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Association of β-fibrinogen gene −148C/T and −455G/A polymorphisms and coronary artery disease in Chinese population: A Meta analysis

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Abstract

The purpose of our study was to evaluate the correlation between the β-fibrinogen gene −148C/T and −455G/A polymorphisms and susceptibility to coronary artery disease in the Chinese population using a meta-analytic approach. Eligible studies about this correlation were identified by searching the PubMed, EMBASE, and CNKI databases. Of the 13 identified, 7 (with 1488 cases and 1234 controls) involved the −148C/T polymorphism and 9 (with 1023 cases and 1081 controls) involved the −455G/A polymorphism. No publication bias was detectable and heterogeneity testing found significant differences between the ORs for both groups of studies. The combined OR for the 7 studies on susceptibility to coronary artery disease in −148T allele carriers compared to the −148C/C wild-type homozygotes was 1.31 (95%CI: 0.94–1.84, P=0.11). The combined OR for the 9 studies on susceptibility to coronary artery disease in −455A allele carriers compared to the −455G/G wild-type homozygotes was 1.75 (95%CI: 1.24–2.46, P=0.001). Our results suggest the absence of an association between the β-fibrinogen gene −148C/T polymorphism and susceptibility to coronary artery disease and the possibility that −455G/A polymorphism (in particular, allele A) increases susceptibility to this disease in the Chinese population.

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Authors and Affiliations

  1. Department of Cardiology, Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China

    XiaoChao Chen, LiZi Jin & Jian Chen

  2. Department of Endocrinology, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510120, China

    MingTong Xu

  3. Department of Epidemiology, Public Health College, Sun Yat-sen University, Guangzhou, 510080, China

    WeiQing Chen

Authors
  1. XiaoChao Chen
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  2. MingTong Xu
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  3. LiZi Jin
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  4. Jian Chen
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  5. WeiQing Chen
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Correspondence to MingTong Xu.

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Contributed equally to this work

Supported by Guangdong Science Technology Project Foundation (Grant No. 2005B3370321, 2006B36007005) and Zhuhai Municipal Science Technology Foundation (Grant No. PB20051015)

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Chen, X., Xu, M., Jin, L. et al. Association of β-fibrinogen gene −148C/T and −455G/A polymorphisms and coronary artery disease in Chinese population: A Meta analysis. SCI CHINA SER C 51, 814–820 (2008). https://doi.org/10.1007/s11427-008-0102-0

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