Science China Life Sciences

, Volume 55, Issue 8, pp 670–676 | Cite as

Epigenetic changes associated with oocyte aging

  • XingWei Liang
  • JunYu Ma
  • Heide Schatten
  • QingYuan Sun
Open Access
Review Special Topic

Abstract

It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process. Here, we review the epigenetic alterations, mainly focused on DNA methylation, histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age. Furthermore, we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging.

Keywords

fertility advanced maternal age postovulatory oocyte aging DNA methylation histone modification 

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Copyright information

© The Author(s) 2012

Authors and Affiliations

  • XingWei Liang
    • 1
    • 2
  • JunYu Ma
    • 1
  • Heide Schatten
    • 3
  • QingYuan Sun
    • 1
  1. 1.State Key Laboratory of Reproductive Biology, Institute of ZoologyChinese Academy of SciencesBeijingChina
  2. 2.Department of Animal SciencesChungbuk National UniversityCheongjuRepublic of Korea
  3. 3.Department of Veterinary PathobiologyUniversity of MissouriColumbiaUSA

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