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Towards transgenic primates: What can we learn from mouse genetics?

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Abstract

Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.

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Authors and Affiliations

  1. Brain and Behavior Discovery Institute, School of Medicine, Medical College of Georgia, Augusta, GA, 30912, USA

    Hui Kuang, Phillip L. Wang & Joe Z. Tsien

  2. Yunnan Banna Primate Disease Model Research Center, and Shanghai Institute of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, MOE & STCSM, East China Normal University, Shanghai, 200062, China

    Hui Kuang, Phillip L. Wang & Joe Z. Tsien

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  1. Hui Kuang
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Kuang, H., Wang, P.L. & Tsien, J.Z. Towards transgenic primates: What can we learn from mouse genetics?. SCI CHINA SER C 52, 506–514 (2009). https://doi.org/10.1007/s11427-009-0082-8

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