B., Du, Z.M., Yan, L.X., Hu, C.F., Ng, H.K., Wee, J.T., Qian, C.N., Liu, Q., Ernberg, I., Ye, W., Adami, H.O., Chan, A.T., Zeng, Y.X., and Shao, J.Y. (2011). Eight-signature classifier for prediction of nasopharyngeal carcinoma survival. J Clin Oncol 29, 4516–4525.
Wang, L.H., Xiang, J., Yan, M., Zhang, Y., Zhao, Y., Yue, C.F., Xu, J., Zheng, F.M., Chen, J.N., Kang, Z., Chen, T.S., Xing, D., and Liu, Q. (2010). Mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by up-regulating cofilin activity. Cancer Res 70, 9118–9128.
Watson, R.W., Kay, E.W., and Smith, D. (2010). Integrating biobanks: addressing the practical and ethical issues to deliver a valuable tool for cancer research. Nat Rev Cancer 10, 646–651.
Xu, J., Wan, X.B., Huang, X.F., Chan, K.C., Hong, M.H., Wang, L.H., Long, Z.J., Liu, Q., Yan, M., Lo, Y.M., Zeng, Y.X., and Liu, Q. (2010). Serologic antienzyme rate of Epstein-Barr virus DNase-specific neutralizing antibody segregates TNM classification in nasopharyngeal carcinoma. J Clin Oncology 28, 5202–5209.
Yan, Y.Y., Zheng, L.S., Zhang, X., Chen, L.K., Singh, S., Wang, F., Zhang, J.Y., Liang, Y.J., Dai, C.L., Gu, L.Q., Zeng, M.S., Talele, T.T., Chen, Z.S., and Fu, L.W. (2011). Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu. Mol Pharm 8, 1687–1697.
Yao, X., Qian, C.N., Zhang, Z.F., Tan, M.H., Kort, E.J., Yang, X.J., Resau, J.H., and Teh, B.T. (2007). Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications. Clin Cancer Res 13, 161–169.
Zhou, J.M., Zhu, X.F., Lu, Y.J., Deng, R., Huang, Z.S., Mei, Y.P., Wang, Y., Huang, W.L., Liu, Z.C., Gu, L.Q., and Zeng, Y.X. (2006). Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene 25, 503–511.
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is published with open access at link.springer.com
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Guerin, M., Qian, C., Zhong, Q. et al. Translational oncology toward benefiting cancer patients: the Sun Yat-sen University Cancer Center experience. Sci. China Life Sci. 59, 1057–1062 (2016). https://doi.org/10.1007/s11427-012-4398-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-012-4398-4