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Immunomodulatory effects of Caulerpa racemosa var peltata polysaccharide and its selenizing product on T lymphocytes and NK cells in mice

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Abstract

A polysaccharide, CrvpPS, was isolated from Caulerpa racemosa var peltata. It was reacted with nano-selenium in distilled water containing ascorbic acid (Vit C) to form a stable CrvpPS-nano-Se complex. The immunomodulatory effects of CrvpPS and CrvpPS-nano-Se on T lymphocytes subgroups and NK cells in mice were investigated. After intragastric administration for 10 days separately, both CrvpPS and CrvpPS-nano-Se showed significant stimulatory functions to thymus gland of mice. Moreover, the CrvpPS-nano-Se induced the percentage of CD3+, CD3+CD4+, NK cells and the CD4+/CD8+ value to increase significantly (P<0.05) when analyzed by flow cytometry, which is better than the CrvpPS, sucrose-nano-Se, and even the positive drug levamisole.

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Authors and Affiliations

  1. Department of Anatomy, Medical College, Jinan University, Guangzhou, 510630, China

    WeiZai Shen, Hui Wang, GuoQing Guo & JingJing Tuo

  2. Ultrasonic Division, Municipal Hospital of Weihai, Shandong, 264200, China

    JingJing Tuo

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  1. WeiZai Shen
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  2. Hui Wang
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  3. GuoQing Guo
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  4. JingJing Tuo
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Correspondence to WeiZai Shen.

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Supported by the Team Project of Guangdong Natural Science Foundation (Grant No. 039213)

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Shen, W., Wang, H., Guo, G. et al. Immunomodulatory effects of Caulerpa racemosa var peltata polysaccharide and its selenizing product on T lymphocytes and NK cells in mice. SCI CHINA SER C 51, 795–801 (2008). https://doi.org/10.1007/s11427-008-0106-9

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  • DOI: https://doi.org/10.1007/s11427-008-0106-9

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