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Ca2+ signalling in cardiovascular disease: the role of the plasma membrane calcium pumps
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  • Published: 24 July 2011

Ca2+ signalling in cardiovascular disease: the role of the plasma membrane calcium pumps

  • Elizabeth J. Cartwright1,
  • Delvac Oceandy1,
  • Clare Austin1 &
  • …
  • Ludwig Neyses1 

Science China Life Sciences volume 54, pages 691–698 (2011)Cite this article

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Abstract

The plasma membrane calcium ATPases (PMCA) are a family of genes which extrude Ca2+ from the cell and are involved in the maintenance of intracellular free calcium levels and/or with Ca2+ signalling, depending on the cell type. In the cardiovascular system, Ca2+ is not only essential for contraction and relaxation but also has a vital role as a second messenger in signal transduction pathways. A complex array of mechanisms regulate intracellular free calcium levels in the heart and vasculature and a failure in these systems to maintain normal Ca2+ homeostasis has been linked to both heart failure and hypertension. This article focuses on the functions of PMCA, in particular isoform 4 (PMCA4), in the heart and vasculature and the reported links between PMCAs and contractile function, cardiac hypertrophy, cardiac rhythm and sudden cardiac death, and blood pressure control and hypertension. It is becoming clear that this family of calcium extrusion pumps have essential roles in both cardiovascular health and disease.

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Authors and Affiliations

  1. Cardiovascular Medicine Research Group, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK

    Elizabeth J. Cartwright, Delvac Oceandy, Clare Austin & Ludwig Neyses

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  1. Elizabeth J. Cartwright
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  2. Delvac Oceandy
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  3. Clare Austin
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Correspondence to Elizabeth J. Cartwright.

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Cartwright, E.J., Oceandy, D., Austin, C. et al. Ca2+ signalling in cardiovascular disease: the role of the plasma membrane calcium pumps. Sci. China Life Sci. 54, 691–698 (2011). https://doi.org/10.1007/s11427-011-4199-1

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  • Received: 17 May 2011

  • Accepted: 10 June 2011

  • Published: 24 July 2011

  • Issue Date: August 2011

  • DOI: https://doi.org/10.1007/s11427-011-4199-1

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Keywords

  • plasma membrane calcium/calmodulin-dependent ATPase
  • Ca2+ homeostasis
  • Ca2+ signalling
  • heart failure
  • hypertension
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