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microRNA-181b targets MLK2 in HL-60 cells

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Abstract

microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.

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Authors and Affiliations

  1. The First Affiliated Hospital of Harbin Medical University, Harbin, 150101, China

    Hong Chen & Yan Mi

  2. Harbin Acheng District People’s Hospital, Harbin, 150300, China

    Qun Chen

  3. Graduate department of Harbin Medical University, Harbin, 150001, China

    Ming Fang

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  1. Hong Chen
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  2. Qun Chen
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  3. Ming Fang
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  4. Yan Mi
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Correspondence to Yan Mi.

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Chen, H., Chen, Q., Fang, M. et al. microRNA-181b targets MLK2 in HL-60 cells. Sci. China Life Sci. 53, 101–106 (2010). https://doi.org/10.1007/s11427-010-0002-y

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