Abstract
The study of ion channels represents one of the most active fields in neuroscience research in China. In the last 10 years, active research in various Chinese neuroscience institutions has sought to understand the mechanisms responsible for sensory processing, neural development and neurogenesis, neural plasticity, as well as pathogenesis. In addition, extensive studies have been directed to measure ion channel activity, structure-function relationships, as well as many other biophysical and biochemical properties. This review focuses on the progress achieved in the investigation of ion channels in neuronal survival during the past 10 years in China.
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Dolmetsch R E, Pajvani U, Fife K, et al. Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science, 2001, 294: 333–339, 10.1126/science.1063395, 1:CAS:528:DC%2BD3MXnsFGqsL4%3D, 11598293
Lipton P. Ischemic cell death in brain neurons. Physiol Rev, 1999, 79: 1431–1568, 1:STN:280:DyaK1MvjvVagtw%3D%3D, 10508238
Gruol D L, Barker J L, Huang L Y, et al. Hydrogen ions have multiple effects on the excitability of cultured mammalian neurons. Brain Res, 1980, 183: 247–252, 10.1016/0006-8993(80)90138-9, 1:CAS:528:DyaL3cXhtVGjtL8%3D, 7357408
Krishtal O A, Pidoplichko V I. A receptor for protons in the membrane of sensory neurons may participate in nociception. Neuroscience, 1981, 6: 2599–2601, 10.1016/0306-4522(81)90105-6, 1:STN:280:DyaL387gsVehtg%3D%3D, 6275299
Varming T. Proton-gated ion channels in cultured mouse cortical neurons. Neuropharmacology, 1999, 38: 1875–1881, 10.1016/S0028-3908(99)00079-9, 1:CAS:528:DyaK1MXotVOqs7k%3D, 10608282
Alvarez de la Rosa D, Canessa C M, Fyfe G K, et al. Structure and regulation of amiloride-sensitive sodium channels. Annu Rev Physiol, 2000, 62: 573–594, 10.1146/annurev.physiol.62.1.573, 1:STN:280:DC%2BD3cvktFKgtg%3D%3D, 10845103
Waldmann R, Champigny G, Bassilana F, et al. A proton-gated cation channel involved in acid-sensing. Nature, 1997, 386: 173–177, 10.1038/386173a0, 1:CAS:528:DyaK2sXhvFSqtrY%3D, 9062189
Krishtal O. The ASICs: Signaling molecules? Modulators? Trends Neurosci, 2003, 26: 477–483, 10.1016/S0166-2236(03)00210-8, 1:CAS:528:DC%2BD3sXms1yhu74%3D, 12948658
Wu L J, Duan B, Mei Y D, et al. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem, 2004, 279: 43716–43724, 10.1074/jbc.M403557200, 1:CAS:528:DC%2BD2cXot1ygsro%3D, 15302881
Yermolaieva O, Leonard A S, Schnizler M K, et al. Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a. Proc Natl Acad Sci USA, 2004, 101: 6752–6757, 10.1073/pnas.0308636100, 1:CAS:528:DC%2BD2cXjvVyhs7s%3D, 15082829
Bianchi L, Driscoll M. Protons at the gate: DEG/ENaC ion channels help us feel and remember. Neuron, 2002, 34: 337–340, 10.1016/S0896-6273(02)00687-6, 1:CAS:528:DC%2BD38XjsFGgurY%3D, 11988165
Wemmie J A, Chen J, Askwith C C, et al. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron, 2002, 34: 463–477, 10.1016/S0896-6273(02)00661-X, 1:CAS:528:DC%2BD38XjsFGgu7c%3D, 11988176
Siesjo B K, Katsura K, Kristian T. Acidosis-related damage. Adv Neurol, 1996, 71: 209–233; discussion 234–206, 1:STN:280:DyaK28zot12gtQ%3D%3D, 8790801
Jasti J, Furukawa H, Gonzales E B, et al. Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature, 2007, 449: 316–323, 10.1038/nature06163, 1:CAS:528:DC%2BD2sXhtVKiu7vE, 17882215
Simon R P, Swan J H, Griffiths T, et al. Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science, 1984, 226: 850–852, 10.1126/science.6093256, 1:CAS:528:DyaL2MXjsl0%3D, 6093256
Sattler R, Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol, 2001, 24: 107–129, 10.1385/MN:24:1-3:107, 1:CAS:528:DC%2BD38XnsVaqug%3D%3D, 11831548
Xiong Z G, Zhu X M, Chu X P, et al. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell, 2004, 118: 687–698, 10.1016/j.cell.2004.08.026, 1:CAS:528:DC%2BD2cXnvFehtb4%3D, 15369669
Gao J, Duan B, Wang D G, et al. Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron, 2005, 48: 635–646, 10.1016/j.neuron.2005.10.011, 1:CAS:528:DC%2BD2MXhtlSms7nJ, 16301179
Pignataro G, Simon R P, Xiong Z G. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain, 2007, 130: 151–158, 10.1093/brain/awl325, 17114797
Besancon E, Guo S, Lok J, et al. Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends Pharmacol Sci, 2008, 29: 268–275, 10.1016/j.tips.2008.02.003, 1:CAS:528:DC%2BD1cXlslWqu7k%3D, 18384889
Isaev N K, Stelmashook E V, Plotnikov E Y, et al. Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia. Biochemistry (Mosc), 2008, 73: 1171–1175, 10.1134/S0006297908110011, 1:CAS:528:DC%2BD1cXhsVegu7vO
Chittajallu R, Braithwaite S P, Clarke V R, et al. Kainate receptors: Subunits, synaptic localization and function. Trends Pharmacol Sci, 1999, 20: 26–35, 10.1016/S0165-6147(98)01286-3, 1:CAS:528:DyaK1MXks1amsb0%3D, 10101959
Chung H J, Xia J, Scannevin R H, et al. Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. J Neurosci, 2000, 20: 7258–7267, 1:CAS:528:DC%2BD3cXnt1ajsb0%3D, 11007883
Tian H, Zhang Q G, Zhu G X, et al. Activation of c-Jun NH2-terminal kinase 3 is mediated by the GluR6.PSD-95.MLK3 signaling module following cerebral ischemia in rat hippocampus. Brain Res, 2005, 1061: 57–66, 1:CAS:528:DC%2BD2MXhtFOgs77O, 16256962
Pei D S, Sun Y F, Guan Q H, et al. Postsynaptic density protein 95 antisense oligodeoxynucleotides inhibits the activation of MLK3 and JNK3 via the GluR6. PSD-95.MLK3 signaling module after transient cerebral ischemia in rat hippocampus. Neurosci Lett, 2004, 367: 71–75, 10.1016/j.neulet.2004.05.082, 1:CAS:528:DC%2BD2cXmsleksr0%3D, 15308300
Pei D S, Wang X T, Liu Y, et al. Neuroprotection against ischaemic brain injury by a GluR6–9c peptide containing the TAT protein transduction sequence. Brain, 2006, 129: 465–479, 10.1093/brain/awh700, 16330502
Pei D S, Guan Q H, Sun Y F, et al. Neuroprotective effects of GluR6 antisense oligodeoxynucleotides on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 region. J Neurosci Res, 2005, 82: 642–649, 10.1002/jnr.20669, 1:CAS:528:DC%2BD2MXhtlekt7rK, 16267825
Chen J, Li C, Pei D S, et al. GluR6-containing KA receptor mediates the activation of p38 MAP kinase in rat hippocampal CA1 region during brain ischemia injury. Hippocampus, 2009, 19: 79–89, 10.1002/hipo.20479, 1:CAS:528:DC%2BD1MXitl2qurs%3D, 18680160
Gu Z, Jiang Q, Zhang G. c-Jun N-terminal kinase activation in hippocampal CA1 region was involved in ischemic injury. Neuroreport, 2001, 12: 897–900, 10.1097/00001756-200104170-00006, 1:CAS:528:DC%2BD3MXjtVWhu74%3D, 11303755
Tian H, Zhang G, Li H, et al. Antioxidant NAC and AMPA/KA receptor antagonist DNQX inhibited JNK3 activation following global ischemia in rat hippocampus. Neurosci Res, 2003, 46: 191–197, 1:CAS:528:DC%2BD3sXktFWlt7g%3D, 12767482
Xu J, Liu Y, Zhang G Y. Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase. J Biol Chem, 2008, 283: 29355–29366, 10.1074/jbc.M800393200, 1:CAS:528:DC%2BD1cXht1GlsbrL, 18678878
Choi D W. Calcium: Still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci, 1995, 18: 58–60, 10.1016/0166-2236(95)93870-4, 1:CAS:528:DyaK2MXjtlGiurw%3D, 7537408
Li X M, Yang J M, Hu D H, et al. Contribution of downregulation of L-type calcium currents to delayed neuronal death in rat hippocampus after global cerebral ischemia and reperfusion. J Neurosci, 2007, 27: 5249–5259, 10.1523/JNEUROSCI.0802-07.2007, 1:CAS:528:DC%2BD2sXmtVWrtrc%3D, 17494711
Jia Y, Zhou J, Tai Y, et al. TRPC channels promote cerebellar granule neuron survival. Nat Neurosci, 2007, 10: 559–567, 10.1038/nn1870, 1:CAS:528:DC%2BD2sXksFShs7Y%3D, 17396124
Minke B. Drosophila mutant with a transducer defect. Biophys Struct Mech, 1977, 3: 59–64, 10.1007/BF00536455, 1:STN:280:DyaE2s7lvVCgsw%3D%3D, 870103
Montell C, Jones K, Hafen E, et al. Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science, 1985, 230: 1040–1043, 10.1126/science.3933112, 1:CAS:528:DyaL28XivFOitA%3D%3D, 3933112
Montell C, Birnbaumer L, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell, 2002, 9: 229–231, 10.1016/S1097-2765(02)00448-3, 1:CAS:528:DC%2BD38XhvFKhurc%3D, 11864597
Segal R A, Greenberg M E. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci, 1996, 19: 463–489, 1:CAS:528:DyaK28XhsVCksrY%3D, 8833451
Clapham D E. TRP channels as cellular sensors. Nature, 2003, 426: 517–524, 10.1038/nature02196, 1:CAS:528:DC%2BD3sXpsVejtrc%3D, 14654832
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Wang, Y., Xu, T. Ion channels in neuronal survival. Sci. China Life Sci. 53, 342–347 (2010). https://doi.org/10.1007/s11427-010-0060-1
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DOI: https://doi.org/10.1007/s11427-010-0060-1